ID O5AR1_HUMAN Reviewed; 310 AA. AC Q8NGP9; Q6IF61; DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 14-DEC-2022, entry version 153. DE RecName: Full=Olfactory receptor 5AR1; DE AltName: Full=Olfactory receptor OR11-209; GN Name=OR5AR1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [3] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). RN [4] RP POLYMORPHISM. RX PubMed=17973576; DOI=10.1371/journal.pbio.0050284; RA Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W., RA Lancet D.; RT "Genetic elucidation of human hyperosmia to isovaleric acid."; RL PLoS Biol. 5:2462-2468(2007). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- POLYMORPHISM: A stop codon in the gene coding for this protein at CC position Gln-19 is responsible for functional diversity thus producing CC a pseudogene. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5AR1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065740; BAC05961.1; -; Genomic_DNA. DR EMBL; BK004401; DAA04799.1; -; Genomic_DNA. DR RefSeq; NP_001004730.1; NM_001004730.1. DR AlphaFoldDB; Q8NGP9; -. DR SMR; Q8NGP9; -. DR STRING; 9606.ENSP00000485424; -. DR GlyGen; Q8NGP9; 1 site. DR iPTMnet; Q8NGP9; -. DR PhosphoSitePlus; Q8NGP9; -. DR BioMuta; OR5AR1; -. DR DMDM; 37081363; -. DR MassIVE; Q8NGP9; -. DR PaxDb; Q8NGP9; -. DR Antibodypedia; 78755; 45 antibodies from 13 providers. DR DNASU; 219493; -. DR Ensembl; ENST00000624596.2; ENSP00000485240.1; ENSG00000172459.5. DR GeneID; 219493; -. DR KEGG; hsa:219493; -. DR MANE-Select; ENST00000624596.2; ENSP00000485240.1; NM_001004730.1; NP_001004730.1. DR UCSC; uc010rjm.2; human. DR AGR; HGNC:15260; -. DR CTD; 219493; -. DR GeneCards; OR5AR1; -. DR HGNC; HGNC:15260; OR5AR1. DR HPA; ENSG00000172459; Not detected. DR neXtProt; NX_Q8NGP9; -. DR PharmGKB; PA32471; -. DR VEuPathDB; HostDB:ENSG00000172459; -. DR eggNOG; ENOG502SHXT; Eukaryota. DR GeneTree; ENSGT01050000244954; -. DR HOGENOM; CLU_012526_1_0_1; -. DR InParanoid; Q8NGP9; -. DR OMA; TGITQDP; -. DR OrthoDB; 963494at2759; -. DR PhylomeDB; Q8NGP9; -. DR TreeFam; TF352753; -. DR PathwayCommons; Q8NGP9; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 219493; 14 hits in 667 CRISPR screens. DR GeneWiki; OR5AR1; -. DR GenomeRNAi; 219493; -. DR Pharos; Q8NGP9; Tdark. DR PRO; PR:Q8NGP9; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q8NGP9; protein. DR ExpressionAtlas; Q8NGP9; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005507; F:copper ion binding; IEA:Ensembl. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0005549; F:odorant binding; IBA:GO_Central. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..310 FT /note="Olfactory receptor 5AR1" FT /id="PRO_0000150579" FT TOPO_DOM 1..28 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 29..49 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 50..58 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 59..79 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 80..100 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 101..120 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 121..139 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 140..160 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 161..205 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 206..226 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 227..239 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 240..260 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 261..271 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 272..292 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 293..310 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 97..189 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 225 FT /note="I -> V (in dbSNP:rs56067375)" FT /id="VAR_062038" SQ SEQUENCE 310 AA; 34815 MW; 660D5C566B330E47 CRC64; MDKENSSMVT EFIFMGITQD PQMEIIFFVV FLIVYLVNVV GNIGMIILIT TDTQLHTPMY FFLCNLSFVD LGYSSAIAPR MLADFLTNHK VISFSSCATQ FAFFVGFVDA ECYVLAAMAY GRFVAICRPL HYSTFMSKQV CLALMLGSYL AGLVSLVAHT TLTFSLSYCG SNIINHFFCE IPPLLALSCS DTYISEILLF SLCGFIEFST ILIIFISYTF ILVAIIRMRS AEGRLKAFST CGSHLTGITL FYGTVMFMYL RPTSSYSLDQ DKWASVFYTV IIPMLNPLIY SLRNKDVKAA FKKLIGKKSQ //