ID   OR4F6_HUMAN             Reviewed;         312 AA.
AC   Q8NGB9; B9EH28; Q6IF95;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   23-FEB-2022, entry version 145.
DE   RecName: Full=Olfactory receptor 4F6;
DE   AltName: Full=Olfactory receptor 4F12;
DE   AltName: Full=Olfactory receptor OR15-15;
GN   Name=OR4F6; Synonyms=OR4F12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F6";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065899; BAC06115.1; -; Genomic_DNA.
DR   EMBL; CH471101; EAX02319.1; -; Genomic_DNA.
DR   EMBL; BC137002; AAI37003.1; -; mRNA.
DR   EMBL; BC137003; AAI37004.1; -; mRNA.
DR   EMBL; BK004367; DAA04765.1; -; Genomic_DNA.
DR   CCDS; CCDS32341.1; -.
DR   RefSeq; NP_001005326.1; NM_001005326.1.
DR   SMR; Q8NGB9; -.
DR   STRING; 9606.ENSP00000327525; -.
DR   GlyGen; Q8NGB9; 1 site.
DR   BioMuta; OR4F6; -.
DR   DMDM; 38372660; -.
DR   PaxDb; Q8NGB9; -.
DR   PeptideAtlas; Q8NGB9; -.
DR   PRIDE; Q8NGB9; -.
DR   Antibodypedia; 56268; 43 antibodies from 16 providers.
DR   DNASU; 390648; -.
DR   Ensembl; ENST00000328882; ENSP00000327525; ENSG00000184140.
DR   GeneID; 390648; -.
DR   KEGG; hsa:390648; -.
DR   MANE-Select; ENST00000328882.6; ENSP00000327525.4; NM_001005326.2; NP_001005326.1.
DR   UCSC; uc010utr.3; human.
DR   CTD; 390648; -.
DR   GeneCards; OR4F6; -.
DR   HGNC; HGNC:15372; OR4F6.
DR   HPA; ENSG00000184140; Not detected.
DR   neXtProt; NX_Q8NGB9; -.
DR   PharmGKB; PA32292; -.
DR   VEuPathDB; HostDB:ENSG00000184140; -.
DR   eggNOG; ENOG502T9N1; Eukaryota.
DR   GeneTree; ENSGT00940000163199; -.
DR   HOGENOM; CLU_012526_8_2_1; -.
DR   InParanoid; Q8NGB9; -.
DR   OMA; CTQFVNY; -.
DR   OrthoDB; 1020343at2759; -.
DR   PhylomeDB; Q8NGB9; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; Q8NGB9; -.
DR   BioGRID-ORCS; 390648; 5 hits in 640 CRISPR screens.
DR   GeneWiki; OR4F6; -.
DR   GenomeRNAi; 390648; -.
DR   Pharos; Q8NGB9; Tdark.
DR   PRO; PR:Q8NGB9; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q8NGB9; protein.
DR   Bgee; ENSG00000184140; Expressed in stomach and 4 other tissues.
DR   ExpressionAtlas; Q8NGB9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 4F6"
FT                   /id="PRO_0000150548"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   312 AA;  35355 MW;  B4FE59A4354F681A CRC64;
     MDEANHSVVS EFVFLGLSDS RKIQLLLFLF FSVFYVSSLM GNLLIVLTVT SDPRLQSPMY
     FLLANLSIIN LVFCSSTAPK MIYDLFRKHK TISFGGCVVQ IFFIHAVGGT EMVLLIAMAF
     DRYVAICKPL HYLTIMNPQR CILFLVISWI IGIIHSVIQL AFVVDLLFCG PNELDSFFCD
     LPRFIKLACI ETYTLGFMVT ANSGFISLAS FLILIISYIF ILVTVQKKSS GGIFKAFSML
     SAHVIVVVLV FGPLIFFYIF PFPTSHLDKF LAIFDAVITP VLNPVIYTFR NKEMMVAMRR
     RCSQFVNYSK IF
//