ID TT21A_HUMAN Reviewed; 1320 AA. AC Q8NDW8; A1L388; B4DYF6; B4DYJ3; D3YTE7; D4PHA5; Q6P5W8; Q8N7G5; AC Q8NA02; DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 3. DT 07-JUN-2017, entry version 122. DE RecName: Full=Tetratricopeptide repeat protein 21A; DE Short=TPR repeat protein 21A; DE AltName: Full=Stress-inducible protein 2; GN Name=TTC21A; Synonyms=STI2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND RP VARIANT LYS-1316. RC TISSUE=Pancreas; RX PubMed=12543795; RA Protopopov A., Kashuba V., Zabarovska V.I., Muravenko O.V., RA Lerman M.I., Klein G., Zabarovsky E.R.; RT "An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 RT (AP20) region implicated in major human epithelial malignancies."; RL Cancer Res. 63:404-412(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE RP SCALE MRNA] OF 440-1320 (ISOFORMS 5/6/7), AND VARIANT LEU-1055. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=Q8NDW8-1; Sequence=Displayed; CC Name=3; CC IsoId=Q8NDW8-3; Sequence=VSP_026297; CC Note=No experimental confirmation available.; CC Name=5; CC IsoId=Q8NDW8-5; Sequence=VSP_038429, VSP_038430, VSP_038431; CC Note=No experimental confirmation available.; CC Name=6; CC IsoId=Q8NDW8-6; Sequence=VSP_038428, VSP_038429, VSP_038431; CC Note=No experimental confirmation available.; CC Name=7; CC IsoId=Q8NDW8-7; Sequence=VSP_038431; CC Note=No experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Strongly expressed in testis. CC {ECO:0000269|PubMed:12543795}. CC -!- SIMILARITY: Belongs to the TTC21 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC04129.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ487015; CAD31647.1; -; mRNA. DR EMBL; AK093313; BAC04129.1; ALT_INIT; mRNA. DR EMBL; AK098528; BAC05323.1; -; mRNA. DR EMBL; AK302408; BAG63718.1; -; mRNA. DR EMBL; AK302465; BAG63755.1; -; mRNA. DR EMBL; AC092053; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC138124; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS43068.2; -. [Q8NDW8-6] DR CCDS; CCDS46800.1; -. [Q8NDW8-1] DR RefSeq; NP_001098983.2; NM_001105513.2. [Q8NDW8-6] DR RefSeq; NP_665698.2; NM_145755.2. [Q8NDW8-1] DR UniGene; Hs.443935; -. DR ProteinModelPortal; Q8NDW8; -. DR BioGrid; 128260; 3. DR IntAct; Q8NDW8; 3. DR STRING; 9606.ENSP00000398211; -. DR iPTMnet; Q8NDW8; -. DR PhosphoSitePlus; Q8NDW8; -. DR BioMuta; TTC21A; -. DR DMDM; 296453007; -. DR PaxDb; Q8NDW8; -. DR PeptideAtlas; Q8NDW8; -. DR PRIDE; Q8NDW8; -. DR TopDownProteomics; Q8NDW8-6; -. [Q8NDW8-6] DR Ensembl; ENST00000431162; ENSP00000398211; ENSG00000168026. [Q8NDW8-1] DR Ensembl; ENST00000440121; ENSP00000410882; ENSG00000168026. [Q8NDW8-6] DR