ID O10G4_HUMAN Reviewed; 311 AA. AC Q8NGN3; Q6IEW0; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 02-JUN-2021, entry version 150. DE RecName: Full=Olfactory receptor 10G4; DE AltName: Full=Olfactory receptor OR11-278; GN Name=OR10G4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [3] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- INTERACTION: CC Q8NGN3; Q86XA6: B4GALT1; NbExp=3; IntAct=EBI-17208485, EBI-18325557; CC Q8NGN3; P30050-2: RPL12; NbExp=3; IntAct=EBI-17208485, EBI-17208508; CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G4"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065757; BAC05977.1; -; Genomic_DNA. DR EMBL; BK004502; DAA04900.1; -; Genomic_DNA. DR CCDS; CCDS31702.1; -. DR RefSeq; NP_001004462.1; NM_001004462.1. DR SMR; Q8NGN3; -. DR BioGRID; 133478; 2. DR IntAct; Q8NGN3; 2. DR STRING; 9606.ENSP00000325076; -. DR GlyGen; Q8NGN3; 1 site. DR iPTMnet; Q8NGN3; -. DR PhosphoSitePlus; Q8NGN3; -. DR BioMuta; OR10G4; -. DR DMDM; 38372733; -. DR PaxDb; Q8NGN3; -. DR PeptideAtlas; Q8NGN3; -. DR PRIDE; Q8NGN3; -. DR ProteomicsDB; 73560; -. DR Antibodypedia; 56778; 44 antibodies. DR DNASU; 390264; -. DR Ensembl; ENST00000320891; ENSP00000325076; ENSG00000254737. DR Ensembl; ENST00000641521; ENSP00000493354; ENSG00000254737. DR Ensembl; ENST00000641722; ENSP00000493036; ENSG00000254737. DR GeneID; 390264; -. DR KEGG; hsa:390264; -. DR UCSC; uc010sac.2; human. DR CTD; 390264; -. DR GeneCards; OR10G4; -. DR HGNC; HGNC:14809; OR10G4. DR HPA; ENSG00000254737; Tissue enhanced (bone marrow, pancreas). DR neXtProt; NX_Q8NGN3; -. DR OpenTargets; ENSG00000254737; -. DR PharmGKB; PA31971; -. DR VEuPathDB; HostDB:ENSG00000254737.1; -. DR eggNOG; ENOG502SI4A; Eukaryota. DR GeneTree; ENSGT01020000230329; -. DR HOGENOM; CLU_012526_8_1_1; -. DR InParanoid; Q8NGN3; -. DR OMA; LAIYMFT; -. DR OrthoDB; 1189559at2759; -. DR PhylomeDB; Q8NGN3; -. DR TreeFam; TF337251; -. DR PathwayCommons; Q8NGN3; -. DR Reactome; R-HSA-381753; Olfactory Signaling Pathway. DR BioGRID-ORCS; 390264; 4 hits in 554 CRISPR screens. DR GeneWiki; OR10G4; -. DR GenomeRNAi; 390264; -. DR Pharos; Q8NGN3; Tdark. DR PRO; PR:Q8NGN3; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q8NGN3; protein. DR Bgee; ENSG00000254737; Expressed in body of pancreas and 3 other tissues. DR ExpressionAtlas; Q8NGN3; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR InterPro; IPR030779; 10G4/10G9. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR26453:SF6; PTHR26453:SF6; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..311 FT /note="Olfactory receptor 10G4" FT /id="PRO_0000150697" FT TOPO_DOM 1..23 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 24..44 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 45..52 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 53..73 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 74..98 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 99..119 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 120..138 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 139..159 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 160..196 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 197..216 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 217..236 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 237..257 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 258..268 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 269..289 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 290..311 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 3 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 96..188 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 24 FT /note="L -> P (in dbSNP:rs547068)" FT /id="VAR_053275" FT VARIANT 101 FT /note="Y -> C (in dbSNP:rs4474449)" FT /id="VAR_060025" FT VARIANT 134 FT /note="M -> V (in dbSNP:rs1893766)" FT /id="VAR_053276" FT VARIANT 146 FT /note="G -> C (in dbSNP:rs503223)" FT /id="VAR_060026" FT VARIANT 146 FT /note="G -> R (in dbSNP:rs503223)" FT /id="VAR_060027" FT VARIANT 146 FT /note="G -> S (in dbSNP:rs503223)" FT /id="VAR_060028" FT VARIANT 181 FT /note="P -> S (in dbSNP:rs1893764)" FT /id="VAR_053277" FT VARIANT 195 FT /note="V -> E (in dbSNP:rs4084209)" FT /id="VAR_034283" FT VARIANT 226 FT /note="R -> Q (in dbSNP:rs11219408)" FT /id="VAR_053278" FT VARIANT 235 FT /note="R -> G (in dbSNP:rs4936880)" FT /id="VAR_034284" FT VARIANT 295 FT /note="K -> Q (in dbSNP:rs4936881)" FT /id="VAR_053279" SQ SEQUENCE 311 AA; 34569 MW; A46CBCE6EF461752 CRC64; MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK LRDKVAHPQR K //