ID   OR2D3_HUMAN             Reviewed;         330 AA.
AC   Q8NGH3; B2RP06; Q6IFG8; Q96R51;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   22-APR-2020, entry version 141.
DE   RecName: Full=Olfactory receptor 2D3;
DE   AltName: Full=Olfactory receptor OR11-89;
GN   Name=OR2D3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TRP-155.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-299.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC06044.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2D3";
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DR   EMBL; AB065825; BAC06044.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BC137208; AAI37209.1; -; mRNA.
DR   EMBL; BC137209; AAI37210.1; -; mRNA.
DR   EMBL; AF399592; AAK95077.1; -; Genomic_DNA.
DR   EMBL; BK004294; DAA04692.1; -; Genomic_DNA.
DR   CCDS; CCDS31417.1; -.
DR   RefSeq; NP_001004684.1; NM_001004684.1.
DR   STRING; 9606.ENSP00000320560; -.
DR   iPTMnet; Q8NGH3; -.
DR   PhosphoSitePlus; Q8NGH3; -.
DR   BioMuta; OR2D3; -.
DR   DMDM; 223590116; -.
DR   PaxDb; Q8NGH3; -.
DR   PeptideAtlas; Q8NGH3; -.
DR   PRIDE; Q8NGH3; -.
DR   ProteomicsDB; 73511; -.
DR   Antibodypedia; 23971; 60 antibodies.
DR   Ensembl; ENST00000317834; ENSP00000320560; ENSG00000178358.
DR   GeneID; 120775; -.
DR   KEGG; hsa:120775; -.
DR   UCSC; uc010rav.3; human.
DR   CTD; 120775; -.
DR   GeneCards; OR2D3; -.
DR   HGNC; HGNC:15146; OR2D3.
DR   HPA; ENSG00000178358; Not detected.
DR   neXtProt; NX_Q8NGH3; -.
DR   PharmGKB; PA32153; -.
DR   eggNOG; ENOG410IVFF; Eukaryota.
DR   eggNOG; ENOG41114MT; LUCA.
DR   GeneTree; ENSGT00980000198508; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGH3; -.
DR   KO; K04257; -.
DR   OMA; TFHLPYW; -.
DR   OrthoDB; 1020339at2759; -.
DR   PhylomeDB; Q8NGH3; -.
DR   TreeFam; TF337251; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   GeneWiki; OR2D3; -.
DR   GenomeRNAi; 120775; -.
DR   Pharos; Q8NGH3; Tdark.
DR   PRO; PR:Q8NGH3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGH3; protein.
DR   Bgee; ENSG00000178358; Expressed in corpus callosum and 2 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Polymorphism; Receptor; Reference proteome;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Olfactory receptor 2D3"
FT                   /id="PRO_0000150468"
FT   TOPO_DOM        1..41
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..65
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..73
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..95
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..116
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..155
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..174
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..235
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..252
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..275
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..288
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..308
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        309..330
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        21
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         82
FT                   /note="L -> I (in dbSNP:rs10839658)"
FT                   /id="VAR_057537"
FT   VARIANT         155
FT                   /note="R -> W (in dbSNP:rs12806437)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_057538"
FT   VARIANT         165
FT                   /note="W -> S (in dbSNP:rs10839659)"
FT                   /id="VAR_057539"
SQ   SEQUENCE   330 AA;  37489 MW;  A829F400F34E3DEB CRC64;
     MCSFFLCQTG KQAKISMGEE NQTFVSKFIF LGLSQDLQTQ ILLFILFLII YLLTVLGNQL
     IIILIFLDSR LHTPMYFFLR NLSFADLCFS TSIVPQVLVH FLVKRKTISF YGCMTQIIVF
     LLVGCTECAL LAVMSYDRYV AVCKPLYYST IMTQRVCLWL SFRSWASGAL VSLVDTSFTF
     HLPYWGQNII NHYFCEPPAL LKLASIDTYS TEMAIFSMGV VILLAPVSLI LGSYWNIIST
     VIQMQSGEGR LKAFSTCGSH LIVVVLFYGS GIFTYMRPNS KTTKELDKMI SVFYTAVTPM
     LNPIIYSLRN KDVKGALRKL VGRKCFSHRQ
//