ID NPB_HUMAN Reviewed; 125 AA. AC Q8NG41; A0AUX9; A6NJD6; B9EJC3; DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 13-NOV-2019, entry version 129. DE RecName: Full=Neuropeptide B; DE AltName: Full=Preproprotein L7; DE Short=hPPL7; DE Contains: DE RecName: Full=Neuropeptide B-23; DE Short=NPB23; DE Short=hL7; DE Contains: DE RecName: Full=Neuropeptide B-29; DE Short=NPB29; DE Short=hL7C; DE Flags: Precursor; GN Name=NPB; Synonyms=PPL7, PPNPB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-48, AND SYNTHESIS RP OF NPB23. RX PubMed=12118011; DOI=10.1074/jbc.m205883200; RA Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y., RA Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., RA Fujino M.; RT "Identification of a neuropeptide modified with bromine as an RT endogenous ligand for GPR7."; RL J. Biol. Chem. 277:34010-34016(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION. RX PubMed=12401809; DOI=10.1074/jbc.m206396200; RA Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., RA Lucchetti J., Detheux M., Parmentier M.; RT "Identification of natural ligands for the orphan G protein-coupled RT receptors GPR7 and GPR8."; RL J. Biol. Chem. 278:776-783(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in the regulation of feeding, CC neuroendocrine system, memory, learning and in the afferent pain CC pathway. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Widely expressed in the central nervous CC system. High levels are found in substantia nigra, hypothalamus, CC hyppocampus, spinal cord, placenta and fetal brain; lower levels CC are found in testis, uterus and ovary. Also detected at high CC levels in colorectal adenocarcinoma. CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB085942; BAC07175.1; -; mRNA. DR EMBL; AF525737; AAP80794.1; -; mRNA. DR EMBL; AF525738; AAP80795.1; -; Transcribed_RNA. DR EMBL; AL360181; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC126128; AAI26129.1; -; mRNA. DR EMBL; BC126485; AAI26486.1; -; mRNA. DR EMBL; BC146875; AAI46876.1; -; mRNA. DR EMBL; BC146890; AAI46891.1; -; mRNA. DR CCDS; CCDS11790.1; -. DR RefSeq; NP_683694.1; NM_148896.4. DR BioGrid; 129184; 28. DR IntAct; Q8NG41; 26. DR STRING; 9606.ENSP00000332766; -. DR iPTMnet; Q8NG41; -. DR PhosphoSitePlus; Q8NG41; -. DR BioMuta; NPB; -. DR jPOST; Q8NG41; -. DR MassIVE; Q8NG41; -. DR PaxDb; Q8NG41; -. DR PeptideAtlas; Q8NG41; -. DR PRIDE; Q8NG41; -. DR ProteomicsDB; 73419; -. DR Ensembl; ENST00000333383; ENSP00000332766; ENSG00000183979. DR GeneID; 256933; -. DR KEGG; hsa:256933; -. DR UCSC; uc002kcd.4; human. DR CTD; 256933; -. DR DisGeNET; 256933; -. DR GeneCards; NPB; -. DR HGNC; HGNC:30099; NPB. DR MIM; 607996; gene. DR neXtProt; NX_Q8NG41; -. DR OpenTargets; ENSG00000183979; -. DR PharmGKB; PA142671255; -. DR eggNOG; ENOG410J07G; Eukaryota. DR eggNOG; ENOG41120QH; LUCA. DR GeneTree; ENSGT00940000158204; -. DR HOGENOM; HOG000231239; -. DR InParanoid; Q8NG41; -. DR KO; K05267; -. DR OrthoDB; 871204at2759; -. DR PhylomeDB; Q8NG41; -. DR TreeFam; TF333179; -. DR Reactome; R-HSA-375276; Peptide ligand-binding receptors. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR GenomeRNAi; 256933; -. DR Pharos; Q8NG41; -. DR PRO; PR:Q8NG41; -. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000183979; Expressed in 85 organ(s), highest expression level in C1 segment of cervical spinal cord. DR ExpressionAtlas; Q8NG41; baseline and differential. DR Genevisible; Q8NG41; HS. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:HGNC-UCL. DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW. DR InterPro; IPR013298; Neuropept_B_pre. DR InterPro; IPR013297; Neuropept_BW_pre. DR PANTHER; PTHR28553; PTHR28553; 1. DR Pfam; PF15180; NPBW; 1. DR PRINTS; PR01888; NROPEPTIDEBW. DR PRINTS; PR01889; PPNRPEPTIDEB. PE 1: Evidence at protein level; KW Cleavage on pair of basic residues; Complete proteome; KW Direct protein sequencing; Neuropeptide; Reference proteome; Secreted; KW Signal. FT SIGNAL 1 24 {ECO:0000255}. FT PEPTIDE 25 53 Neuropeptide B-29. FT /FTId=PRO_0000019836. FT PEPTIDE 25 48 Neuropeptide B-23. FT /FTId=PRO_0000019837. FT PROPEP 56 125 {ECO:0000255}. FT /FTId=PRO_0000019838. SQ SEQUENCE 125 AA; 13097 MW; 98CBFAB33B42AC90 CRC64; MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS PYARRSQPYR GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL PDGRGTYQCK ANVFLSLRAA DCLAA //