ID   OR1J2_HUMAN             Reviewed;         313 AA.
AC   Q8NGS2; A3KFL9; Q6IF14; Q96R90; Q9NZP1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   13-SEP-2023, entry version 160.
DE   RecName: Full=Olfactory receptor 1J2;
DE   AltName: Full=HSA5;
DE   AltName: Full=HTPCRX15;
DE   AltName: Full=OST044;
DE   AltName: Full=Olfactory receptor 1J3;
DE   AltName: Full=Olfactory receptor 1J5;
DE   AltName: Full=Olfactory receptor OR9-19;
GN   Name=OR1J2; Synonyms=OR1J3, OR1J5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-285.
RX   PubMed=10706615; DOI=10.1073/pnas.040580197;
RA   Rouquier S., Blancher A., Giorgi D.;
RT   "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT   reduction of the functional fraction in primates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
RC   TISSUE=Testis;
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [8]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1J2";
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DR   EMBL; AB065717; BAC05938.1; -; Genomic_DNA.
DR   EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471090; EAW87531.1; -; Genomic_DNA.
DR   EMBL; AF399552; AAK95037.1; -; Genomic_DNA.
DR   EMBL; AF179767; AAF40352.1; -; Genomic_DNA.
DR   EMBL; X64989; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004448; DAA04846.1; -; Genomic_DNA.
DR   CCDS; CCDS35121.1; -.
DR   RefSeq; NP_473448.1; NM_054107.1.
DR   RefSeq; XP_016870112.1; XM_017014623.1.
DR   AlphaFoldDB; Q8NGS2; -.
DR   SMR; Q8NGS2; -.
DR   STRING; 9606.ENSP00000335575; -.
DR   GlyCosmos; Q8NGS2; 1 site, No reported glycans.
DR   GlyGen; Q8NGS2; 1 site.
DR   BioMuta; OR1J2; -.
DR   DMDM; 38372761; -.
DR   MassIVE; Q8NGS2; -.
DR   PaxDb; Q8NGS2; -.
DR   PeptideAtlas; Q8NGS2; -.
DR   Antibodypedia; 66861; 27 antibodies from 11 providers.
DR   DNASU; 26740; -.
DR   Ensembl; ENST00000335302.5; ENSP00000335575.5; ENSG00000197233.7.
DR   GeneID; 26740; -.
DR   KEGG; hsa:26740; -.
DR   MANE-Select; ENST00000335302.5; ENSP00000335575.5; NM_054107.1; NP_473448.1.
DR   UCSC; uc011lyv.2; human.
DR   AGR; HGNC:8209; -.
DR   CTD; 26740; -.
DR   DisGeNET; 26740; -.
DR   GeneCards; OR1J2; -.
DR   HGNC; HGNC:8209; OR1J2.
DR   HPA; ENSG00000197233; Not detected.
DR   neXtProt; NX_Q8NGS2; -.
DR   OpenTargets; ENSG00000197233; -.
DR   PharmGKB; PA32080; -.
DR   VEuPathDB; HostDB:ENSG00000197233; -.
DR   eggNOG; ENOG502T8AD; Eukaryota.
DR   GeneTree; ENSGT00940000163995; -.
DR   HOGENOM; CLU_012526_1_3_1; -.
DR   InParanoid; Q8NGS2; -.
DR   OMA; ANTIPHV; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGS2; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NGS2; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26740; 11 hits in 737 CRISPR screens.
DR   ChiTaRS; OR1J2; human.
DR   GeneWiki; OR1J2; -.
DR   GenomeRNAi; 26740; -.
DR   Pharos; Q8NGS2; Tdark.
DR   PRO; PR:Q8NGS2; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGS2; Protein.
DR   Bgee; ENSG00000197233; Expressed in buccal mucosa cell and 6 other tissues.
DR   ExpressionAtlas; Q8NGS2; baseline and differential.
DR   Genevisible; Q8NGS2; HS.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15918; 7tmA_OR1_7-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF9; OLFACTORY RECEPTOR 1J2; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Olfactory receptor 1J2"
FT                   /id="PRO_0000150439"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         119
FT                   /note="A -> T (in dbSNP:rs41277120)"
FT                   /id="VAR_062010"
FT   VARIANT         165
FT                   /note="R -> Q (in dbSNP:rs4836891)"
FT                   /id="VAR_053123"
FT   CONFLICT        148
FT                   /note="S -> T (in Ref. 5; AAF40352)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   313 AA;  35385 MW;  8408D57426DA3001 CRC64;
     MSPENQSSVS EFLLLGLPIR PEQQAVFFTL FLGMYLTTVL GNLLIMLLIQ LDSHLHTPMY
     FFLSHLALTD ISFSSVTVPK MLMDMRTKYK SILYEECISQ MYFFIFFTDL DSFLITSMAY
     DRYVAICHPL HYTVIMREEL CVFLVAVSWI LSCASSLSHT LLLTRLSFCA ANTIPHVFCD
     LAALLKLSCS DIFLNELVMF TVGVVVITLP FMCILVSYGY IGATILRVPS TKGIHKALST
     CGSHLSVVSL YYGSIFGQYL FPTVSSSIDK DVIVALMYTV VTPMLNPFIY SLRNRDMKEA
     LGKLFSRATF FSW
//