ID   GG6L1_HUMAN             Reviewed;         668 AA.
AC   Q8N7Z2; A0A087WU96;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 3.
DT   08-NOV-2023, entry version 118.
DE   RecName: Full=Golgin subfamily A member 6-like protein 1;
GN   Name=GOLGA6L1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}.
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DR   EMBL; AK097517; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC116165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS73699.1; -.
DR   RefSeq; NP_001001413.3; NM_001001413.3.
DR   AlphaFoldDB; Q8N7Z2; -.
DR   SMR; Q8N7Z2; -.
DR   STRING; 9606.ENSP00000478478; -.
DR   GlyGen; Q8N7Z2; 1 site, 1 O-linked glycan (1 site).
DR   PhosphoSitePlus; Q8N7Z2; -.
DR   BioMuta; GOLGA6L1; -.
DR   DMDM; 300669642; -.
DR   MassIVE; Q8N7Z2; -.
DR   PaxDb; 9606-ENSP00000478478; -.
DR   PeptideAtlas; Q8N7Z2; -.
DR   Antibodypedia; 74192; 13 antibodies from 4 providers.
DR   Ensembl; ENST00000611085.2; ENSP00000482864.1; ENSG00000278247.2.
DR   Ensembl; ENST00000614055.2; ENSP00000478478.1; ENSG00000273976.2.
DR   Ensembl; ENST00000616813.2; ENSP00000483916.1; ENSG00000275009.2.
DR   GeneID; 283767; -.
DR   KEGG; hsa:283767; -.
DR   MANE-Select; ENST00000614055.2; ENSP00000478478.1; NM_001001413.3; NP_001001413.3.
DR   UCSC; uc032bvr.2; human.
DR   AGR; HGNC:37444; -.
DR   CTD; 283767; -.
DR   GeneCards; GOLGA6L1; -.
DR   HGNC; HGNC:37444; GOLGA6L1.
DR   HPA; ENSG00000273976; Tissue enriched (testis).
DR   neXtProt; NX_Q8N7Z2; -.
DR   OpenTargets; ENSG00000273976; -.
DR   VEuPathDB; HostDB:ENSG00000273976; -.
DR   eggNOG; KOG4725; Eukaryota.
DR   GeneTree; ENSGT00940000163338; -.
DR   InParanoid; Q8N7Z2; -.
DR   OMA; QEENLWE; -.
DR   OrthoDB; 4706561at2759; -.
DR   PhylomeDB; Q8N7Z2; -.
DR   PathwayCommons; Q8N7Z2; -.
DR   BioGRID-ORCS; 283767; 262 hits in 663 CRISPR screens.
DR   ChiTaRS; GOLGA6L1; human.
DR   GenomeRNAi; 283767; -.
DR   Pharos; Q8N7Z2; Tdark.
DR   PRO; PR:Q8N7Z2; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q8N7Z2; Protein.
DR   Bgee; ENSG00000273976; Expressed in left testis and 17 other tissues.
DR   InterPro; IPR026737; GOLGA6L.
DR   PANTHER; PTHR23143:SF23; GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR23143; TRICHOHYALIN-RELATED; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..668
FT                   /note="Golgin subfamily A member 6-like protein 1"
FT                   /id="PRO_0000326027"
FT   REGION          1..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          481..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          177..663
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        9..44
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        491
FT                   /note="R -> W (in Ref. 1; AK097517)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   668 AA;  83069 MW;  6BEF9F37A46E1A6A CRC64;
     MLMWPQPHLP THPHLPTHPH LPTHPHLPTH PHLPTHPHLP THPHLPTHPM MSKETRQSKL
     AEAKEQLTDH HPQTNPSVGT AASDTKKKKI NNGTNPETTT SGGCHSPEDE QKASHQHQEA
     LRRELEAQVH TIRILTCQKT ELQMALYYSQ HAVKQLEGEA RDLISRLHDS WKFAGELEQA
     LSAVATQKKK ADRYIEELTK ERDALSLELY RNTITDEELK EKNAKLQEKL QLVESEKSEI
     QLNVKELKRK LERAKLLLPQ QQLQAEADHL GKELQSVSAK LQAQVEENEL WNRLNQQQEE
     KMWRQEEKIQ EWEEKIQEQE EKIREQEEKI REQEEKMRRQ EEMMWEKEEK MRRQEEMMWE
     KEEKMRRLEE MMWEKEEKIR ELEEKMHEQE KIREQEEKRQ EEEKIREQEK RQEQEAKMWR
     QEEKIREQEE KIREQEKKMW RQEEKIHEQE KIREEEKRQE QEEMWRQEEK IREQEEIWRQ
     KEKMHEQEKI RKQEEKVWRQ EEKMHDQEEK IREQEEKMWR QEEKIREQEE KIREQEEKIR
     EQEEMMQEQE EKMGEQEEKM QEQEKMRRQE EKIREQEEKI REQKEKIREQ EEKIWEQEEK
     IREQEEMMQE QEEKMWEQEE KMCEQEEKMQ EQEEKMRRQE EKMWEQEVRL RQQEEKMQEH
     QEHLEAAI
//