ID NKAI3_HUMAN Reviewed; 197 AA. AC Q8N8D7; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 26-FEB-2020, entry version 112. DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; DE Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3; DE AltName: Full=Protein FAM77D; GN Name=NKAIN3; Synonyms=FAM77D; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Small intestine; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). CC -!- SUBUNIT: Interacts with ATP1B1. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK096949; BAC04909.1; -; mRNA. DR SMR; Q8N8D7; -. DR STRING; 9606.ENSP00000429073; -. DR TCDB; 8.A.118.1.4; the na+k+-atpase beta-subunit interacting nkain (nkain) family. DR PhosphoSitePlus; Q8N8D7; -. DR BioMuta; NKAIN3; -. DR DMDM; 74729419; -. DR PaxDb; Q8N8D7; -. DR PeptideAtlas; Q8N8D7; -. DR PRIDE; Q8N8D7; -. DR ProteomicsDB; 72403; -. DR DNASU; 286183; -. DR Ensembl; ENST00000523211; ENSP00000429073; ENSG00000185942. DR UCSC; uc010lyq.2; human. DR DisGeNET; 286183; -. DR GeneCards; NKAIN3; -. DR HGNC; HGNC:26829; NKAIN3. DR HPA; HPA018833; -. DR MIM; 612872; gene. DR neXtProt; NX_Q8N8D7; -. DR OpenTargets; ENSG00000185942; -. DR PharmGKB; PA162397582; -. DR eggNOG; KOG4556; Eukaryota. DR eggNOG; ENOG410XS8X; LUCA. DR GeneTree; ENSGT00940000161484; -. DR HOGENOM; CLU_090781_0_1_1; -. DR InParanoid; Q8N8D7; -. DR OMA; TALWITW; -. DR OrthoDB; 1281511at2759; -. DR PhylomeDB; Q8N8D7; -. DR TreeFam; TF321348; -. DR ChiTaRS; NKAIN3; human. DR Pharos; Q8N8D7; Tdark. DR PRO; PR:Q8N8D7; -. DR Proteomes; UP000005640; Chromosome 8. DR RNAct; Q8N8D7; protein. DR Bgee; ENSG00000185942; Expressed in corpus callosum and 59 other tissues. DR ExpressionAtlas; Q8N8D7; baseline and differential. DR Genevisible; Q8N8D7; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central. DR InterPro; IPR008516; Na/K-Atpase_Interacting. DR PANTHER; PTHR13084; PTHR13084; 1. DR Pfam; PF05640; NKAIN; 1. PE 2: Evidence at transcript level; KW Cell membrane; Membrane; Polymorphism; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..197 FT /note="Sodium/potassium-transporting ATPase subunit beta-1- FT interacting protein 3" FT /id="PRO_0000263093" FT TRANSMEM 2..22 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 35..55 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 62..82 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 152..172 FT /note="Helical" FT /evidence="ECO:0000255" FT VARIANT 140 FT /note="V -> I (in dbSNP:rs4739003)" FT /id="VAR_029583" SQ SEQUENCE 197 AA; 22620 MW; 1891A3188A9296DC CRC64; MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC DLQVCKHLFI QMLQIIE //