GeneID; 199223; -. DR KEGG; hsa:199223; -. DR UCSC; uc003cjc.3; human. [Q8NDW8-1] DR CTD; 199223; -. DR DisGeNET; 199223; -. DR GeneCards; MIR6822; -. DR GeneCards; TTC21A; -. DR HGNC; HGNC:30761; TTC21A. DR HPA; HPA035510; -. DR HPA; HPA035511; -. DR MIM; 611430; gene. DR neXtProt; NX_Q8NDW8; -. DR OpenTargets; ENSG00000168026; -. DR PharmGKB; PA134915959; -. DR eggNOG; ENOG410IEX1; Eukaryota. DR eggNOG; ENOG410XV69; LUCA. DR GeneTree; ENSGT00390000005979; -. DR HOVERGEN; HBG108607; -. DR InParanoid; Q8NDW8; -. DR OMA; MNDVKCL; -. DR OrthoDB; EOG091G00TY; -. DR PhylomeDB; Q8NDW8; -. DR TreeFam; TF314664; -. DR ChiTaRS; TTC21A; human. DR GenomeRNAi; 199223; -. DR PRO; PR:Q8NDW8; -. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000168026; -. DR CleanEx; HS_TTC21A; -. DR ExpressionAtlas; Q8NDW8; baseline and differential. DR Genevisible; Q8NDW8; HS. DR Gene3D; 1.25.40.10; -; 10. DR InterPro; IPR013026; TPR-contain_dom. DR InterPro; IPR011990; TPR-like_helical_dom. DR InterPro; IPR019734; TPR_repeat. DR Pfam; PF13181; TPR_8; 1. DR SMART; SM00028; TPR; 13. DR SUPFAM; SSF48452; SSF48452; 6. DR PROSITE; PS50005; TPR; 9. DR PROSITE; PS50293; TPR_REGION; 4. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Polymorphism; KW Reference proteome; Repeat; TPR repeat. FT CHAIN 1 1320 Tetratricopeptide repeat protein 21A. FT /FTId=PRO_0000291915. FT REPEAT 4 38 TPR 1. FT REPEAT 110 143 TPR 2. FT REPEAT 146 180 TPR 3. FT REPEAT 181 213 TPR 4. FT REPEAT 215 247 TPR 5. FT REPEAT 334 367 TPR 6. FT REPEAT 502 534 TPR 7. FT REPEAT 572 605 TPR 8. FT REPEAT 728 761 TPR 9. FT REPEAT 762 795 TPR 10. FT REPEAT 797 828 TPR 11. FT REPEAT 837 869 TPR 12. FT REPEAT 889 922 TPR 13. FT REPEAT 924 956 TPR 14. FT REPEAT 957 990 TPR 15. FT REPEAT 1028 1061 TPR 16. FT REPEAT 1201 1234 TPR 17. FT REPEAT 1236 1268 TPR 18. FT REPEAT 1270 1303 TPR 19. FT VAR_SEQ 1 879 Missing (in isoform 3). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_026297. FT VAR_SEQ 147 187 Missing (in isoform 6). {ECO:0000305}. FT /FTId=VSP_038428. FT VAR_SEQ 268 275 Missing (in isoform 5 and isoform 6). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_038429. FT VAR_SEQ 386 396 Missing (in isoform 5). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_038430. FT VAR_SEQ 515 515 S -> SG (in isoform 5, isoform 6 and FT isoform 7). