ID   NKAI3_HUMAN             Reviewed;         197 AA.
AC   Q8N8D7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   23-FEB-2022, entry version 120.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3;
DE            Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3;
DE   AltName: Full=Protein FAM77D;
GN   Name=NKAIN3; Synonyms=FAM77D;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SUBUNIT: Interacts with ATP1B1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}.
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DR   EMBL; AK096949; BAC04909.1; -; mRNA.
DR   BioGRID; 130325; 8.
DR   STRING; 9606.ENSP00000429073; -.
DR   TCDB; 8.A.118.1.4; the na+k+-atpase beta-subunit interacting nkain (nkain) family.
DR   PhosphoSitePlus; Q8N8D7; -.
DR   BioMuta; NKAIN3; -.
DR   DMDM; 74729419; -.
DR   MassIVE; Q8N8D7; -.
DR   PaxDb; Q8N8D7; -.
DR   PeptideAtlas; Q8N8D7; -.
DR   PRIDE; Q8N8D7; -.
DR   ProteomicsDB; 72403; -.
DR   Antibodypedia; 63542; 10 antibodies from 6 providers.
DR   DNASU; 286183; -.
DR   Ensembl; ENST00000523211; ENSP00000429073; ENSG00000185942.
DR   UCSC; uc010lyq.2; human.
DR   GeneCards; NKAIN3; -.
DR   HGNC; HGNC:26829; NKAIN3.
DR   HPA; ENSG00000185942; Tissue enriched (brain).
DR   MIM; 612872; gene.
DR   neXtProt; NX_Q8N8D7; -.
DR   OpenTargets; ENSG00000185942; -.
DR   PharmGKB; PA162397582; -.
DR   VEuPathDB; HostDB:ENSG00000185942; -.
DR   eggNOG; KOG4556; Eukaryota.
DR   GeneTree; ENSGT00940000161484; -.
DR   HOGENOM; CLU_090781_0_1_1; -.
DR   InParanoid; Q8N8D7; -.
DR   OrthoDB; 1281511at2759; -.
DR   PhylomeDB; Q8N8D7; -.
DR   TreeFam; TF321348; -.
DR   PathwayCommons; Q8N8D7; -.
DR   SignaLink; Q8N8D7; -.
DR   ChiTaRS; NKAIN3; human.
DR   Pharos; Q8N8D7; Tdark.
DR   PRO; PR:Q8N8D7; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q8N8D7; protein.
DR   Bgee; ENSG00000185942; Expressed in ventricular zone and 92 other tissues.
DR   ExpressionAtlas; Q8N8D7; baseline and differential.
DR   Genevisible; Q8N8D7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central.
DR   InterPro; IPR008516; Na/K-Atpase_Interacting.
DR   PANTHER; PTHR13084; PTHR13084; 1.
DR   Pfam; PF05640; NKAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..197
FT                   /note="Sodium/potassium-transporting ATPase subunit beta-1-
FT                   interacting protein 3"
FT                   /id="PRO_0000263093"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         140
FT                   /note="V -> I (in dbSNP:rs4739003)"
FT                   /id="VAR_029583"
SQ   SEQUENCE   197 AA;  22620 MW;  1891A3188A9296DC CRC64;
     MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR
     YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP
     PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC
     DLQVCKHLFI QMLQIIE
//