ID   O52K2_HUMAN             Reviewed;         314 AA.
AC   Q8NGK3; A8MUY8; B2RP35; Q6IFK4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   02-DEC-2020, entry version 144.
DE   RecName: Full=Olfactory receptor 52K2;
DE   AltName: Full=Olfactory receptor OR11-7;
GN   Name=OR52K2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT HIS-236.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52K2";
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DR   EMBL; AB065791; BAC06010.1; -; Genomic_DNA.
DR   EMBL; AC010930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471064; EAW68843.1; -; Genomic_DNA.
DR   EMBL; BC137247; AAI37248.1; -; mRNA.
DR   EMBL; BC137248; AAI37249.1; -; mRNA.
DR   EMBL; BK004258; DAA04656.1; -; Genomic_DNA.
DR   CCDS; CCDS31351.1; -.
DR   RefSeq; NP_001005172.2; NM_001005172.2.
DR   STRING; 9606.ENSP00000318956; -.
DR   GlyGen; Q8NGK3; 1 site.
DR   BioMuta; OR52K2; -.
DR   DMDM; 218511725; -.
DR   PaxDb; Q8NGK3; -.
DR   PeptideAtlas; Q8NGK3; -.
DR   PRIDE; Q8NGK3; -.
DR   ProteomicsDB; 73539; -.
DR   Antibodypedia; 57453; 14 antibodies.
DR   Ensembl; ENST00000325719; ENSP00000318956; ENSG00000181963.
DR   GeneID; 119774; -.
DR   KEGG; hsa:119774; -.
DR   UCSC; uc001lyz.2; human.
DR   CTD; 119774; -.
DR   DisGeNET; 119774; -.
DR   EuPathDB; HostDB:ENSG00000181963.5; -.
DR   GeneCards; OR52K2; -.
DR   HGNC; HGNC:15223; OR52K2.
DR   HPA; ENSG00000181963; Group enriched (blood, bone marrow).
DR   neXtProt; NX_Q8NGK3; -.
DR   OpenTargets; ENSG00000181963; -.
DR   PharmGKB; PA32418; -.
DR   eggNOG; ENOG502SHN8; Eukaryota.
DR   GeneTree; ENSGT01010000222253; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8NGK3; -.
DR   OMA; RVIAHCY; -.
DR   OrthoDB; 999758at2759; -.
DR   PhylomeDB; Q8NGK3; -.
DR   TreeFam; TF343679; -.
DR   PathwayCommons; Q8NGK3; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 119774; 3 hits in 455 CRISPR screens.
DR   ChiTaRS; OR52K2; human.
DR   GeneWiki; OR52K2; -.
DR   GenomeRNAi; 119774; -.
DR   Pharos; Q8NGK3; Tdark.
DR   PRO; PR:Q8NGK3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGK3; protein.
DR   Bgee; ENSG00000181963; Expressed in colon and 9 other tissues.
DR   ExpressionAtlas; Q8NGK3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Polymorphism; Receptor; Reference proteome;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 52K2"
FT                   /id="PRO_0000150782"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         124
FT                   /note="R -> C (in dbSNP:rs11032296)"
FT                   /id="VAR_034347"
FT   VARIANT         236
FT                   /note="R -> H (in dbSNP:rs331537)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_047827"
FT   VARIANT         302
FT                   /note="R -> C (in dbSNP:rs7934336)"
FT                   /id="VAR_034348"
SQ   SEQUENCE   314 AA;  34926 MW;  CCA5A033E904A0B6 CRC64;
     MSASNITLTH PTAFLLVGIP GLEHLHIWIS IPFCLAYTLA LLGNCTLLLI IQADAALHEP
     MYLFLAMLAA IDLVLSSSAL PKMLAIFWFR DREINFFACL AQMFFLHSFS IMESAVLLAM
     AFDRYVAICK PLHYTKVLTG SLITKIGMAA VARAVTLMTP LPFLLRCFHY CRGPVIAHCY
     CEHMAVVRLA CGDTSFNNIY GIAVAMFIVV LDLLLVILSY IFILQAVLLL ASQEARYKAF
     GTCVSHIGAI LAFYTTVVIS SVMHRVARHA APHVHILLAN FYLLFPPMVN PIIYGVKTKQ
     IRESILGVFP RKDM
//