ID OR7G1_HUMAN Reviewed; 311 AA. AC Q8NGA0; Q6IFJ5; Q96RA1; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 16-DEC-2008, sequence version 2. DT 20-JAN-2009, entry version 52. DE RecName: Full=Olfactory receptor 7G1; DE AltName: Full=Olfactory receptor OR19-8; DE AltName: Full=Olfactory receptor 19-15; DE Short=OR19-15; GN Name=OR7G1; Synonyms=OR7G1P; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283. RX MEDLINE=22202146; PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [3] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [4] RP ERRATUM. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor (Potential). CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- SEQUENCE CAUTION: CC Sequence=BAC06141.1; Type=Erroneous gene model prediction; CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium CC (HORDE); CC URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR7G1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065926; BAC06141.1; ALT_SEQ; Genomic_DNA. DR EMBL; AF399538; AAK95023.1; -; Genomic_DNA. DR EMBL; BK004267; DAA04665.1; -; Genomic_DNA. DR UniGene; Hs.553576; -. DR PRIDE; Q8NGA0; -. DR Ensembl; ENSG00000161807; Homo sapiens. DR KEGG; hsa:125962; -. DR NMPDR; fig|9606.3.peg.15606; -. DR GeneCards; GC19M009089; -. DR H-InvDB; HIX0040170; -. DR HGNC; HGNC:8465; OR7G1. DR PharmGKB; PA32737; -. DR HOGENOM; Q8NGA0; -. DR HOVERGEN; Q8NGA0; -. DR LinkHub; Q8NGA0; -. DR NextBio; 81590; -. DR CleanEx; HS_OR7G1; -. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:InterPro. DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR11398; Olfact_rcpt; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; KW Olfaction; Polymorphism; Receptor; Sensory transduction; Transducer; KW Transmembrane. FT CHAIN 1 311 Olfactory receptor 7G1. FT /FTId=PRO_0000150650. FT TOPO_DOM 1 29 Extracellular (Potential). FT TRANSMEM 30 50 1 (Potential). FT TOPO_DOM 51 57 Cytoplasmic (Potential). FT TRANSMEM 58 78 2 (Potential). FT TOPO_DOM 79 97 Extracellular (Potential). FT TRANSMEM 98 118 3 (Potential). FT TOPO_DOM 119 133 Cytoplasmic (Potential). FT TRANSMEM 134 154 4 (Potential). FT TOPO_DOM 155 196 Extracellular (Potential). FT TRANSMEM 197 217 5 (Potential). FT TOPO_DOM 218 244 Cytoplasmic (Potential). FT TRANSMEM 245 265 6 (Potential). FT TOPO_DOM 266 269 Extracellular (Potential). FT TRANSMEM 270 290 7 (Potential). FT TOPO_DOM 291 311 Cytoplasmic (Potential). FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential). FT CARBOHYD 89 89 N-linked (GlcNAc...) (Potential). FT DISULFID 97 179 By similarity. FT VARIANT 83 83 V -> A (in dbSNP:rs6511874). FT /FTId=VAR_048074. FT VARIANT 141 141 W -> C (in dbSNP:rs2217657). FT /FTId=VAR_034255. FT VARIANT 156 156 A -> V (in dbSNP:rs7246980). FT /FTId=VAR_048075. FT VARIANT 167 167 S -> F (in dbSNP:rs7246969). FT /FTId=VAR_048076. FT VARIANT 252 252 Y -> C (in dbSNP:rs2195951). FT /FTId=VAR_034256. SQ SEQUENCE 311 AA; 34803 MW; C408FFF590A95340 CRC64; MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ ICLVLVFAGL ESCFLAVMAY DRYVAICHPL RYTVLMNVHF WGLLILLSMF MSTMDALVQS LMVLQLSFCK NVEIPLFFCE VVQVIKLACS DTLINNILIY FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST CGCHLSVFSL FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA LRKLIGRLFP F //