ID CC150_HUMAN Reviewed; 1101 AA. AC Q8NCX0; Q6P5U6; Q6P663; Q8N8V5; DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 08-APR-2008, sequence version 2. DT 01-SEP-2009, entry version 34. DE RecName: Full=Coiled-coil domain-containing protein 150; GN Name=CCDC150; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Liver; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE RP SEQUENCE [LARGE SCALE MRNA] OF 1-888 (ISOFORM 2). RC TISSUE=Kidney, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q8NCX0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NCX0-2; Sequence=VSP_032873, VSP_032874, VSP_032877, CC VSP_032878; CC Name=3; CC IsoId=Q8NCX0-3; Sequence=VSP_032872, VSP_032877, VSP_032878; CC Name=4; CC IsoId=Q8NCX0-4; Sequence=VSP_032872, VSP_032875, VSP_032876; CC -!- SEQUENCE CAUTION: CC Sequence=AAH62658.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK096130; BAC04706.1; -; mRNA. DR EMBL; AL834537; CAD39193.1; -; mRNA. DR EMBL; AC068544; AAY14905.1; -; Genomic_DNA. DR EMBL; CH471063; EAW70131.1; -; Genomic_DNA. DR EMBL; BC062449; AAH62449.1; -; mRNA. DR EMBL; BC062658; AAH62658.1; ALT_SEQ; mRNA. DR IPI; IPI00301743; -. DR IPI; IPI00783185; -. DR IPI; IPI00889736; -. DR IPI; IPI00889749; -. DR RefSeq; NP_001074008.1; -. DR UniGene; Hs.132519; -. DR PRIDE; Q8NCX0; -. DR Ensembl; ENST00000272832; ENSP00000272832; ENSG00000144395; Homo sapiens. DR Ensembl; ENST00000389175; ENSP00000373827; ENSG00000144395; Homo sapiens. DR Ensembl; ENST00000409742; ENSP00000387192; ENSG00000144395; Homo sapiens. DR GeneID; 284992; -. DR KEGG; hsa:284992; -. DR UCSC; uc002utp.1; human. DR UCSC; uc002utq.1; human. DR UCSC; uc002utr.1; human. DR CTD; 284992; -. DR GeneCards; GC02P197214; -. DR HGNC; HGNC:26834; CCDC150. DR HOVERGEN; Q8NCX0; -. DR NextBio; 95202; -. DR ArrayExpress; Q8NCX0; -. DR Bgee; Q8NCX0; -. DR CleanEx; HS_CCDC150; -. PE 2: Evidence at transcript level; KW Alternative splicing; Coiled coil; Complete proteome; Polymorphism. FT CHAIN 1 1101 Coiled-coil domain-containing protein FT 150. FT /FTId=PRO_0000328984. FT COILED 106 299 Potential. FT COILED 398 680 Potential. FT COILED 712 940 Potential. FT COILED 970 1033 Potential. FT VAR_SEQ 1 685 Missing (in isoform 3 and isoform 4). FT /FTId=VSP_032872. FT VAR_SEQ 1 513 Missing (in isoform 2). FT /FTId=VSP_032873. FT VAR_SEQ 514 622 QTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESK FT NKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYL FT QTKYAQANSELSAKRVHLQQADAHLKE -> MPLRKRKSPE FT RTASSKSPEISRSHVNSIKERTSSVGLPSVIPNSTRRVSFA FT PNLPSMKTSQDIGDSRISLKTLLNAIKTMEGRLEGKIEILA FT SRPLINDESPNFLKQDS (in isoform 2). FT /FTId=VSP_032874. FT VAR_SEQ 853 853 L -> V (in isoform 4). FT /FTId=VSP_032875. FT VAR_SEQ 854 1101 Missing (in isoform 4). FT /FTId=VSP_032876. FT VAR_SEQ 918 930 QIEKELKQMELIK -> VVWETSSHFLDTL (in FT isoform 2 and isoform 3). FT /FTId=VSP_032877. FT VAR_SEQ 931 1101 Missing (in isoform 2 and isoform 3). FT /FTId=VSP_032878. FT VARIANT 156 156 E -> K (in dbSNP:rs34133636). FT /FTId=VAR_042600. FT CONFLICT 746 746 M -> V (in Ref. 5; AAH62658). FT CONFLICT 841 841 T -> A (in Ref. 5; AAH62658). SQ SEQUENCE 1101 AA; 128761 MW; 1D22BFF73725E588 CRC64; MDCKVHMETT VSRPVLSPTH INATASETFT VLQQRMRIVE EQTSSLRDDL IMLDFGEKRG YLEAPDCLED LDSQKVISPI QNEAICAGKT DILWKNCEFL VNRMCRLESL MQSLKMNIFR LQTEKDLNPQ KTAFLKDRLN AIQEEHSKDL KLLHLEVMNL RQQLRAVKEE EDKAQDEVQR LTATLKIASQ TKKNAAIIEE ELKTTKRKMN LKIQELRRQL AQEKYLRESL EKSASAMLLK IQEMGSTVEV ERKQVHILQQ NCIALRDSIQ SAQELLAQEQ KKKEELEIAT SQLKSDLTSR DDLISKLVEE NKNLQISFNK EHEENAYLRS EIMSLHEASE KAQVLNDQLT KKCSELSCML QTVTMEKARI IADHQAILQV EQKMMTQTFQ EQNLLLDAAH ASITNELQTV QNEKTQLQAH LDHLILEHNQ CIQKAQDAEK RTAVQKELLE STIARLRGEL EASMQEKKSL LEEKERFQRE VNKTEKEIVQ ERCNLEKELA KNKVDINTLT HNLQTLEEEN KHLADQMASL ELQQVTSDYH GLAQQKVEKI TESKNKLAYE NGKLQIKVKQ LEEQVQSFTD TSLQNDHLRK MNKYLQTKYA QANSELSAKR VHLQQADAHL KEVKSILERS KEELSRTVKC RNAALKESQK LKEDLEAVED RENKKVGNFQ RQLAEAKEDN CKVTIMLENV LASHSKMQGA LEKVQIELGR RDSEIAGLKK ERDLNQQRVQ KLEAEVDQWQ ARMLVMEDQH NSEIESLQKA LGVAREDNRK LAMSLEQALQ TNNHLQTKLD HIQEQLESKE LERQNLETFK DRMTEESKVE AELHAERIEA LRKQFQTERE TTKKVAQREV AELKKALDEA NFRSVEVSRT NRELRQKLAE LEKILESNKE KIKNQKTQIK LHLSAKANNA QNIERMKQIE KELKQMELIK DQYQKKNYEQ SLSIQRFVCE MTNLQKEMQM LAKSQYDASV RNKQQELHLE AERKIRQELE NRCQELEETV RHLKKCKEAT ENTLKEASVE SEQITANLEE AHRWFKHRFD GLQLELTKNR LQRPSGEDRW QEKDQDVKHD VMSNQSVLHR WERKQNLRPM PKKYHSEVQR K //