ID   OR8K1_HUMAN             Reviewed;         319 AA.
AC   Q8NGG5; B9EJB1; Q6IFC3; Q96RC1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   17-JUN-2020, entry version 142.
DE   RecName: Full=Olfactory receptor 8K1;
DE   AltName: Full=Olfactory receptor OR11-182;
GN   Name=OR8K1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-84.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-289.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8K1";
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DR   EMBL; AB065835; BAC06054.1; -; Genomic_DNA.
DR   EMBL; BC146844; AAI46845.1; -; mRNA.
DR   EMBL; AF399517; AAK95002.1; -; Genomic_DNA.
DR   EMBL; BK004339; DAA04737.1; -; Genomic_DNA.
DR   CCDS; CCDS31528.1; -.
DR   RefSeq; NP_001002907.1; NM_001002907.1.
DR   STRING; 9606.ENSP00000279783; -.
DR   BioMuta; OR8K1; -.
DR   DMDM; 38372688; -.
DR   PaxDb; Q8NGG5; -.
DR   PeptideAtlas; Q8NGG5; -.
DR   PRIDE; Q8NGG5; -.
DR   ProteomicsDB; 73507; -.
DR   Antibodypedia; 58977; 88 antibodies.
DR   Ensembl; ENST00000279783; ENSP00000279783; ENSG00000150261.
DR   Ensembl; ENST00000574800; ENSP00000461384; ENSG00000263328.
DR   GeneID; 390157; -.
DR   KEGG; hsa:390157; -.
DR   UCSC; uc010rjg.2; human.
DR   CTD; 390157; -.
DR   EuPathDB; HostDB:ENSG00000150261.3; -.
DR   GeneCards; OR8K1; -.
DR   HGNC; HGNC:14831; OR8K1.
DR   HPA; ENSG00000150261; Not detected.
DR   neXtProt; NX_Q8NGG5; -.
DR   PharmGKB; PA32775; -.
DR   eggNOG; ENOG410IK5R; Eukaryota.
DR   eggNOG; ENOG4111AZY; LUCA.
DR   GeneTree; ENSGT00950000182718; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGG5; -.
DR   KO; K04257; -.
DR   OMA; PLMSILC; -.
DR   OrthoDB; 993549at2759; -.
DR   PhylomeDB; Q8NGG5; -.
DR   TreeFam; TF352753; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 390157; 26 hits in 425 CRISPR screens.
DR   GeneWiki; OR8K1; -.
DR   GenomeRNAi; 390157; -.
DR   Pharos; Q8NGG5; Tdark.
DR   PRO; PR:Q8NGG5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGG5; protein.
DR   ExpressionAtlas; Q8NGG5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Polymorphism; Receptor; Reference proteome;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Olfactory receptor 8K1"
FT                   /id="PRO_0000150671"
FT   TOPO_DOM        1..31
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..203
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         21
FT                   /note="M -> V (in dbSNP:rs10896271)"
FT                   /id="VAR_034270"
FT   VARIANT         27
FT                   /note="P -> T (in dbSNP:rs10896272)"
FT                   /id="VAR_034271"
FT   VARIANT         84
FT                   /note="A -> T (in dbSNP:rs17614327)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_034272"
SQ   SEQUENCE   319 AA;  36581 MW;  9CB4F7F94917E9D5 CRC64;
     MNHVVKHNHT AVTKVTEFIL MGITDNPGLQ APLFGLFLII YLVTVIGNLG MVILTYLDSK
     LHTPMYFFLR HLSITDLGYS TVIAPKMLVN FIVHKNTISY NWYATQLAFF EIFIISELFI
     LSAMAYDRYV AICKPLLYVI IMAEKVLWVL VIVPYLYSTF VSLFLTIKLF KLSFCGSNII
     SYFYCDCIPL MSILCSDTNE LELIILIFSG CNLLFSLSIV LISYMFILVA ILRMNSRKGR
     YKAFSTCSSH LTVVIMFYGT LLFIYLQPKS SHTLAIDKMA SVFYTLLIPM LNPLIYSLRN
     KEVKDALKRT LTNRFKIPI
//