ID   OR1B1_HUMAN             Reviewed;         317 AA.
AC   Q8NGR6; Q6IFN3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2024, sequence version 3.
DT   24-JUL-2024, entry version 158.
DE   RecName: Full=Olfactory receptor 1B1;
DE   AltName: Full=Olfactory receptor 9-B;
DE            Short=OR9-B;
DE   AltName: Full=Olfactory receptor OR9-26;
GN   Name=OR1B1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN   [5]
RP   POLYMORPHISM.
RX   PubMed=12730696; DOI=10.1038/ng1160;
RA   Menashe I., Man O., Lancet D., Gilad Y.;
RT   "Different noses for different people.";
RL   Nat. Genet. 34:143-144(2003).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- POLYMORPHISM: A stop codon at position Arg-192 in the gene coding for
CC       this protein is responsible for functional diversity thus producing a
CC       pseudogene. The stop codon is more frequent in non-Africans than in
CC       African-Americans.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA04627.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1B1";
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DR   EMBL; AB065723; BAC05944.1; -; Genomic_DNA.
DR   EMBL; AL162254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004229; DAA04627.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_001004450.1; NM_001004450.1.
DR   RefSeq; XP_016870184.1; XM_017014695.1.
DR   RefSeq; XP_016870185.1; XM_017014696.1.
DR   AlphaFoldDB; Q8NGR6; -.
DR   SMR; Q8NGR6; -.
DR   STRING; 9606.ENSP00000485577; -.
DR   GlyCosmos; Q8NGR6; 2 sites, No reported glycans.
DR   GlyGen; Q8NGR6; 2 sites.
DR   PhosphoSitePlus; Q8NGR6; -.
DR   BioMuta; OR1B1; -.
DR   DMDM; 166214963; -.
DR   jPOST; Q8NGR6; -.
DR   MassIVE; Q8NGR6; -.
DR   PaxDb; 9606-ENSP00000303151; -.
DR   PeptideAtlas; Q8NGR6; -.
DR   Antibodypedia; 78801; 52 antibodies from 16 providers.
DR   DNASU; 347169; -.
DR   Ensembl; ENST00000623530.2; ENSP00000485577.2; ENSG00000280094.3.
DR   Ensembl; ENST00000707075.1; ENSP00000516726.1; ENSG00000280094.3.
DR   GeneID; 347169; -.
DR   KEGG; hsa:347169; -.
DR   MANE-Select; ENST00000623530.2; ENSP00000485577.2; NM_001004450.3; NP_001004450.2.
DR   UCSC; uc011lyz.2; human.
DR   AGR; HGNC:8181; -.
DR   CTD; 347169; -.
DR   DisGeNET; 347169; -.
DR   GeneCards; OR1B1; -.
DR   HGNC; HGNC:8181; OR1B1.
DR   HPA; ENSG00000280094; Not detected.
DR   neXtProt; NX_Q8NGR6; -.
DR   PharmGKB; PA32055; -.
DR   VEuPathDB; HostDB:ENSG00000280094; -.
DR   eggNOG; ENOG502QWKX; Eukaryota.
DR   GeneTree; ENSGT00900000141254; -.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q8NGR6; -.
DR   OMA; VSVVHTM; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGR6; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NGR6; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 347169; 9 hits in 738 CRISPR screens.
DR   GeneWiki; OR1B1; -.
DR   GenomeRNAi; 347169; -.
DR   Pharos; Q8NGR6; Tdark.
DR   PRO; PR:Q8NGR6; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGR6; Protein.
DR   Bgee; ENSG00000280094; Expressed in cortical plate and 8 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15235; 7tmA_OR1A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF125; OLFACTORY RECEPTOR 1B1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..317
FT                   /note="Olfactory receptor 1B1"
FT                   /id="PRO_0000150416"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..66
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..201
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..184
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         148
FT                   /note="L -> S (in dbSNP:rs1536929)"
FT                   /id="VAR_053114"
FT   VARIANT         229
FT                   /note="A -> T (in dbSNP:rs1476859)"
FT                   /id="VAR_053115"
FT   VARIANT         262
FT                   /note="C -> W (in dbSNP:rs1476858)"
FT                   /id="VAR_053116"
FT   VARIANT         313
FT                   /note="V -> G (in dbSNP:rs1556189)"
FT                   /id="VAR_053117"
SQ   SEQUENCE   317 AA;  35162 MW;  14C05679BBBB6242 CRC64;
     MSFAPNASHS PVFLLLGFSR ANISYTLLFF LFLAIYLTTI LGNVTLVLLI SWDSRLHSPM
     YYLLRGLSVI DMGLSTVTLP QLLAHLVSHY PTIPAARCLA QFFFFYAFGV TDTLVIAVMA
     LDRYVAICDP LHYALVMNHQ RCACLLALSW VVSILHTMLR VGLVLPLCWT GDAGGNVNLP
     HFFCDHRPLL RASCSDIHSN ELAIFFEGGF LMLGPCALIV LSYVRIGAAI LRLPSAAGRR
     RAVSTCGSHL TMVGFLYGTI ICVYFQPPFQ NSQYQDMVAS VMYTAITPLA NPFVYSLHNK
     DVKGALCRLL EWVKVDP
//