ID   OR1L6_HUMAN             Reviewed;         347 AA.
AC   Q8NGR2; Q6IFM8; Q96R80;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   08-NOV-2023, entry version 156.
DE   RecName: Full=Olfactory receptor 1L6;
DE   AltName: Full=Olfactory receptor 1L7;
DE   AltName: Full=Olfactory receptor OR9-30;
GN   Name=OR1L6; Synonyms=OR1L7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-319.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-37 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05948.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1L6";
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DR   EMBL; AB065727; BAC05948.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AC006313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399563; AAK95048.1; -; Genomic_DNA.
DR   EMBL; BK004234; DAA04632.1; -; Genomic_DNA.
DR   RefSeq; NP_001004453.2; NM_001004453.2.
DR   AlphaFoldDB; Q8NGR2; -.
DR   SMR; Q8NGR2; -.
DR   STRING; 9606.ENSP00000304235; -.
DR   GlyCosmos; Q8NGR2; 1 site, No reported glycans.
DR   GlyGen; Q8NGR2; 1 site.
DR   iPTMnet; Q8NGR2; -.
DR   PhosphoSitePlus; Q8NGR2; -.
DR   BioMuta; OR1L6; -.
DR   DMDM; 229462929; -.
DR   MassIVE; Q8NGR2; -.
DR   PaxDb; 9606-ENSP00000304235; -.
DR   PeptideAtlas; Q8NGR2; -.
DR   Antibodypedia; 64335; 45 antibodies from 14 providers.
DR   DNASU; 392390; -.
DR   Ensembl; ENST00000373684.1; ENSP00000362788.1; ENSG00000171459.4.
DR   GeneID; 392390; -.
DR   KEGG; hsa:392390; -.
DR   UCSC; uc022bna.1; human.
DR   AGR; HGNC:8218; -.
DR   CTD; 392390; -.
DR   GeneCards; OR1L6; -.
DR   HGNC; HGNC:8218; OR1L6.
DR   HPA; ENSG00000171459; Not detected.
DR   neXtProt; NX_Q8NGR2; -.
DR   PharmGKB; PA32087; -.
DR   VEuPathDB; HostDB:ENSG00000171459; -.
DR   eggNOG; ENOG502RTXQ; Eukaryota.
DR   GeneTree; ENSGT00940000165463; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGR2; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGR2; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NGR2; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 392390; 7 hits in 725 CRISPR screens.
DR   GeneWiki; OR1L6; -.
DR   GenomeRNAi; 392390; -.
DR   Pharos; Q8NGR2; Tdark.
DR   PRO; PR:Q8NGR2; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGR2; Protein.
DR   Bgee; ENSG00000171459; Expressed in sural nerve and 1 other tissue.
DR   ExpressionAtlas; Q8NGR2; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15235; 7tmA_OR1A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF106; OLFACTORY RECEPTOR 1L6; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..347
FT                   /note="Olfactory receptor 1L6"
FT                   /id="PRO_0000150445"
FT   TOPO_DOM        1..62
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..86
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..94
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..116
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..137
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..157
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..176
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..195
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        196..233
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..296
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..329
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        330..347
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        134..226
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         59
FT                   /note="Q -> K (in dbSNP:rs10760252)"
FT                   /id="VAR_055056"
FT   VARIANT         186
FT                   /note="C -> Y (in dbSNP:rs4838012)"
FT                   /id="VAR_055057"
FT   VARIANT         251
FT                   /note="I -> T (in dbSNP:rs10985760)"
FT                   /id="VAR_055058"
FT   VARIANT         259
FT                   /note="M -> I (in dbSNP:rs10818741)"
FT                   /id="VAR_055059"
SQ   SEQUENCE   347 AA;  39515 MW;  12DBD2BBC6CD3270 CRC64;
     MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI LLGLSSNPQL
     QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL SNLSFMDICF TTVIVPKMLV
     NFLSETKVIS YVGCLAQMYF FMAFGNTDSY LLASMAIDRL VAICNPLHYD VVMKPRHCLL
     MLLGSCSISH LHSLFRVLLM SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET
     LAVIVTPFLC IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL
     SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR
//