ID NPB_HUMAN STANDARD; PRT; 125 AA. AC Q8NG41; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Neuropeptide B precursor (Preproprotein L7) (hPPL7) [Contains: DE Neuropeptide B-23 (NPB23) (hL7); Neuropeptide B-29 (NPB29) (hL7C)]. GN NPB OR PPNPB OR PPL7. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., SEQUENCE OF 25-48, AND SYNTHESIS OF NPB23. RX MEDLINE=22206627; PubMed=12118011; DOI=10.1074/jbc.M205883200; RA Fujii R., Yoshida H., Fukusumi S., Habata Y., Hosoya M., Kawamata Y., RA Yano T., Hinuma S., Kitada C., Asami T., Mori M., Fujisawa Y., RA Fujino M.; RT "Identification of a neuropeptide modified with bromine as an RT endogenous ligand for GPR7."; RL J. Biol. Chem. 277:34010-34016(2002). RN [2] RP SEQUENCE FROM N.A., AND CHARACTERIZATION. RX MEDLINE=22401788; PubMed=12401809; DOI=10.1074/jbc.M206396200; RA Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., RA Lucchetti J., Detheux M., Parmentier M.; RT "Identification of natural ligands for the orphan G protein-coupled RT receptors GPR7 and GPR8."; RL J. Biol. Chem. 278:776-783(2003). CC -!- FUNCTION: May be involved in the regulation of feeding, CC neuroendocrine system, memory, learning and in the afferent pain CC pathway (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Widely expressed in the central nervous CC system. High levels are found in substantia nigra, hypothalamus, CC hyppocampus, spinal cord, placenta and fetal brain; lower levels CC are found in testis, uterus and ovary. Also detected at high CC levels in colorectal adenocarcinoma. CC -!- SIMILARITY: Belongs to the neuropeptide B/W family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB085942; BAC07175.1; -. DR EMBL; AF525737; AAP80794.1; -. DR EMBL; AF525738; AAP80795.1; -. DR MIM; 607996; -. KW Neuropeptide; Signal; Cleavage on pair of basic residues; KW Direct protein sequencing. FT SIGNAL 1 24 Potential. FT PEPTIDE 25 48 Neuropeptide B-23. FT PEPTIDE 25 53 Neuropeptide B-29. FT PROPEP 56 125 Potential. SQ SEQUENCE 125 AA; 13097 MW; 98CBFAB33B42AC90 CRC64; MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS PYARRSQPYR GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL PDGRGTYQCK ANVFLSLRAA DCLAA //