ID OR7G1_HUMAN Reviewed; 311 AA. AC Q8NGA0; Q6IFJ5; Q96RA1; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 16-DEC-2008, sequence version 2. DT 13-SEP-2023, entry version 159. DE RecName: Full=Olfactory receptor 7G1; DE AltName: Full=Olfactory receptor 19-15; DE Short=OR19-15; DE AltName: Full=Olfactory receptor OR19-8; GN Name=OR7G1; Synonyms=OR7G1P; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283. RX PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [4] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [5] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC06141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065926; BAC06141.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC011464; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AF399538; AAK95023.1; -; Genomic_DNA. DR EMBL; BK004267; DAA04665.1; -; Genomic_DNA. DR CCDS; CCDS32898.2; -. DR RefSeq; NP_001005192.2; NM_001005192.2. DR AlphaFoldDB; Q8NGA0; -. DR SMR; Q8NGA0; -. DR BioGRID; 125938; 1. DR IntAct; Q8NGA0; 1. DR MINT; Q8NGA0; -. DR STRING; 9606.ENSP00000444134; -. DR GlyCosmos; Q8NGA0; 2 sites, No reported glycans. DR GlyGen; Q8NGA0; 2 sites. DR BioMuta; OR7G1; -. DR DMDM; 218511731; -. DR MassIVE; Q8NGA0; -. DR PaxDb; Q8NGA0; -. DR PeptideAtlas; Q8NGA0; -. DR ProteomicsDB; 73458; -. DR Antibodypedia; 56336; 68 antibodies from 13 providers. DR DNASU; 125962; -. DR Ensembl; ENST00000541538.1; ENSP00000444134.1; ENSG00000161807.3. DR GeneID; 125962; -. DR KEGG; hsa:125962; -. DR MANE-Select; ENST00000541538.1; ENSP00000444134.1; NM_001005192.2; NP_001005192.2. DR UCSC; uc021uoi.1; human. DR AGR; HGNC:8465; -. DR CTD; 125962; -. DR GeneCards; OR7G1; -. DR HGNC; HGNC:8465; OR7G1. DR HPA; ENSG00000161807; Not detected. DR neXtProt; NX_Q8NGA0; -. DR PharmGKB; PA32737; -. DR VEuPathDB; HostDB:ENSG00000161807; -. DR eggNOG; ENOG502T9M5; Eukaryota. DR GeneTree; ENSGT00940000154619; -. DR HOGENOM; CLU_012526_1_3_1; -. DR InParanoid; Q8NGA0; -. DR OMA; QICFALT; -. DR OrthoDB; 5401587at2759; -. DR PhylomeDB; Q8NGA0; -. DR TreeFam; TF337210; -. DR PathwayCommons; Q8NGA0; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR SignaLink; Q8NGA0; -. DR BioGRID-ORCS; 125962; 7 hits in 709 CRISPR screens. DR GeneWiki; OR7G1; -. DR GenomeRNAi; 125962; -. DR Pharos; Q8NGA0; Tdark. DR PRO; PR:Q8NGA0; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q8NGA0; Protein. DR ExpressionAtlas; Q8NGA0; differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. DR CDD; cd15234; 7tmA_OR7-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48001:SF67; OLFACTORY RECEPTOR 7G1; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..311 FT /note="Olfactory receptor 7G1" FT /id="PRO_0000150650" FT TOPO_DOM 1..29 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 30..50 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 51..57 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 58..78 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 79..97 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 98..118 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 119..133 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 134..154 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 155..196 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 197..217 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 218..244 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 245..265 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 266..269 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 270..290 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 291..311 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 89 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 97..179 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 83 FT /note="V -> A (in dbSNP:rs6511874)" FT /id="VAR_048074" FT VARIANT 141 FT /note="W -> C (in dbSNP:rs2217657)" FT /id="VAR_034255" FT VARIANT 156 FT /note="A -> V (in dbSNP:rs7246980)" FT /id="VAR_048075" FT VARIANT 167 FT /note="S -> F (in dbSNP:rs7246969)" FT /id="VAR_048076" FT VARIANT 252 FT /note="Y -> C (in dbSNP:rs2195951)" FT /id="VAR_034256" SQ SEQUENCE 311 AA; 34803 MW; C408FFF590A95340 CRC64; MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ ICLVLVFAGL ESCFLAVMAY DRYVAICHPL RYTVLMNVHF WGLLILLSMF MSTMDALVQS LMVLQLSFCK NVEIPLFFCE VVQVIKLACS DTLINNILIY FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST CGCHLSVFSL FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA LRKLIGRLFP F //