ID   NKAI3_HUMAN             Reviewed;         197 AA.
AC   Q8N8D7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   12-APR-2017, entry version 97.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3;
DE            Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3;
DE   AltName: Full=Protein FAM77D;
GN   Name=NKAIN3; Synonyms=FAM77D;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SUBUNIT: Interacts with ATP1B1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}.
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DR   EMBL; AK096949; BAC04909.1; -; mRNA.
DR   UniGene; Hs.654662; -.
DR   SMR; Q8N8D7; -.
DR   STRING; 9606.ENSP00000333627; -.
DR   TCDB; 8.B.27.1.4; the na+k+-atpase beta-subunit interacting nkain (nkain) family.
DR   PhosphoSitePlus; Q8N8D7; -.
DR   BioMuta; NKAIN3; -.
DR   DMDM; 74729419; -.
DR   PaxDb; Q8N8D7; -.
DR   PeptideAtlas; Q8N8D7; -.
DR   PRIDE; Q8N8D7; -.
DR   DNASU; 286183; -.
DR   Ensembl; ENST00000523211; ENSP00000429073; ENSG00000185942.
DR   UCSC; uc010lyq.2; human.
DR   DisGeNET; 286183; -.
DR   GeneCards; NKAIN3; -.
DR   HGNC; HGNC:26829; NKAIN3.
DR   HPA; HPA018833; -.
DR   MIM; 612872; gene.
DR   neXtProt; NX_Q8N8D7; -.
DR   OpenTargets; ENSG00000185942; -.
DR   PharmGKB; PA162397582; -.
DR   eggNOG; KOG4556; Eukaryota.
DR   eggNOG; ENOG410XS8X; LUCA.
DR   GeneTree; ENSGT00390000013699; -.
DR   HOGENOM; HOG000293382; -.
DR   HOVERGEN; HBG108190; -.
DR   InParanoid; Q8N8D7; -.
DR   OMA; PGCIRRV; -.
DR   OrthoDB; EOG091G0X6F; -.
DR   PhylomeDB; Q8N8D7; -.
DR   TreeFam; TF321348; -.
DR   ChiTaRS; NKAIN3; human.
DR   PRO; PR:Q8N8D7; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000185942; -.
DR   CleanEx; HS_NKAIN3; -.
DR   ExpressionAtlas; Q8N8D7; baseline and differential.
DR   Genevisible; Q8N8D7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central.
DR   InterPro; IPR008516; Na/K-Atpase_Interacting.
DR   PANTHER; PTHR13084; PTHR13084; 1.
DR   Pfam; PF05640; NKAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Membrane; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    197       Sodium/potassium-transporting ATPase
FT                                subunit beta-1-interacting protein 3.
FT                                /FTId=PRO_0000263093.
FT   TRANSMEM      2     22       Helical. {ECO:0000255}.
FT   TRANSMEM     35     55       Helical. {ECO:0000255}.
FT   TRANSMEM     62     82       Helical. {ECO:0000255}.
FT   TRANSMEM    152    172       Helical. {ECO:0000255}.
FT   VARIANT     140    140       V -> I (in dbSNP:rs4739003).
FT                                /FTId=VAR_029583.
SQ   SEQUENCE   197 AA;  22620 MW;  1891A3188A9296DC CRC64;
     MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR
     YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP
     PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC
     DLQVCKHLFI QMLQIIE
//