ID   O4F15_HUMAN             Reviewed;         312 AA.
AC   Q8NGB8; B2RNQ5; Q6IF57; Q96R70;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   29-SEP-2021, entry version 145.
DE   RecName: Full=Olfactory receptor 4F15;
DE   AltName: Full=Olfactory receptor OR15-14;
GN   Name=OR4F15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F15";
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DR   EMBL; AB065900; BAC06116.1; -; Genomic_DNA.
DR   EMBL; CH471101; EAX02320.1; -; Genomic_DNA.
DR   EMBL; BC137064; AAI37065.1; -; mRNA.
DR   EMBL; BC137065; AAI37066.1; -; mRNA.
DR   EMBL; AF399573; AAK95058.1; -; Genomic_DNA.
DR   EMBL; BK004405; DAA04803.1; -; Genomic_DNA.
DR   CCDS; CCDS32342.1; -.
DR   RefSeq; NP_001001674.1; NM_001001674.1.
DR   SMR; Q8NGB8; -.
DR   STRING; 9606.ENSP00000333184; -.
DR   GlyGen; Q8NGB8; 1 site.
DR   BioMuta; OR4F15; -.
DR   DMDM; 38372659; -.
DR   PaxDb; Q8NGB8; -.
DR   PeptideAtlas; Q8NGB8; -.
DR   PRIDE; Q8NGB8; -.
DR   ProteomicsDB; 73468; -.
DR   Antibodypedia; 64418; 69 antibodies.
DR   DNASU; 390649; -.
DR   Ensembl; ENST00000332238; ENSP00000333184; ENSG00000182854.
DR   GeneID; 390649; -.
DR   KEGG; hsa:390649; -.
DR   UCSC; uc010uts.3; human.
DR   CTD; 390649; -.
DR   GeneCards; OR4F15; -.
DR   HGNC; HGNC:15078; OR4F15.
DR   HPA; ENSG00000182854; Tissue enhanced (blood).
DR   neXtProt; NX_Q8NGB8; -.
DR   OpenTargets; ENSG00000182854; -.
DR   PharmGKB; PA32283; -.
DR   VEuPathDB; HostDB:ENSG00000182854; -.
DR   eggNOG; ENOG502RQA5; Eukaryota.
DR   GeneTree; ENSGT00940000163067; -.
DR   InParanoid; Q8NGB8; -.
DR   OMA; MAFCSIT; -.
DR   OrthoDB; 894125at2759; -.
DR   PhylomeDB; Q8NGB8; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; Q8NGB8; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   BioGRID-ORCS; 390649; 2 hits in 611 CRISPR screens.
DR   GeneWiki; OR4F15; -.
DR   GenomeRNAi; 390649; -.
DR   Pharos; Q8NGB8; Tdark.
DR   PRO; PR:Q8NGB8; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q8NGB8; protein.
DR   Bgee; ENSG00000182854; Expressed in lung and 2 other tissues.
DR   ExpressionAtlas; Q8NGB8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 4F15"
FT                   /id="PRO_0000150549"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   312 AA;  35369 MW;  D9C37596C4302F47 CRC64;
     MNGMNHSVVS EFVFMGLTNS REIQLLLFVF SLLFYFASMM GNLVIVFTVT MDAHLHSPMY
     FLLANLSIID MAFCSITAPK MICDIFKKHK AISFRGCITQ IFFSHALGGT EMVLLIAMAF
     DRYMAICKPL HYLTIMSPRM CLYFLATSSI IGLIHSLVQL VFVVDLPFCG PNIFDSFYCD
     LPRLLRLACT NTQELEFMVT VNSGLISVGS FVLLVISYIF ILFTVWKHSS GGLAKALSTL
     SAHVTVVILF FGPLMFFYTW PSPTSHLDKY LAIFDAFITP FLNPVIYTFR NKDMKVAMRR
     LCSRLAHFTK IL
//