ID   OR6M1_HUMAN             Reviewed;         313 AA.
AC   Q8NGM8; B2RNK0; Q6IEW9; Q96R37;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   14-DEC-2022, entry version 148.
DE   RecName: Full=Olfactory receptor 6M1;
DE   AltName: Full=Olfactory receptor OR11-271;
GN   Name=OR6M1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6M1";
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DR   EMBL; AB065762; BAC05982.1; -; Genomic_DNA.
DR   EMBL; CH471065; EAW67556.1; -; Genomic_DNA.
DR   EMBL; BC136929; AAI36930.1; -; mRNA.
DR   EMBL; BC136931; AAI36932.1; -; mRNA.
DR   EMBL; AF399606; AAK95091.1; -; Genomic_DNA.
DR   EMBL; BK004493; DAA04891.1; -; Genomic_DNA.
DR   CCDS; CCDS31696.1; -.
DR   RefSeq; NP_001005325.1; NM_001005325.1.
DR   AlphaFoldDB; Q8NGM8; -.
DR   SMR; Q8NGM8; -.
DR   BioGRID; 133477; 8.
DR   STRING; 9606.ENSP00000311038; -.
DR   GlyGen; Q8NGM8; 2 sites.
DR   iPTMnet; Q8NGM8; -.
DR   PhosphoSitePlus; Q8NGM8; -.
DR   BioMuta; OR6M1; -.
DR   MassIVE; Q8NGM8; -.
DR   PaxDb; Q8NGM8; -.
DR   PeptideAtlas; Q8NGM8; -.
DR   Antibodypedia; 63993; 37 antibodies from 15 providers.
DR   DNASU; 390261; -.
DR   Ensembl; ENST00000309154.3; ENSP00000311038.2; ENSG00000196099.5.
DR   GeneID; 390261; -.
DR   KEGG; hsa:390261; -.
DR   MANE-Select; ENST00000309154.3; ENSP00000311038.2; NM_001005325.1; NP_001005325.1.
DR   UCSC; uc010rzz.3; human.
DR   AGR; HGNC:14711; -.
DR   CTD; 390261; -.
DR   GeneCards; OR6M1; -.
DR   HGNC; HGNC:14711; OR6M1.
DR   HPA; ENSG00000196099; Not detected.
DR   neXtProt; NX_Q8NGM8; -.
DR   PharmGKB; PA32596; -.
DR   VEuPathDB; HostDB:ENSG00000196099; -.
DR   eggNOG; ENOG502SFXX; Eukaryota.
DR   GeneTree; ENSGT01050000244938; -.
DR   HOGENOM; CLU_012526_1_1_1; -.
DR   InParanoid; Q8NGM8; -.
DR   OMA; CRKEINH; -.
DR   OrthoDB; 1140068at2759; -.
DR   PhylomeDB; Q8NGM8; -.
DR   TreeFam; TF336833; -.
DR   PathwayCommons; Q8NGM8; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390261; 8 hits in 671 CRISPR screens.
DR   GeneWiki; OR6M1; -.
DR   GenomeRNAi; 390261; -.
DR   Pharos; Q8NGM8; Tdark.
DR   PRO; PR:Q8NGM8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGM8; protein.
DR   Bgee; ENSG00000196099; Expressed in mucosa of transverse colon and 5 other tissues.
DR   ExpressionAtlas; Q8NGM8; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Olfactory receptor 6M1"
FT                   /id="PRO_0000150632"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..214
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..268
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        262
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..186
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         276
FT                   /note="T -> K (in dbSNP:rs4936845)"
FT                   /id="VAR_053222"
SQ   SEQUENCE   313 AA;  35328 MW;  52794CB2134202CF CRC64;
     MGNWSTVTEI TLIAFPALLE IRISLFVVLV VTYTLTATGN ITIISLIWID HRLQTPMYFF
     LSNLSFLDIL YTTVITPKLL ACLLGEEKTI SFAGCMIQTY FYFFLGTVEF ILLAVMSFDR
     YMAICDPLHY TVIMNSRACL LLVLGCWVGA FLSVLFPTIV VTRLPYCRKE INHFFCDIAP
     LLQVACINTH LIEKINFLLS ALVILSSLAF TTGSYVYIIS TILRIPSTQG RQKAFSTCAS
     HITVVSIAHG SNIFVYVRPN QNSSLDYDKV AAVLITVVTP LLNPFIYSLR NEKVQEVLRE
     TVNRIMTLIQ RKT
//