ID   OR5C1_HUMAN             Reviewed;         320 AA.
AC   Q8NGR4; B2RN54; B9EGT0; Q96RC4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   22-FEB-2023, entry version 153.
DE   RecName: Full=Olfactory receptor 5C1;
DE   AltName: Full=Olfactory receptor 5C2;
DE   AltName: Full=Olfactory receptor 9-F;
DE            Short=OR9-F;
GN   Name=OR5C1; Synonyms=OR5C2P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 72-288.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5C1";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065725; BAC05946.1; -; Genomic_DNA.
DR   EMBL; BC136700; AAI36701.1; -; mRNA.
DR   EMBL; BC136701; AAI36702.1; -; mRNA.
DR   EMBL; AF399514; AAK94999.1; -; Genomic_DNA.
DR   CCDS; CCDS35131.1; -.
DR   RefSeq; NP_001001923.1; NM_001001923.1.
DR   AlphaFoldDB; Q8NGR4; -.
DR   SMR; Q8NGR4; -.
DR   BioGRID; 134202; 7.
DR   STRING; 9606.ENSP00000362784; -.
DR   GlyCosmos; Q8NGR4; 1 site, No reported glycans.
DR   GlyGen; Q8NGR4; 1 site.
DR   iPTMnet; Q8NGR4; -.
DR   PhosphoSitePlus; Q8NGR4; -.
DR   BioMuta; OR5C1; -.
DR   DMDM; 38372754; -.
DR   MassIVE; Q8NGR4; -.
DR   PaxDb; Q8NGR4; -.
DR   Antibodypedia; 72100; 13 antibodies from 8 providers.
DR   DNASU; 392391; -.
DR   Ensembl; ENST00000373680.3; ENSP00000362784.2; ENSG00000148215.4.
DR   GeneID; 392391; -.
DR   KEGG; hsa:392391; -.
DR   MANE-Select; ENST00000373680.3; ENSP00000362784.2; NM_001001923.1; NP_001001923.1.
DR   UCSC; uc011lzd.2; human.
DR   AGR; HGNC:8331; -.
DR   CTD; 392391; -.
DR   GeneCards; OR5C1; -.
DR   HGNC; HGNC:8331; OR5C1.
DR   HPA; ENSG00000148215; Not detected.
DR   neXtProt; NX_Q8NGR4; -.
DR   PharmGKB; PA32511; -.
DR   VEuPathDB; HostDB:ENSG00000148215; -.
DR   eggNOG; ENOG502RF3K; Eukaryota.
DR   GeneTree; ENSGT01040000240414; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGR4; -.
DR   OMA; FVHTTLT; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGR4; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q8NGR4; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 392391; 14 hits in 750 CRISPR screens.
DR   GeneWiki; OR5C1; -.
DR   GenomeRNAi; 392391; -.
DR   Pharos; Q8NGR4; Tdark.
DR   PRO; PR:Q8NGR4; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGR4; protein.
DR   Bgee; ENSG00000148215; Expressed in sural nerve.
DR   ExpressionAtlas; Q8NGR4; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15945; 7tmA_OR5C1-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF105; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..320
FT                   /note="Olfactory receptor 5C1"
FT                   /id="PRO_0000150590"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..200
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..241
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..320
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        101..193
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   320 AA;  34991 MW;  BFEFBCE40A988BD5 CRC64;
     MNSENLTRAA VAPAEFVLLG ITNRWDLRVA LFLTCLPVYL VSLLGNMGMA LLIRMDARLH
     TPMYFFLANL SLLDACYSSA IGPKMLVDLL LPRATIPYTA CALQMFVFAG LADTECCLLA
     AMAYDRYVAI RNPLLYTTAM SQRLCLALLG ASGLGGAVSA FVHTTLTFRL SFCRSRKINS
     FFCDIPPLLA ISCSDTSLNE LLLFAICGFI QTATVLAITV SYGFIAGAVI HMRSVEGSRR
     AASTGGSHLT AVAMMYGTLI FMYLRPSSSY ALDTDKMASV FYTLVIPSLN PLIYSLRNKE
     VKEALRQTWS RFHCPGQGSQ
//