ID   OR8A1_HUMAN             Reviewed;         326 AA.
AC   Q8NGG7; Q6IEW7; Q96RC6;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   10-FEB-2021, entry version 149.
DE   RecName: Full=Olfactory receptor 8A1;
DE   AltName: Full=OST025;
DE   AltName: Full=Olfactory receptor OR11-318;
GN   Name=OR8A1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-299.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [7]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC06052.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8A1";
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DR   EMBL; AB065833; BAC06052.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AP000916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW67586.1; -; Genomic_DNA.
DR   EMBL; BC137194; AAI37195.1; -; mRNA.
DR   EMBL; BC137197; AAI37198.1; -; mRNA.
DR   EMBL; AF399512; AAK94997.1; -; Genomic_DNA.
DR   EMBL; BK004495; DAA04893.1; -; Genomic_DNA.
DR   RefSeq; NP_001005194.1; NM_001005194.1.
DR   SMR; Q8NGG7; -.
DR   STRING; 9606.ENSP00000284287; -.
DR   GlyGen; Q8NGG7; 1 site.
DR   PhosphoSitePlus; Q8NGG7; -.
DR   BioMuta; OR8A1; -.
DR   DMDM; 212276454; -.
DR   PaxDb; Q8NGG7; -.
DR   PRIDE; Q8NGG7; -.
DR   ProteomicsDB; 73509; -.
DR   Antibodypedia; 56821; 58 antibodies.
DR   Ensembl; ENST00000642111; ENSP00000492999; ENSG00000196119.
DR   GeneID; 390275; -.
DR   KEGG; hsa:390275; -.
DR   UCSC; uc010san.3; human.
DR   CTD; 390275; -.
DR   DisGeNET; 390275; -.
DR   GeneCards; OR8A1; -.
DR   HGNC; HGNC:8469; OR8A1.
DR   HPA; ENSG00000196119; Low tissue specificity.
DR   neXtProt; NX_Q8NGG7; -.
DR   OpenTargets; ENSG00000196119; -.
DR   PharmGKB; PA32744; -.
DR   VEuPathDB; HostDB:ENSG00000196119.6; -.
DR   eggNOG; ENOG502T9KS; Eukaryota.
DR   GeneTree; ENSGT01010000222314; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGG7; -.
DR   OMA; MSHPVCS; -.
DR   OrthoDB; 936657at2759; -.
DR   PhylomeDB; Q8NGG7; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q8NGG7; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 390275; 59 hits in 509 CRISPR screens.
DR   GeneWiki; OR8A1; -.
DR   GenomeRNAi; 390275; -.
DR   Pharos; Q8NGG7; Tdark.
DR   PRO; PR:Q8NGG7; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGG7; protein.
DR   Bgee; ENSG00000196119; Expressed in testis and 3 other tissues.
DR   ExpressionAtlas; Q8NGG7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Olfactory receptor 8A1"
FT                   /id="PRO_0000150653"
FT   TOPO_DOM        1..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..100
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..116
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..222
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..287
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        309..326
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        114..195
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         133
FT                   /note="T -> R (in dbSNP:rs55861866)"
FT                   /id="VAR_062057"
FT   VARIANT         218
FT                   /note="S -> L (in dbSNP:rs12792184)"
FT                   /id="VAR_053238"
SQ   SEQUENCE   326 AA;  36388 MW;  B939AB0E17796279 CRC64;
     MGFLSPMHPC RPPTQRRMAA GNHSTVTEFI LKGLTKRADL QLPLFLLFLG IYLVTIVGNL
     GMITLICLNS QLHTPMYYFL SNLSLMDLCY SSVITPKMLV NFVSEKNIIS YAGCMSQLYF
     FLVFVIAECY MLTVMAYDRY VAICHPLLYN IIMSHHTCLL LVAVVYAIGL IGSTIETGLM
     LKLPYCEHLI SHYFCDILPL MKLSCSSTYD VEMTVFFSAG FNIIVTSLTV LVSYTFILSS
     ILGISTTEGR SKAFSTCSSH LAAVGMFYGS TAFMYLKPST ISSLTQENVA SVFYTTVIPM
     LNPLIYSLRN KEVKAAVQKT LRGKLF
//