ID CL076_HUMAN Reviewed; 135 AA. AC Q8N812; DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 11-DEC-2019, entry version 102. DE RecName: Full=Uncharacterized protein C12orf76; GN Name=C12orf76; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP VARIANT [LARGE SCALE ANALYSIS] THR-26. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK097461; BAC05063.1; -; mRNA. DR EMBL; BC133010; AAI33011.1; -; mRNA. DR EMBL; BC133012; AAI33013.1; -; mRNA. DR CCDS; CCDS9141.1; -. DR RefSeq; NP_997318.1; NM_207435.2. DR IntAct; Q8N812; 2. DR STRING; 9606.ENSP00000308368; -. DR BioMuta; C12orf76; -. DR PaxDb; Q8N812; -. DR PRIDE; Q8N812; -. DR ProteomicsDB; 72357; -. DR Ensembl; ENST00000652456; ENSP00000498468; ENSG00000174456. DR GeneID; 400073; -. DR KEGG; hsa:400073; -. DR UCSC; uc001tqd.2; human. DR CTD; 400073; -. DR DisGeNET; 400073; -. DR EuPathDB; HostDB:ENSG00000174456.13; -. DR GeneCards; C12orf76; -. DR HGNC; HGNC:33790; C12orf76. DR HPA; HPA039713; -. DR neXtProt; NX_Q8N812; -. DR OpenTargets; ENSG00000174456; -. DR PharmGKB; PA165512406; -. DR eggNOG; ENOG410KIJ4; Eukaryota. DR eggNOG; ENOG4110Q6M; LUCA. DR GeneTree; ENSGT00390000007263; -. DR HOGENOM; HOG000111776; -. DR InParanoid; Q8N812; -. DR OrthoDB; 1399936at2759; -. DR PhylomeDB; Q8N812; -. DR TreeFam; TF342372; -. DR ChiTaRS; C12orf76; human. DR GenomeRNAi; 400073; -. DR Pharos; Q8N812; Tdark. DR PRO; PR:Q8N812; -. DR Proteomes; UP000005640; Chromosome 12. DR RNAct; Q8N812; protein. DR Bgee; ENSG00000174456; Expressed in 196 organ(s), highest expression level in corpus callosum. DR ExpressionAtlas; Q8N812; baseline and differential. DR Genevisible; Q8N812; HS. DR InterPro; IPR041240; DUF5541. DR Pfam; PF17695; DUF5541; 1. PE 2: Evidence at transcript level; KW Polymorphism; Reference proteome. FT CHAIN 1..135 FT /note="Uncharacterized protein C12orf76" FT /id="PRO_0000325799" FT VARIANT 26 FT /note="A -> T (in a colorectal cancer sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_039916" SQ SEQUENCE 135 AA; 14959 MW; 42A798DE2376F0B3 CRC64; MFQNLQGTFE KEIGKIIPFT IAFKRAEAVE PDGCVQSWRC CLPCDLGQAS RFIHTTVCSA IRWRSCKGER NFAERHILPA ELEEQSNHAG MGPILPAMPS VDGNHFQHPA GDCHPYGILC LQAHSASVTA RQVLQ //