ID   OR4A5_HUMAN             Reviewed;         315 AA.
AC   Q8NH83; Q6IF84;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 4.
DT   13-SEP-2023, entry version 158.
DE   RecName: Full=Olfactory receptor 4A5;
DE   AltName: Full=Olfactory receptor OR11-111;
GN   Name=OR4A5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4A5";
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DR   EMBL; AB065506; BAC05754.1; -; Genomic_DNA.
DR   EMBL; AC087377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004378; DAA04776.1; -; Genomic_DNA.
DR   CCDS; CCDS73289.1; -.
DR   RefSeq; NP_001005272.3; NM_001005272.3.
DR   AlphaFoldDB; Q8NH83; -.
DR   SMR; Q8NH83; -.
DR   STRING; 9606.ENSP00000367664; -.
DR   GlyCosmos; Q8NH83; 1 site, No reported glycans.
DR   GlyGen; Q8NH83; 1 site.
DR   iPTMnet; Q8NH83; -.
DR   PhosphoSitePlus; Q8NH83; -.
DR   BioMuta; OR4A5; -.
DR   DMDM; 327478606; -.
DR   MassIVE; Q8NH83; -.
DR   PaxDb; Q8NH83; -.
DR   PeptideAtlas; Q8NH83; -.
DR   ProteomicsDB; 73683; -.
DR   Antibodypedia; 27099; 20 antibodies from 10 providers.
DR   DNASU; 81318; -.
DR   Ensembl; ENST00000319760.8; ENSP00000367664.2; ENSG00000221840.4.
DR   GeneID; 81318; -.
DR   KEGG; hsa:81318; -.
DR   MANE-Select; ENST00000319760.8; ENSP00000367664.2; NM_001005272.3; NP_001005272.3.
DR   UCSC; uc001nhi.3; human.
DR   AGR; HGNC:15162; -.
DR   CTD; 81318; -.
DR   DisGeNET; 81318; -.
DR   GeneCards; OR4A5; -.
DR   HGNC; HGNC:15162; OR4A5.
DR   HPA; ENSG00000221840; Not detected.
DR   neXtProt; NX_Q8NH83; -.
DR   OpenTargets; ENSG00000221840; -.
DR   VEuPathDB; HostDB:ENSG00000221840; -.
DR   eggNOG; ENOG502SJPV; Eukaryota.
DR   GeneTree; ENSGT00940000155775; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NH83; -.
DR   OMA; WCKNLTK; -.
DR   OrthoDB; 4655770at2759; -.
DR   PhylomeDB; Q8NH83; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q8NH83; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 81318; 15 hits in 680 CRISPR screens.
DR   GeneWiki; OR4A5; -.
DR   GenomeRNAi; 81318; -.
DR   Pharos; Q8NH83; Tdark.
DR   PRO; PR:Q8NH83; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH83; Protein.
DR   ExpressionAtlas; Q8NH83; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15939; 7tmA_OR4A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF161; OLFACTORY RECEPTOR 4A5-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 4A5"
FT                   /id="PRO_0000150524"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..232
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..286
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        287..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..186
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         6
FT                   /note="N -> S (in dbSNP:rs10902343)"
FT                   /id="VAR_031741"
FT   VARIANT         23
FT                   /note="K -> N (in dbSNP:rs56302591)"
FT                   /id="VAR_062033"
FT   VARIANT         219
FT                   /note="L -> Q (in dbSNP:rs35083184)"
FT                   /id="VAR_062034"
FT   CONFLICT        16
FT                   /note="S -> F (in Ref. 1; BAC05754)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        48..49
FT                   /note="IA -> FS (in Ref. 1; BAC05754)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        54..56
FT                   /note="GSP -> CSA (in Ref. 1; BAC05754)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   315 AA;  34915 MW;  E0659F90F54E9921 CRC64;
     MRQNNNITEF VLLGFSQDPG VQKALFVMFL LTYLVTVVGN LLIVVDIIAS PSLGSPMYFF
     LACLSFIDAA YSTTISPKLI VGLFCDKKTI SFQGCMGQLF IDHFFGGAEV FLLVVMACDR
     YVAICKPLHY LTIMNRQVCF LLLVVAMIGG FVHSAFQIVV YSLPFCGPNV IVHFSCDMHP
     LLELACTDTY FIGLTVVVNS GAICMVIFNL LLISYGVILS SLKTYSQEKR GKALSTCSSG
     STVVVLFFVP CIFIYVRPVS NFPTDKFMTV FYTIITHMLS PLIYTLRNSE MRNAIEKLLG
     KKLTIFIIGG VSVLM
//