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_038431. FT VARIANT 91 91 R -> Q (in dbSNP:rs1112438). FT /FTId=VAR_032879. FT VARIANT 108 108 V -> L (in dbSNP:rs17855763). FT /FTId=VAR_032880. FT VARIANT 290 290 R -> K (in dbSNP:rs1274972). FT /FTId=VAR_032881. FT VARIANT 293 293 E -> K (in dbSNP:rs1274971). FT /FTId=VAR_032882. FT VARIANT 622 622 R -> W (in dbSNP:rs35581078). FT /FTId=VAR_032883. FT VARIANT 719 719 R -> H (in dbSNP:rs9861353). FT /FTId=VAR_059861. FT VARIANT 719 719 R -> Q (in dbSNP:rs9861353). FT /FTId=VAR_032884. FT VARIANT 1055 1055 R -> L (in dbSNP:rs35934336). FT {ECO:0000269|PubMed:14702039}. FT /FTId=VAR_032885. FT VARIANT 1160 1160 S -> R (in dbSNP:rs34201693). FT /FTId=VAR_032886. FT VARIANT 1316 1316 R -> K (in dbSNP:rs704959). FT {ECO:0000269|PubMed:12543795}. FT /FTId=VAR_032887. FT CONFLICT 153 153 V -> G (in Ref. 1; CAD31647). FT {ECO:0000305}. FT CONFLICT 174 174 I -> T (in Ref. 2; BAG63718). FT {ECO:0000305}. FT CONFLICT 802 802 G -> D (in Ref. 2; BAG63755). FT {ECO:0000305}. FT CONFLICT 803 803 K -> E (in Ref. 1; CAD31647). FT {ECO:0000305}. FT CONFLICT 838 838 K -> R (in Ref. 2; BAG63718). FT {ECO:0000305}. FT CONFLICT 1095 1095 M -> T (in Ref. 1; CAD31647). FT {ECO:0000305}. FT CONFLICT 1165 1165 L -> P (in Ref. 2; BAC04129). FT {ECO:0000305}. FT CONFLICT 1291 1291 E -> K (in Ref. 2; BAG63755). FT {ECO:0000305}. SQ SEQUENCE 1320 AA; 150944 MW; CFB949A8E2B702DE CRC64; MSSNDSSLMA GIIYYSQEKY FHHVQQAAAV GLEKFSNDPV LKFFKAYGVL KEEHIQDAIS DLESIRHHPD VSLCSTMALI YAHKRCEIID REAIQELEYS LKEIRKTVSG TALYYAGLFL WLIGRHDKAK EYIDRMLKIS RGFREAYVLR GWVDLTSDKP HTAKKAIEYL EQGIQDTKDV LGLMGKAMYF MMQQNYSEAL EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVEMGHRI LEKDESNIDA CQILTVHELA REGNMTTVSS LKTQKATNHV RNLIKALETR EPENPSLHLK KIIVVSRLCG SHQVILGLVC SFIERTFMAT PSYVHVATEL GYLFILKNQV KEALLWYSEA MKLDKDGMAG LTGIILCHIL EGHLEEAEYR LEFLKEVQKS LGKSEVLIFL QALLMSRKHK GEEETTALLK EAVELHFSSM QGIPLGSEYF EKLDPYFLVC IAKEYLLFCP KQPRLPGQIV SPLLKQVAVI LNPVVKAAPA LIDPLYLMAQ VRYYSELENA QSILQRCLEL DPASVDAHLL MCQIYLAQGN FGMCFHCLEL GVSHNFQVRD HPLYHLIKAR ALNKAGDYPE AIKTLKMVIK LPALKKEEGR KFLRPSVQPS QRASILLELV EALRLNGELH EATKVMQDTI NEFGGTPEEN RITIANVDLV LSKGNVDVAL NMLRNILPKQ SCYMEAREKM ANIYLQTLRD RRLYIRCYRE LCEHLPGPHT SLLLGDALMS ILEPEKALEV YDEAYRQNPH DASLASRIGH AYVKAHQYTE AIEYYEAAQK INGQDFLCCD LGKLLLKLKK VNKAEKVLKQ ALEHDIVQDI PSMMNDVKCL LLLAKVYKSH KKEAVIETLN KALDLQSRIL KRVPLEQPEM IPSQKQLAAS ICIQFAEHYL AEKEYDKAVQ SYKDVFSYLP TDNKVMLELA QLYLLQGHLD LCEQHCAILL QTEQNHETAS VLMADLMFRK QKHEAAINLY HQVLEKAPDN FLVLHKLIDL LRRSGKLEDI PAFFELAKKV SSRVPLEPGF NYCRGIYCWH IGQPNEALKF LNKARKDSTW GQSAIYHMVQ ICLNPDNEVV GGEAFENQGA ESNYMEKKEL EQQGVSTAEK LLREFYPHSD SSQTQLRLLQ GLCRLATREK ANMEAALGSF IQIAQAEKDS VPALLALAQA YVFLKQIPKA RMQLKRLAKT PWVLSEAEDL EKSWLLLADI YCQGSKFDLA LELLRRCVQY NKSCYKAYEY MGFIMEKEQS YKDAVTNYKL AWKYSHHANP AIGFKLAFNY LKDKKFVEAI EICNDVLREH PDYPKIREEI LEKARRSLRP //