ID   O10AG_HUMAN             Reviewed;         301 AA.
AC   Q8NH19; B2RNH4; Q6IEU3;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   22-FEB-2023, entry version 157.
DE   RecName: Full=Olfactory receptor 10AG1;
DE   AltName: Full=Olfactory receptor OR11-160;
GN   Name=OR10AG1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q8NH19; P41181: AQP2; NbExp=3; IntAct=EBI-13339917, EBI-12701138;
CC       Q8NH19; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-13339917, EBI-6942903;
CC       Q8NH19; O00559: EBAG9; NbExp=3; IntAct=EBI-13339917, EBI-8787095;
CC       Q8NH19; O15552: FFAR2; NbExp=3; IntAct=EBI-13339917, EBI-2833872;
CC       Q8NH19; P15941-11: MUC1; NbExp=3; IntAct=EBI-13339917, EBI-17263240;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10AG1";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065594; BAC05822.1; -; Genomic_DNA.
DR   EMBL; CH471076; EAW73692.1; -; Genomic_DNA.
DR   EMBL; BC136890; AAI36891.1; -; mRNA.
DR   EMBL; BC136891; AAI36892.1; -; mRNA.
DR   EMBL; BK004519; DAA04917.1; -; Genomic_DNA.
DR   RefSeq; NP_001005491.1; NM_001005491.1.
DR   AlphaFoldDB; Q8NH19; -.
DR   SMR; Q8NH19; -.
DR   BioGRID; 129411; 5.
DR   IntAct; Q8NH19; 5.
DR   STRING; 9606.ENSP00000311477; -.
DR   GlyCosmos; Q8NH19; 1 site, No reported glycans.
DR   GlyGen; Q8NH19; 1 site.
DR   iPTMnet; Q8NH19; -.
DR   PhosphoSitePlus; Q8NH19; -.
DR   BioMuta; OR10AG1; -.
DR   DMDM; 38503050; -.
DR   PaxDb; Q8NH19; -.
DR   PeptideAtlas; Q8NH19; -.
DR   Antibodypedia; 58952; 101 antibodies from 22 providers.
DR   DNASU; 282770; -.
DR   Ensembl; ENST00000312345.4; ENSP00000311477.2; ENSG00000174970.5.
DR   GeneID; 282770; -.
DR   KEGG; hsa:282770; -.
DR   UCSC; uc010rit.2; human.
DR   AGR; HGNC:19607; -.
DR   CTD; 282770; -.
DR   GeneCards; OR10AG1; -.
DR   HGNC; HGNC:19607; OR10AG1.
DR   HPA; ENSG00000174970; Not detected.
DR   neXtProt; NX_Q8NH19; -.
DR   PharmGKB; PA134929321; -.
DR   VEuPathDB; HostDB:ENSG00000174970; -.
DR   eggNOG; ENOG502SI62; Eukaryota.
DR   GeneTree; ENSGT01050000244815; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NH19; -.
DR   OrthoDB; 5309234at2759; -.
DR   PhylomeDB; Q8NH19; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; Q8NH19; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NH19; -.
DR   BioGRID-ORCS; 282770; 7 hits in 749 CRISPR screens.
DR   GeneWiki; OR10AG1; -.
DR   GenomeRNAi; 282770; -.
DR   Pharos; Q8NH19; Tdark.
DR   PRO; PR:Q8NH19; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH19; protein.
DR   ExpressionAtlas; Q8NH19; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF159; OLFACTORY RECEPTOR 10AG1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..301
FT                   /note="Olfactory receptor 10AG1"
FT                   /id="PRO_0000150692"
FT   TOPO_DOM        1..16
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..37
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..45
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..90
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        112..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        152..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..208
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..228
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..301
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        82
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        88..180
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   301 AA;  34105 MW;  BDDC23BD2F3D6822 CRC64;
     MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM YFFLSNFSLL
     EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG TECLLLTVMA YDRYVAICKP
     LQYPLVMNHK VCIQLIIASW TITIPVVIGE TCQIFLLPFC GTNTINHFFC DIPPILKLAC
     GNIFVNEITV HVVAVVFITV PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI
     LFFGAGTITY LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL
     T
//