ID   O52B6_HUMAN             Reviewed;         335 AA.
AC   Q8NGF0; Q6IFI7;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 3.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Olfactory receptor 52B6;
DE   AltName: Full=Olfactory receptor OR11-47;
GN   Name=OR52B6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-22 is the initiator.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52B6";
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DR   EMBL; AB065858; BAC06076.1; -; Genomic_DNA.
DR   EMBL; AC015691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004275; DAA04673.1; -; Genomic_DNA.
DR   CCDS; CCDS41611.1; -.
DR   RefSeq; NP_001005162.2; NM_001005162.2.
DR   AlphaFoldDB; Q8NGF0; -.
DR   SMR; Q8NGF0; -.
DR   STRING; 9606.ENSP00000341581; -.
DR   GlyGen; Q8NGF0; 1 site.
DR   iPTMnet; Q8NGF0; -.
DR   PhosphoSitePlus; Q8NGF0; -.
DR   BioMuta; OR52B6; -.
DR   DMDM; 218512128; -.
DR   PaxDb; Q8NGF0; -.
DR   PeptideAtlas; Q8NGF0; -.
DR   PRIDE; Q8NGF0; -.
DR   Antibodypedia; 70926; 28 antibodies from 14 providers.
DR   DNASU; 340980; -.
DR   Ensembl; ENST00000345043.2; ENSP00000341581.2; ENSG00000187747.2.
DR   GeneID; 340980; -.
DR   KEGG; hsa:340980; -.
DR   MANE-Select; ENST00000345043.2; ENSP00000341581.2; NM_001005162.2; NP_001005162.2.
DR   UCSC; uc010qzi.2; human.
DR   CTD; 340980; -.
DR   GeneCards; OR52B6; -.
DR   HGNC; HGNC:15211; OR52B6.
DR   HPA; ENSG00000187747; Not detected.
DR   neXtProt; NX_Q8NGF0; -.
DR   PharmGKB; PA32400; -.
DR   VEuPathDB; HostDB:ENSG00000187747; -.
DR   eggNOG; ENOG502QV28; Eukaryota.
DR   GeneTree; ENSGT01000000214548; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8NGF0; -.
DR   OMA; FIIMFPS; -.
DR   OrthoDB; 919170at2759; -.
DR   PhylomeDB; Q8NGF0; -.
DR   TreeFam; TF343679; -.
DR   PathwayCommons; Q8NGF0; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 340980; 6 hits in 671 CRISPR screens.
DR   GeneWiki; OR52B6; -.
DR   GenomeRNAi; 340980; -.
DR   Pharos; Q8NGF0; Tdark.
DR   PRO; PR:Q8NGF0; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGF0; protein.
DR   Bgee; ENSG00000187747; Expressed in sural nerve and 6 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Olfactory receptor 52B6"
FT                   /id="PRO_0000150769"
FT   TOPO_DOM        1..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..119
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..139
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..215
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        237..256
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        278..293
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        315..335
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        117..208
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         57
FT                   /note="T -> A (in dbSNP:rs1077126)"
FT                   /id="VAR_048077"
FT   VARIANT         111
FT                   /note="L -> H (in dbSNP:rs2341432)"
FT                   /id="VAR_048078"
FT   VARIANT         167
FT                   /note="A -> T (in dbSNP:rs2341433)"
FT                   /id="VAR_048079"
FT   VARIANT         170
FT                   /note="H -> R (in dbSNP:rs2341434)"
FT                   /id="VAR_048080"
FT   VARIANT         288
FT                   /note="V -> I (in dbSNP:rs10769086)"
FT                   /id="VAR_048081"
SQ   SEQUENCE   335 AA;  36963 MW;  F1F3458611158252 CRC64;
     MAQVRALHKI MALFSANSIG AMNNSDTRIA GCFLTGIPGL EQLHIWLSIP FCIMYITALE
     GNGILICVIL SQAILHEPMY IFLSMLASAD VLLSTTTMPK ALANLWLGYS LISFDGCLTQ
     MFFIHFLFIH SAVLLAMAFD RYVAICSPLR YVTILTSKVI GKIVTAALSH SFIIMFPSIF
     LLEHLHYCQI NIIAHTFCEH MGIAHLSCSD ISINVWYGLA AALLSTGLDI MLITVSYIHI
     LQAVFRLLSQ DARSKALSTC GSHICVILLF YVPALFSVFA YRFGGRSVPC YVHILLASLY
     VVIPPMLNPV IYGVRTKPIL EGAKQMFSNL AKGSK
//