ID   OR9Q1_HUMAN             Reviewed;         310 AA.
AC   Q8NGQ5; Q2TAN3; Q96RA7;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   10-FEB-2021, entry version 147.
DE   RecName: Full=Olfactory receptor 9Q1;
GN   Name=OR9Q1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9Q1";
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DR   EMBL; AB065734; BAC05955.1; -; Genomic_DNA.
DR   EMBL; AF399532; AAK95017.1; -; Genomic_DNA.
DR   EMBL; BC110819; AAI10820.1; -; mRNA.
DR   CCDS; CCDS31543.1; -.
DR   RefSeq; NP_001005212.1; NM_001005212.3.
DR   STRING; 9606.ENSP00000334934; -.
DR   GlyGen; Q8NGQ5; 1 site.
DR   iPTMnet; Q8NGQ5; -.
DR   PhosphoSitePlus; Q8NGQ5; -.
DR   BioMuta; OR9Q1; -.
DR   DMDM; 38372749; -.
DR   PaxDb; Q8NGQ5; -.
DR   PeptideAtlas; Q8NGQ5; -.
DR   PRIDE; Q8NGQ5; -.
DR   ProteomicsDB; 73577; -.
DR   Antibodypedia; 52716; 104 antibodies.
DR   Ensembl; ENST00000335397; ENSP00000334934; ENSG00000186509.
DR   Ensembl; ENST00000612174; ENSP00000479549; ENSG00000186509.
DR   GeneID; 219956; -.
DR   KEGG; hsa:219956; -.
DR   UCSC; uc001nmj.4; human.
DR   CTD; 219956; -.
DR   DisGeNET; 219956; -.
DR   GeneCards; OR9Q1; -.
DR   HGNC; HGNC:14724; OR9Q1.
DR   HPA; ENSG00000186509; Tissue enriched (skeletal).
DR   neXtProt; NX_Q8NGQ5; -.
DR   OpenTargets; ENSG00000186509; -.
DR   PharmGKB; PA32805; -.
DR   VEuPathDB; HostDB:ENSG00000186509.4; -.
DR   eggNOG; ENOG502RF13; Eukaryota.
DR   GeneTree; ENSGT01010000222338; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGQ5; -.
DR   OMA; IAFTEYP; -.
DR   OrthoDB; 1093391at2759; -.
DR   PhylomeDB; Q8NGQ5; -.
DR   TreeFam; TF337111; -.
DR   PathwayCommons; Q8NGQ5; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 219956; 1 hit in 504 CRISPR screens.
DR   ChiTaRS; OR9Q1; human.
DR   GeneWiki; OR9Q1; -.
DR   GenomeRNAi; 219956; -.
DR   Pharos; Q8NGQ5; Tdark.
DR   PRO; PR:Q8NGQ5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGQ5; protein.
DR   Bgee; ENSG00000186509; Expressed in omental fat pad and 4 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Olfactory receptor 9Q1"
FT                   /id="PRO_0000150683"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..310
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         159
FT                   /note="R -> L (in dbSNP:rs12420738)"
FT                   /id="VAR_053260"
SQ   SEQUENCE   310 AA;  34757 MW;  6C27C347AE8FD741 CRC64;
     MAEMNLTLVT EFLLIAFTEY PEWALPLFLL FLFMYLITVL GNLEMIILIL MDHQLHAPMY
     FLLSHLAFMD VCYSSITVPQ MLAVLLEHGA ALSYTRCAAQ FFLFTFFGSI DCYLLALMAY
     DRYLAVCQPL LYVTILTQQA RLSLVAGAYV AGLISALVRT VSAFTLSFCG TSEIDFIFCD
     LPPLLKLTCG ESYTQEVLII MFAIFVIPAS MVVILVSYLF IIVAIMGIPA GSQAKTFSTC
     TSHLTAVSLF FGTLIFMYLR GNSDQSSEKN RVVSVLYTEV IPMLNPLIYS LRNKEVKEAL
     RKILNRAKLS
//