ID NKAI3_HUMAN Reviewed; 197 AA. AC Q8N8D7; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 24-JAN-2024, entry version 127. DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; DE Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3; DE AltName: Full=Protein FAM77D; GN Name=NKAIN3; Synonyms=FAM77D; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Small intestine; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). CC -!- SUBUNIT: Interacts with ATP1B1. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK096949; BAC04909.1; -; mRNA. DR AlphaFoldDB; Q8N8D7; -. DR SMR; Q8N8D7; -. DR BioGRID; 130325; 53. DR STRING; 9606.ENSP00000429073; -. DR TCDB; 8.A.118.1.4; the na+k+-atpase beta-subunit interacting nkain (nkain) family. DR PhosphoSitePlus; Q8N8D7; -. DR BioMuta; NKAIN3; -. DR DMDM; 74729419; -. DR MassIVE; Q8N8D7; -. DR PaxDb; 9606-ENSP00000429073; -. DR PeptideAtlas; Q8N8D7; -. DR Antibodypedia; 63542; 10 antibodies from 6 providers. DR DNASU; 286183; -. DR Ensembl; ENST00000523211.5; ENSP00000429073.1; ENSG00000185942.13. DR UCSC; uc010lyq.2; human. DR AGR; HGNC:26829; -. DR GeneCards; NKAIN3; -. DR HGNC; HGNC:26829; NKAIN3. DR HPA; ENSG00000185942; Tissue enhanced (brain). DR MIM; 612872; gene. DR neXtProt; NX_Q8N8D7; -. DR OpenTargets; ENSG00000185942; -. DR PharmGKB; PA162397582; -. DR VEuPathDB; HostDB:ENSG00000185942; -. DR eggNOG; KOG4556; Eukaryota. DR GeneTree; ENSGT00940000161484; -. DR HOGENOM; CLU_090781_0_1_1; -. DR InParanoid; Q8N8D7; -. DR PhylomeDB; Q8N8D7; -. DR TreeFam; TF321348; -. DR PathwayCommons; Q8N8D7; -. DR SignaLink; Q8N8D7; -. DR ChiTaRS; NKAIN3; human. DR Pharos; Q8N8D7; Tdark. DR PRO; PR:Q8N8D7; -. DR Proteomes; UP000005640; Chromosome 8. DR RNAct; Q8N8D7; Protein. DR Bgee; ENSG00000185942; Expressed in ventricular zone and 119 other cell types or tissues. DR ExpressionAtlas; Q8N8D7; baseline and differential. DR Genevisible; Q8N8D7; HS. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central. DR InterPro; IPR008516; Na/K-Atpase_Interacting. DR PANTHER; PTHR13084:SF2; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 3; 1. DR PANTHER; PTHR13084; T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED; 1. DR Pfam; PF05640; NKAIN; 1. PE 2: Evidence at transcript level; KW Cell membrane; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..197 FT /note="Sodium/potassium-transporting ATPase subunit beta-1- FT interacting protein 3" FT /id="PRO_0000263093" FT TRANSMEM 2..22 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 35..55 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 62..82 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 152..172 FT /note="Helical" FT /evidence="ECO:0000255" FT VARIANT 140 FT /note="V -> I (in dbSNP:rs4739003)" FT /id="VAR_029583" SQ SEQUENCE 197 AA; 22620 MW; 1891A3188A9296DC CRC64; MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC DLQVCKHLFI QMLQIIE //