ID OR4KE_HUMAN Reviewed; 310 AA. AC Q8NGD5; Q6IEU1; Q96R71; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 24-JUL-2024, entry version 163. DE RecName: Full=Olfactory receptor 4K14; DE AltName: Full=Olfactory receptor OR14-22; GN Name=OR4K14; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-282. RX PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [3] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [4] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4K14"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065880; BAC06098.1; -; Genomic_DNA. DR EMBL; AF399572; AAK95057.1; -; Genomic_DNA. DR EMBL; BK004521; DAA04919.1; -; Genomic_DNA. DR CCDS; CCDS32027.1; -. DR RefSeq; NP_001004712.1; NM_001004712.1. DR AlphaFoldDB; Q8NGD5; -. DR SMR; Q8NGD5; -. DR BioGRID; 125790; 1. DR STRING; 9606.ENSP00000493106; -. DR GlyCosmos; Q8NGD5; 1 site, No reported glycans. DR GlyGen; Q8NGD5; 1 site. DR PhosphoSitePlus; Q8NGD5; -. DR BioMuta; OR4K14; -. DR DMDM; 38372675; -. DR PaxDb; 9606-ENSP00000305011; -. DR PeptideAtlas; Q8NGD5; -. DR ProteomicsDB; 73485; -. DR Antibodypedia; 57315; 136 antibodies from 19 providers. DR DNASU; 122740; -. DR Ensembl; ENST00000641793.1; ENSP00000493106.1; ENSG00000169484.4. DR Ensembl; ENST00000708837.1; ENSP00000517368.1; ENSG00000291805.1. DR GeneID; 122740; -. DR KEGG; hsa:122740; -. DR MANE-Select; ENST00000641793.1; ENSP00000493106.1; NM_001004712.2; NP_001004712.1. DR UCSC; uc010tky.3; human. DR AGR; HGNC:15352; -. DR CTD; 122740; -. DR GeneCards; OR4K14; -. DR HGNC; HGNC:15352; OR4K14. DR HPA; ENSG00000169484; Not detected. DR neXtProt; NX_Q8NGD5; -. DR PharmGKB; PA32313; -. DR VEuPathDB; HostDB:ENSG00000169484; -. DR eggNOG; ENOG502SK03; Eukaryota. DR GeneTree; ENSGT00940000163733; -. DR HOGENOM; CLU_012526_8_1_1; -. DR InParanoid; Q8NGD5; -. DR OMA; CLHSSPM; -. DR OrthoDB; 4631577at2759; -. DR PhylomeDB; Q8NGD5; -. DR TreeFam; TF337251; -. DR PathwayCommons; Q8NGD5; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 122740; 3 hits in 748 CRISPR screens. DR GeneWiki; OR4K14; -. DR GenomeRNAi; 122740; -. DR Pharos; Q8NGD5; Tdark. DR PRO; PR:Q8NGD5; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; Q8NGD5; Protein. DR ExpressionAtlas; Q8NGD5; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR CDD; cd15226; 7tmA_OR4-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR InterPro; IPR050427; Olfactory_Receptors. DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48002:SF115; OLFACTORY RECEPTOR 4K14; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..310 FT /note="Olfactory receptor 4K14" FT /id="PRO_0000150557" FT TOPO_DOM 1..25 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 26..49 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 50..58 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 59..80 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 81..101 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 102..121 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 122..140 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 141..159 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 160..196 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 197..220 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 221..236 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 237..259 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 260..270 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 271..290 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 291..310 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 98..190 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 119 FT /note="M -> V (in dbSNP:rs7157076)" FT /id="VAR_053173" FT VARIANT 145 FT /note="L -> R (in dbSNP:rs17308108)" FT /id="VAR_053174" SQ SEQUENCE 310 AA; 35053 MW; AA7B06959BFE8E0D CRC64; MDPQNYSLVS EFVLHGLCTS RHLQNFFFIF FFGVYVAIML GNLLILVTVI SDPCLHSSPM YFLLGNLAFL DMWLASFATP KMIRDFLSDQ KLISFGGCMA QIFFLHFTGG AEMVLLVSMA YDRYVAICKP LHYMTLMSWQ TCIRLVLASW VVGFVHSISQ VAFTVNLPYC GPNEVDSFFC DLPLVIKLAC MDTYVLGIIM ISDSGLLSLS CFLLLLISYT VILLAIRQRA AGSTSKALST CSAHIMVVTL FFGPCIFVYV RPFSRFSVDK LLSVFYTIFT PLLNPIIYTL RNEEMKAAMK KLQNRRVTFQ //