ID   OR5A1_HUMAN             Reviewed;         315 AA.
AC   Q8NGJ0; B9EH58; Q6IFF2; Q96RB1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   23-FEB-2022, entry version 153.
DE   RecName: Full=Olfactory receptor 5A1;
DE   AltName: Full=OST181;
DE   AltName: Full=Olfactory receptor OR11-249;
GN   Name=OR5A1; Synonyms=OR5A1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-183.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5A1";
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DR   EMBL; AB065804; BAC06023.1; -; Genomic_DNA.
DR   EMBL; CH471076; EAW73844.1; -; Genomic_DNA.
DR   EMBL; BC137060; AAI37061.1; -; mRNA.
DR   EMBL; BC137061; AAI37062.1; -; mRNA.
DR   EMBL; AF399528; AAK95013.1; -; Genomic_DNA.
DR   EMBL; BK004310; DAA04708.1; -; Genomic_DNA.
DR   CCDS; CCDS31561.1; -.
DR   RefSeq; NP_001004728.1; NM_001004728.1.
DR   SMR; Q8NGJ0; -.
DR   IntAct; Q8NGJ0; 1.
DR   STRING; 9606.ENSP00000303096; -.
DR   GlyGen; Q8NGJ0; 1 site.
DR   iPTMnet; Q8NGJ0; -.
DR   PhosphoSitePlus; Q8NGJ0; -.
DR   BioMuta; OR5A1; -.
DR   DMDM; 38372702; -.
DR   MassIVE; Q8NGJ0; -.
DR   PaxDb; Q8NGJ0; -.
DR   PeptideAtlas; Q8NGJ0; -.
DR   PRIDE; Q8NGJ0; -.
DR   ProteomicsDB; 73526; -.
DR   Antibodypedia; 58822; 43 antibodies from 16 providers.
DR   DNASU; 219982; -.
DR   Ensembl; ENST00000641045; ENSP00000493195; ENSG00000172320.
DR   GeneID; 219982; -.
DR   KEGG; hsa:219982; -.
DR   MANE-Select; ENST00000641045.1; ENSP00000493195.1; NM_001004728.2; NP_001004728.1.
DR   UCSC; uc001nnx.2; human.
DR   CTD; 219982; -.
DR   GeneCards; OR5A1; -.
DR   HGNC; HGNC:8319; OR5A1.
DR   HPA; ENSG00000172320; Tissue enhanced (brain).
DR   neXtProt; NX_Q8NGJ0; -.
DR   PharmGKB; PA32454; -.
DR   VEuPathDB; HostDB:ENSG00000172320; -.
DR   eggNOG; ENOG502SMFV; Eukaryota.
DR   GeneTree; ENSGT01040000240391; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGJ0; -.
DR   OMA; SQGLCTR; -.
DR   OrthoDB; 921007at2759; -.
DR   PhylomeDB; Q8NGJ0; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q8NGJ0; -.
DR   SignaLink; Q8NGJ0; -.
DR   BioGRID-ORCS; 219982; 15 hits in 636 CRISPR screens.
DR   GeneWiki; OR5A1; -.
DR   GenomeRNAi; 219982; -.
DR   Pharos; Q8NGJ0; Tdark.
DR   PRO; PR:Q8NGJ0; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGJ0; protein.
DR   Bgee; ENSG00000172320; Expressed in prefrontal cortex and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 5A1"
FT                   /id="PRO_0000150572"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..82
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        83..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..123
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..262
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..295
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..192
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         52
FT                   /note="I -> V (in dbSNP:rs17153732)"
FT                   /id="VAR_034213"
FT   VARIANT         183
FT                   /note="D -> N (in dbSNP:rs6591536)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_024096"
SQ   SEQUENCE   315 AA;  35152 MW;  EF096B7068244DC5 CRC64;
     MSITKAWNSS SVTMFILLGF TDHPELQALL FVTFLGIYLT TLAWNLALIF LIRGDTHLHT
     PMYFFLSNLS FIDICYSSAV APNMLTDFFW EQKTISFVGC AAQFFFFVGM GLSECLLLTA
     MAYDRYAAIS SPLLYPTIMT QGLCTRMVVG AYVGGFLSSL IQASSIFRLH FCGPNIINHF
     FCDLPPVLAL SCSDTFLSQV VNFLVVVTVG GTSFLQLLIS YGYIVSAVLK IPSAEGRWKA
     CNTCASHLMV VTLLFGTALF VYLRPSSSYL LGRDKVVSVF YSLVIPMLNP LIYSLRNKEI
     KDALWKVLER KKVFS
//