ID   OR4CF_HUMAN             Reviewed;         316 AA.
AC   Q8NGM1; Q6IFE2;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   08-NOV-2023, entry version 151.
DE   RecName: Full=Olfactory receptor 4C15;
DE   AltName: Full=Olfactory receptor OR11-127;
DE   AltName: Full=Olfactory receptor OR11-134;
GN   Name=OR4C15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA04717.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=DAA04718.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C15";
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DR   EMBL; AB065771; BAC05991.1; -; Genomic_DNA.
DR   EMBL; AP001998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004319; DAA04717.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BK004320; DAA04718.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS31501.2; -.
DR   RefSeq; NP_001001920.1; NM_001001920.1.
DR   AlphaFoldDB; Q8NGM1; -.
DR   SMR; Q8NGM1; -.
DR   BioGRID; 123440; 1.
DR   STRING; 9606.ENSP00000324958; -.
DR   GlyCosmos; Q8NGM1; 1 site, No reported glycans.
DR   GlyGen; Q8NGM1; 1 site.
DR   iPTMnet; Q8NGM1; -.
DR   PhosphoSitePlus; Q8NGM1; -.
DR   BioMuta; OR4C15; -.
DR   DMDM; 38372727; -.
DR   PaxDb; 9606-ENSP00000324958; -.
DR   PeptideAtlas; Q8NGM1; -.
DR   Antibodypedia; 27128; 63 antibodies from 17 providers.
DR   DNASU; 81309; -.
DR   Ensembl; ENST00000642128.1; ENSP00000493126.1; ENSG00000181939.3.
DR   GeneID; 81309; -.
DR   KEGG; hsa:81309; -.
DR   MANE-Select; ENST00000642128.1; ENSP00000493126.1; NM_001001920.3; NP_001001920.2.
DR   UCSC; uc010rig.2; human.
DR   AGR; HGNC:15171; -.
DR   CTD; 81309; -.
DR   DisGeNET; 81309; -.
DR   GeneCards; OR4C15; -.
DR   HGNC; HGNC:15171; OR4C15.
DR   HPA; ENSG00000181939; Not detected.
DR   neXtProt; NX_Q8NGM1; -.
DR   OpenTargets; ENSG00000181939; -.
DR   VEuPathDB; HostDB:ENSG00000181939; -.
DR   eggNOG; ENOG502SIY5; Eukaryota.
DR   GeneTree; ENSGT00900000141017; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGM1; -.
DR   OMA; MGIAWMG; -.
DR   OrthoDB; 4052270at2759; -.
DR   PhylomeDB; Q8NGM1; -.
DR   TreeFam; TF352732; -.
DR   PathwayCommons; Q8NGM1; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 81309; 4 hits in 731 CRISPR screens.
DR   GeneWiki; OR4C15; -.
DR   GenomeRNAi; 81309; -.
DR   Pharos; Q8NGM1; Tdark.
DR   PRO; PR:Q8NGM1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGM1; Protein.
DR   ExpressionAtlas; Q8NGM1; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15939; 7tmA_OR4A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF53; OLFACTORY RECEPTOR 4C15; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Olfactory receptor 4C15"
FT                   /id="PRO_0000150535"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..157
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..268
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..288
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   316 AA;  35667 MW;  9A77A664A489AAE1 CRC64;
     MQNQSFVTEF VLLGLSQNPN VQEIVFVVFL FVYIATVGGN MLIVVTILSS PALLVSPMYF
     FLGFLSFLDA CFSSVITPKM IVDSLYVTKT ISFEGCMMQL FAEHFFAGVE VIVLTAMAYD
     RYVAICKPLH YSSIMNRRLC GILMGVAWTG GLLHSMIQIL FTFQLPFCGP NVINHFMCDL
     YPLLELACTD THIFGLMVVI NSGFICIINF SLLLVSYAVI LLSLRTHSSE GRWKALSTCG
     SHIAVVILFF VPCIFVYTRP PSAFSLDKMA AIFYIILNPL LNPLIYTFRN KEVKQAMRRI
     WNRLMVVSDE KENIKL
//