ID NPB_HUMAN Reviewed; 125 AA. AC Q8NG41; A0AUX9; DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 04-DEC-2007, entry version 41. DE Neuropeptide B precursor (Preproprotein L7) (hPPL7) [Contains: DE Neuropeptide B-23 (NPB23) (hL7); Neuropeptide B-29 (NPB29) (hL7C)]. GN Name=NPB; Synonyms=PPL7, PPNPB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-48, AND SYNTHESIS RP OF NPB23. RX MEDLINE=22206627; PubMed=12118011; DOI=10.1074/jbc.M205883200; RA Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y., RA Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., RA Fujino M.; RT "Identification of a neuropeptide modified with bromine as an RT endogenous ligand for GPR7."; RL J. Biol. Chem. 277:34010-34016(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RX MEDLINE=22401788; PubMed=12401809; DOI=10.1074/jbc.M206396200; RA Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., RA Lucchetti J., Detheux M., Parmentier M.; RT "Identification of natural ligands for the orphan G protein-coupled RT receptors GPR7 and GPR8."; RL J. Biol. Chem. 278:776-783(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in the regulation of feeding, CC neuroendocrine system, memory, learning and in the afferent pain CC pathway (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Widely expressed in the central nervous CC system. High levels are found in substantia nigra, hypothalamus, CC hyppocampus, spinal cord, placenta and fetal brain; lower levels CC are found in testis, uterus and ovary. Also detected at high CC levels in colorectal adenocarcinoma. CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB085942; BAC07175.1; -; mRNA. DR EMBL; AF525737; AAP80794.1; -; mRNA. DR EMBL; AF525738; AAP80795.1; -; Other_RNA. DR EMBL; BC126128; AAI26129.1; -; mRNA. DR EMBL; BC126485; AAI26486.1; -; mRNA. DR RefSeq; NP_683694.1; -. DR RefSeq; XP_939571.1; -. DR UniGene; Hs.585089; -. DR UniGene; Hs.700354; -. DR Ensembl; ENSG00000183979; Homo sapiens. DR Ensembl; ENSG00000203773; Homo sapiens. DR GeneID; 256933; -. DR GeneID; 653419; -. DR KEGG; hsa:256933; -. DR KEGG; hsa:653419; -. DR H-InvDB; HIX0039033; -. DR H-InvDB; HIX0059771; -. DR HGNC; HGNC:30099; NPB. DR MIM; 607996; gene. DR PharmGKB; PA26397; -. DR ArrayExpress; Q8NG41; -. DR CleanEx; HS_NPB; -. DR GermOnline; ENSG00000183979; Homo sapiens. DR GO; GO:0005515; F:protein binding; IPI:HGNC. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IDA:HGNC. DR InterPro; IPR013298; Neuropept_B_pre. DR InterPro; IPR013297; Neuropept_BW_pre. DR PRINTS; PR01888; NROPEPTIDEBW. DR PRINTS; PR01889; PPNRPEPTIDEB. PE 1: Evidence at protein level; KW Cleavage on pair of basic residues; Direct protein sequencing; KW Neuropeptide; Secreted; Signal. FT SIGNAL 1 24 Potential. FT PEPTIDE 25 53 Neuropeptide B-29. FT /FTId=PRO_0000019836. FT PEPTIDE 25 48 Neuropeptide B-23. FT /FTId=PRO_0000019837. FT PROPEP 56 125 Potential. FT /FTId=PRO_0000019838. SQ SEQUENCE 125 AA; 13097 MW; 98CBFAB33B42AC90 CRC64; MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS PYARRSQPYR GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL PDGRGTYQCK ANVFLSLRAA DCLAA //