ID   OR2L2_HUMAN             Reviewed;         312 AA.
AC   Q8NH16; Q2M3T5;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   02-DEC-2020, entry version 150.
DE   RecName: Full=Olfactory receptor 2L2;
DE   AltName: Full=HTPCRH07;
DE   AltName: Full=Olfactory receptor 2L12;
DE   AltName: Full=Olfactory receptor 2L4;
GN   Name=OR2L2; Synonyms=OR2L12, OR2L4P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 125-238.
RC   TISSUE=Testis;
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2L2";
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DR   EMBL; AB065597; BAC05825.1; -; Genomic_DNA.
DR   EMBL; BC104792; AAI04793.1; -; mRNA.
DR   EMBL; BC104794; AAI04795.1; -; mRNA.
DR   EMBL; X64978; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS31103.1; -.
DR   RefSeq; NP_001004686.1; NM_001004686.2.
DR   RefSeq; XP_011542460.1; XM_011544158.2.
DR   STRING; 9606.ENSP00000355435; -.
DR   GlyGen; Q8NH16; 2 sites.
DR   iPTMnet; Q8NH16; -.
DR   PhosphoSitePlus; Q8NH16; -.
DR   BioMuta; OR2L2; -.
DR   DMDM; 38258181; -.
DR   PaxDb; Q8NH16; -.
DR   PRIDE; Q8NH16; -.
DR   ProteomicsDB; 73647; -.
DR   Antibodypedia; 54364; 21 antibodies.
DR   Ensembl; ENST00000366479; ENSP00000355435; ENSG00000203663.
DR   Ensembl; ENST00000641771; ENSP00000493410; ENSG00000203663.
DR   Ensembl; ENST00000642011; ENSP00000493154; ENSG00000203663.
DR   GeneID; 26246; -.
DR   KEGG; hsa:26246; -.
DR   UCSC; uc001idw.4; human.
DR   CTD; 26246; -.
DR   EuPathDB; HostDB:ENSG00000203663.3; -.
DR   GeneCards; OR2L2; -.
DR   HGNC; HGNC:8266; OR2L2.
DR   HPA; ENSG00000203663; Tissue enhanced (brain, testis).
DR   neXtProt; NX_Q8NH16; -.
DR   OpenTargets; ENSG00000203663; -.
DR   PharmGKB; PA32183; -.
DR   eggNOG; ENOG502RTYI; Eukaryota.
DR   GeneTree; ENSGT00970000193401; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NH16; -.
DR   OMA; SWMISSI; -.
DR   OrthoDB; 950954at2759; -.
DR   PhylomeDB; Q8NH16; -.
DR   TreeFam; TF337295; -.
DR   PathwayCommons; Q8NH16; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 26246; 1 hit in 455 CRISPR screens.
DR   GeneWiki; OR2L2; -.
DR   GenomeRNAi; 26246; -.
DR   Pharos; Q8NH16; Tdark.
DR   PRO; PR:Q8NH16; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NH16; protein.
DR   Bgee; ENSG00000203663; Expressed in C1 segment of cervical spinal cord and 30 other tissues.
DR   ExpressionAtlas; Q8NH16; baseline and differential.
DR   Genevisible; Q8NH16; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Polymorphism; Receptor; Reference proteome;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 2L2"
FT                   /id="PRO_0000150486"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..157
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         249
FT                   /note="F -> L (in dbSNP:rs12134979)"
FT                   /id="VAR_053144"
FT   VARIANT         259
FT                   /note="V -> L (in dbSNP:rs6658141)"
FT                   /id="VAR_053145"
SQ   SEQUENCE   312 AA;  35495 MW;  C85F0368D685C1DE CRC64;
     MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL DIHLHTPMYF
     LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS FFFLTLAVAE GLLLTSMAYD
     RYVAICFPLH YPIRISKRVC VMMITGSWMI SSINSCAHTV YALCIPYCKS RAINHFFCDV
     PAMLTLACTD TWVYESTVFL SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC
     STHLTVVSFY YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL
     TQVIQKIFSV KM
//