ID CC150_HUMAN Reviewed; 1101 AA. AC Q8NCX0; Q6P5U6; Q6P663; Q8N8V5; DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 08-APR-2008, sequence version 2. DT 07-OCT-2020, entry version 107. DE RecName: Full=Coiled-coil domain-containing protein 150; GN Name=CCDC150; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Liver; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 1-888 (ISOFORM 2). RC TISSUE=Kidney, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q8NCX0; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10269342, EBI-618309; CC Q8NCX0; P37198: NUP62; NbExp=3; IntAct=EBI-10269342, EBI-347978; CC Q8NCX0-3; Q96JC9: EAF1; NbExp=3; IntAct=EBI-12235840, EBI-769261; CC Q8NCX0-3; Q08379: GOLGA2; NbExp=3; IntAct=EBI-12235840, EBI-618309; CC Q8NCX0-3; P61970: NUTF2; NbExp=3; IntAct=EBI-12235840, EBI-591778; CC Q8NCX0-3; Q99633: PRPF18; NbExp=3; IntAct=EBI-12235840, EBI-2798416; CC Q8NCX0-3; P28074: PSMB5; NbExp=3; IntAct=EBI-12235840, EBI-357828; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q8NCX0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NCX0-2; Sequence=VSP_032873, VSP_032874, VSP_032877, CC VSP_032878; CC Name=3; CC IsoId=Q8NCX0-3; Sequence=VSP_032872, VSP_032877, VSP_032878; CC Name=4; CC IsoId=Q8NCX0-4; Sequence=VSP_032872, VSP_032875, VSP_032876; CC -!- SEQUENCE CAUTION: CC Sequence=AAH62658.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK096130; BAC04706.1; -; mRNA. DR EMBL; AL834537; CAD39193.1; -; mRNA. DR EMBL; AC068544; AAY14905.1; -; Genomic_DNA. DR EMBL; CH471063; EAW70131.1; -; Genomic_DNA. DR EMBL; BC062449; AAH62449.1; -; mRNA. DR EMBL; BC062658; AAH62658.1; ALT_SEQ; mRNA. DR CCDS; CCDS46478.1; -. [Q8NCX0-1] DR RefSeq; NP_001074008.1; NM_001080539.1. [Q8NCX0-1] DR SMR; Q8NCX0; -. DR BioGRID; 129990; 10. DR IntAct; Q8NCX0; 7. DR STRING; 9606.ENSP00000373827; -. DR CarbonylDB; Q8NCX0; -. DR iPTMnet; Q8NCX0; -. DR PhosphoSitePlus; Q8NCX0; -. DR BioMuta; CCDC150; -. DR DMDM; 182705170; -. DR EPD; Q8NCX0; -. DR jPOST; Q8NCX0; -. DR MassIVE; Q8NCX0; -. DR PaxDb; Q8NCX0; -. DR PeptideAtlas; Q8NCX0; -. DR PRIDE; Q8NCX0; -. DR ProteomicsDB; 72962; -. [Q8NCX0-1] DR ProteomicsDB; 72963; -. [Q8NCX0-2] DR ProteomicsDB; 72964; -. [Q8NCX0-3] DR ProteomicsDB; 72965; -. [Q8NCX0-4] DR Antibodypedia; 67231; 28 antibodies. DR DNASU; 284992; -. DR Ensembl; ENST00000389175; ENSP00000373827; ENSG00000144395. [Q8NCX0-1] DR Ensembl; ENST00000448409; ENSP00000413957; ENSG00000144395. [Q8NCX0-2] DR GeneID; 284992; -. DR KEGG; hsa:284992; -. DR UCSC; uc002utp.1; human. [Q8NCX0-1] DR CTD; 284992; -. DR EuPathDB; HostDB:ENSG00000144395.17; -. DR GeneCards; CCDC150; -. DR HGNC; HGNC:26834; CCDC150. DR HPA; ENSG00000144395; Tissue enhanced (kidney, testis). DR neXtProt; NX_Q8NCX0; -. DR OpenTargets; ENSG00000144395; -. DR PharmGKB; PA162381583; -. DR eggNOG; ENOG502QRGC; Eukaryota. DR GeneTree; ENSGT00390000005285; -. DR HOGENOM; CLU_004802_0_0_1; -. DR InParanoid; Q8NCX0; -. DR OMA; AQEKCNL; -. DR OrthoDB; 624497at2759; -. DR PhylomeDB; Q8NCX0; -. DR TreeFam; TF338017; -. DR PathwayCommons; Q8NCX0; -. DR BioGRID-ORCS; 284992; 3 hits in 877 CRISPR screens. DR ChiTaRS; CCDC150; human. DR GenomeRNAi; 284992; -. DR Pharos; Q8NCX0; Tdark. DR PRO; PR:Q8NCX0; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q8NCX0; protein. DR Bgee; ENSG00000144395; Expressed in testis and 123 other tissues. DR ExpressionAtlas; Q8NCX0; baseline and differential. DR Genevisible; Q8NCX0; HS. DR InterPro; IPR038807; CCDC150. DR PANTHER; PTHR35352; PTHR35352; 2. