ID OR5A2_HUMAN Reviewed; 324 AA. AC Q8NGI9; B9EH21; Q6IFF4; Q96RB0; DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 08-NOV-2023, entry version 157. DE RecName: Full=Olfactory receptor 5A2; DE AltName: Full=Olfactory receptor OR11-248; GN Name=OR5A2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-285. RX PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [5] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [6] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5A2"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065805; BAC06024.1; -; Genomic_DNA. DR EMBL; CH471076; EAW73843.1; -; Genomic_DNA. DR EMBL; BC136991; AAI36992.1; -; mRNA. DR EMBL; AF399529; AAK95014.1; -; Genomic_DNA. DR EMBL; BK004308; DAA04706.1; -; Genomic_DNA. DR CCDS; CCDS31560.1; -. DR RefSeq; NP_001001954.1; NM_001001954.1. DR AlphaFoldDB; Q8NGI9; -. DR SMR; Q8NGI9; -. DR BioGRID; 128609; 3. DR IntAct; Q8NGI9; 3. DR STRING; 9606.ENSP00000303834; -. DR GlyCosmos; Q8NGI9; 1 site, No reported glycans. DR GlyGen; Q8NGI9; 1 site. DR iPTMnet; Q8NGI9; -. DR PhosphoSitePlus; Q8NGI9; -. DR BioMuta; OR5A2; -. DR DMDM; 37081361; -. DR MaxQB; Q8NGI9; -. DR PaxDb; 9606-ENSP00000303834; -. DR PeptideAtlas; Q8NGI9; -. DR ProteomicsDB; 73525; -. DR Antibodypedia; 58820; 55 antibodies from 17 providers. DR DNASU; 219981; -. DR Ensembl; ENST00000302040.6; ENSP00000303834.4; ENSG00000172324.6. DR Ensembl; ENST00000641361.1; ENSP00000493065.1; ENSG00000172324.6. DR Ensembl; ENST00000641673.1; ENSP00000492975.1; ENSG00000172324.6. DR GeneID; 219981; -. DR KEGG; hsa:219981; -. DR MANE-Select; ENST00000302040.6; ENSP00000303834.4; NM_001001954.2; NP_001001954.1. DR UCSC; uc010rkt.3; human. DR AGR; HGNC:15249; -. DR CTD; 219981; -. DR DisGeNET; 219981; -. DR GeneCards; OR5A2; -. DR HGNC; HGNC:15249; OR5A2. DR HPA; ENSG00000172324; Low tissue specificity. DR neXtProt; NX_Q8NGI9; -. DR OpenTargets; ENSG00000172324; -. DR PharmGKB; PA32455; -. DR VEuPathDB; HostDB:ENSG00000172324; -. DR eggNOG; ENOG502SMFV; Eukaryota. DR GeneTree; ENSGT01090000260063; -. DR HOGENOM; CLU_012526_8_1_1; -. DR InParanoid; Q8NGI9; -. DR OMA; VQYFVFC; -. DR OrthoDB; 4630823at2759; -. DR PhylomeDB; Q8NGI9; -. DR TreeFam; TF352753; -. DR PathwayCommons; Q8NGI9; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR SignaLink; Q8NGI9; -. DR BioGRID-ORCS; 219981; 16 hits in 751 CRISPR screens. DR GeneWiki; OR5A2; -. DR GenomeRNAi; 219981; -. DR Pharos; Q8NGI9; Tdark. DR PRO; PR:Q8NGI9; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q8NGI9; Protein. DR ExpressionAtlas; Q8NGI9; differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0005549; F:odorant binding; IBA:GO_Central. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR CDD; cd15417; 7tmA_OR5A1-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48018:SF105; OLFACTORY RECEPTOR; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..324 FT /note="Olfactory receptor 5A2" FT /id="PRO_0000150573" FT TOPO_DOM 1..26 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 27..47 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 48..55 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 56..76 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 77..100 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 101..121 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 122..134 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 135..155 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 156..197 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 198..218 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 219..238 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 239..259 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 260..272 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 273..293 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 294..324 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 6 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 98..190 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 103 FT /note="F -> L (in dbSNP:rs17153691)" FT /id="VAR_048045" FT VARIANT 172 FT /note="P -> L (in dbSNP:rs1453547)" FT /id="VAR_024097" SQ SEQUENCE 324 AA; 36016 MW; 2801C8878490C486 CRC64; MAVGRNNTIV TKFILLGLSD HPQMKIFLFM LFLGLYLLTL AWNLSLIALI KMDSHLHMPM YFFLSNLSFL DICYVSSTAP KMLSDIITEQ KTISFVGCAT QYFVFCGMGL TECFLLAAMA YDRYAAICNP LLYTVLISHT LCLKMVVGAY VGGFLSSFIE TYSVYQHDFC GPYMINHFFC DLPPVLALSC SDTFTSEVVT FIVSVVVGIV SVLVVLISYG YIVAAVVKIS SATGRTKAFS TCASHLTAVT LFYGSGFFMY MRPSSSYSLN RDKVVSIFYA LVIPVVNPII YSFRNKEIKN AMRKAMERDP GISHGGPFIF MTLG //