ID   OR4CG_HUMAN             Reviewed;         310 AA.
AC   Q8NGL9; Q6IEV8;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   27-NOV-2024, entry version 160.
DE   RecName: Full=Olfactory receptor 4C16;
DE   AltName: Full=Olfactory receptor OR11-135;
GN   Name=OR4C16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-49; ALA-76 AND PRO-259.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C16";
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DR   EMBL; AB065773; BAC05993.1; -; Genomic_DNA.
DR   EMBL; AP001998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004504; DAA04902.1; -; Genomic_DNA.
DR   RefSeq; NP_001004701.2; NM_001004701.2.
DR   AlphaFoldDB; Q8NGL9; -.
DR   SMR; Q8NGL9; -.
DR   STRING; 9606.ENSP00000485295; -.
DR   GlyCosmos; Q8NGL9; 1 site, No reported glycans.
DR   GlyGen; Q8NGL9; 1 site.
DR   iPTMnet; Q8NGL9; -.
DR   PhosphoSitePlus; Q8NGL9; -.
DR   BioMuta; OR4C16; -.
DR   DMDM; 83305198; -.
DR   MassIVE; Q8NGL9; -.
DR   PaxDb; 9606-ENSP00000324913; -.
DR   PeptideAtlas; Q8NGL9; -.
DR   ProteomicsDB; 73551; -.
DR   Antibodypedia; 78655; 99 antibodies from 19 providers.
DR   DNASU; 219428; -.
DR   Ensembl; ENST00000623907.1; ENSP00000485295.1; ENSG00000279514.2.
DR   GeneID; 219428; -.
DR   KEGG; hsa:219428; -.
DR   MANE-Select; ENST00000623907.1; ENSP00000485295.1; NM_001004701.2; NP_001004701.2.
DR   UCSC; uc010rih.2; human.
DR   AGR; HGNC:15172; -.
DR   CTD; 219428; -.
DR   GeneCards; OR4C16; -.
DR   HGNC; HGNC:15172; OR4C16.
DR   HPA; ENSG00000279514; Not detected.
DR   neXtProt; NX_Q8NGL9; -.
DR   PharmGKB; PA32258; -.
DR   VEuPathDB; HostDB:ENSG00000279514; -.
DR   eggNOG; ENOG502SHD5; Eukaryota.
DR   GeneTree; ENSGT00940000154976; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NGL9; -.
DR   OMA; MTIMNHQ; -.
DR   OrthoDB; 4052270at2759; -.
DR   PhylomeDB; Q8NGL9; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q8NGL9; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219428; 14 hits in 733 CRISPR screens.
DR   GeneWiki; OR4C16; -.
DR   GenomeRNAi; 219428; -.
DR   Pharos; Q8NGL9; Tdark.
DR   PRO; PR:Q8NGL9; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGL9; protein.
DR   Bgee; ENSG00000279514; Expressed in sural nerve.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15939; 7tmA_OR4A-like; 1.
DR   FunFam; 1.20.1070.10:FF:000007; Olfactory receptor; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   InterPro; IPR050427; Olfactory_Receptors.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF106; OLFACTORY RECEPTOR 4C16; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Olfactory receptor 4C16"
FT                   /id="PRO_0000150536"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..310
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         25
FT                   /note="V -> L (in dbSNP:rs12800642)"
FT                   /id="VAR_053165"
FT   VARIANT         49
FT                   /note="T -> A (in dbSNP:rs558465)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_053166"
FT   VARIANT         76
FT                   /note="T -> A (in dbSNP:rs557590)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_034193"
FT   VARIANT         203
FT                   /note="A -> T (in dbSNP:rs12288690)"
FT                   /id="VAR_053167"
FT   VARIANT         259
FT                   /note="L -> P (in dbSNP:rs559449)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_053168"
SQ   SEQUENCE   310 AA;  34991 MW;  87BA28E6BAB087AF CRC64;
     MQLNNNVTEF ILLGLTQDPF WKKIVFVIFL RLYLGTLLGN LLIIISVKTS QALKNPMFFF
     LFYLSLSDTC LSTSITPRMI VDALLKKTTI SFSECMIQVF SSHVFGCLEI FILILTAVDR
     YVDICKPLHY MTIISQWVCG VLMAVAWVGS CVHSLVQIFL ALSLPFCGPN VINHCFCDLQ
     PLLKQACSET YVVNLLLVSN SGAICAVSYV MLIFSYVIFL HSLRNHSAEV IKKALSTCVS
     HIIVVILFFG PCIFMYTCLA TVFPMDKMIA VFYTVGTSFL NPVIYTLKNT EVKSAMRKLW
     SKKLITDDKR
//