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Polymorphism; Reference proteome. FT CHAIN 1..1101 FT /note="Coiled-coil domain-containing protein 150" FT /id="PRO_0000328984" FT COILED 106..299 FT /evidence="ECO:0000255" FT COILED 398..680 FT /evidence="ECO:0000255" FT COILED 712..940 FT /evidence="ECO:0000255" FT COILED 970..1033 FT /evidence="ECO:0000255" FT VAR_SEQ 1..685 FT /note="Missing (in isoform 3 and isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_032872" FT VAR_SEQ 1..513 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:17974005" FT /id="VSP_032873" FT VAR_SEQ 514..622 FT /note="QTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQ FT IKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKE FT -> MPLRKRKSPERTASSKSPEISRSHVNSIKERTSSVGLPSVIPNSTRRVSFAPNLPS FT MKTSQDIGDSRISLKTLLNAIKTMEGRLEGKIEILASRPLINDESPNFLKQDS (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:17974005" FT /id="VSP_032874" FT VAR_SEQ 853 FT /note="L -> V (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_032875" FT VAR_SEQ 854..1101 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_032876" FT VAR_SEQ 918..930 FT /note="QIEKELKQMELIK -> VVWETSSHFLDTL (in isoform 2 and FT isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:17974005" FT /id="VSP_032877" FT VAR_SEQ 931..1101 FT /note="Missing (in isoform 2 and isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:17974005" FT /id="VSP_032878" FT VARIANT 156 FT /note="E -> K (in dbSNP:rs34133636)" FT /id="VAR_042600" FT CONFLICT 746 FT /note="M -> V (in Ref. 5; AAH62658)" FT /evidence="ECO:0000305" FT CONFLICT 841 FT /note="T -> A (in Ref. 5; AAH62658)" FT /evidence="ECO:0000305" SQ SEQUENCE 1101 AA; 128761 MW; 1D22BFF73725E588 CRC64; MDCKVHMETT VSRPVLSPTH INATASETFT VLQQRMRIVE EQTSSLRDDL IMLDFGEKRG YLEAPDCLED LDSQKVISPI QNEAICAGKT DILWKNCEFL VNRMCRLESL MQSLKMNIFR LQTEKDLNPQ KTAFLKDRLN AIQEEHSKDL KLLHLEVMNL RQQLRAVKEE EDKAQDEVQR LTATLKIASQ TKKNAAIIEE ELKTTKRKMN LKIQELRRQL AQEKYLRESL EKSASAMLLK IQEMGSTVEV ERKQVHILQQ NCIALRDSIQ SAQELLAQEQ KKKEELEIAT SQLKSDLTSR DDLISKLVEE NKNLQISFNK EHEENAYLRS EIMSLHEASE KAQVLNDQLT KKCSELSCML QTVTMEKARI IADHQAILQV EQKMMTQTFQ EQNLLLDAAH ASITNELQTV QNEKTQLQAH LDHLILEHNQ CIQKAQDAEK RTAVQKELLE STIARLRGEL EASMQEKKSL LEEKERFQRE VNKTEKEIVQ ERCNLEKELA KNKVDINTLT HNLQTLEEEN KHLADQMASL ELQQVTSDYH GLAQQKVEKI TESKNKLAYE NGKLQIKVKQ LEEQVQSFTD TSLQNDHLRK MNKYLQTKYA QANSELSAKR VHLQQADAHL KEVKSILERS KEELSRTVKC RNAALKESQK LKEDLEAVED RENKKVGNFQ RQLAEAKEDN CKVTIMLENV LASHSKMQGA LEKVQIELGR RDSEIAGLKK ERDLNQQRVQ KLEAEVDQWQ ARMLVMEDQH NSEIESLQKA LGVAREDNRK LAMSLEQALQ TNNHLQTKLD HIQEQLESKE LERQNLETFK DRMTEESKVE AELHAERIEA LRKQFQTERE TTKKVAQREV AELKKALDEA NFRSVEVSRT NRELRQKLAE LEKILESNKE KIKNQKTQIK LHLSAKANNA QNIERMKQIE KELKQMELIK DQYQKKNYEQ SLSIQRFVCE MTNLQKEMQM LAKSQYDASV RNKQQELHLE AERKIRQELE NRCQELEETV RHLKKCKEAT ENTLKEASVE SEQITANLEE AHRWFKHRFD GLQLELTKNR LQRPSGEDRW QEKDQDVKHD VMSNQSVLHR WERKQNLRPM PKKYHSEVQR K //