ID DCLK2_HUMAN Reviewed; 766 AA. AC Q8N568; Q8N399; DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 2. DT 29-MAY-2007, entry version 40. DE Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (Doublecortin-like DE and CAM kinase-like 2) (Doublecortin-like kinase 2). GN Name=DCLK2; Synonyms=DCAMKL2, DCDC3B, DCK2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-766 (ISOFORM 3). RC TISSUE=Amygdala; RG The German cDNA consortium; RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q8N568-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8N568-2; Sequence=VSP_012794; CC Name=3; CC IsoId=Q8N568-3; Sequence=VSP_012793; CC Name=4; CC IsoId=Q8N568-4; Sequence=VSP_012794, VSP_012795, VSP_012796; CC -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. CaMK CC subfamily. CC -!- SIMILARITY: Contains 2 doublecortin domains. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC032726; AAH32726.1; -; mRNA. DR EMBL; AL834498; CAD39156.1; -; mRNA. DR UniGene; Hs.591683; -. DR HSSP; O43602; 1MJD. DR SMR; Q8N568; 65-169. DR Ensembl; ENSG00000170390; Homo sapiens. DR KEGG; hsa:166614; -. DR HGNC; HGNC:19002; DCLK2. DR LinkHub; Q8N568; -. DR ArrayExpress; Q8N568; -. DR GermOnline; ENSG00000170390; Homo sapiens. DR InterPro; IPR003533; DCX. DR InterPro; IPR011009; Kinase_like. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR InterPro; IPR002290; Ser_thr_pkinase. DR Gene3D; G3DSA:1.10.510.10; G3DSA:1.10.510.10; 1. DR Gene3D; G3DSA:3.10.20.230; G3DSA:3.10.20.230; 2. DR Pfam; PF03607; DCX; 2. DR Pfam; PF00069; Pkinase; 1. DR ProDom; PD000001; Prot_kinase; 1. DR SMART; SM00537; DCX; 2. DR SMART; SM00220; S_TKc; 1. DR PROSITE; PS50309; DC; 2. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. KW Alternative splicing; ATP-binding; Kinase; Nucleotide-binding; Repeat; KW Serine/threonine-protein kinase; Transferase. FT CHAIN 1 766 Serine/threonine-protein kinase DCLK2. FT /FTId=PRO_0000085922. FT DOMAIN 72 158 Doublecortin 1. FT DOMAIN 197 280 Doublecortin 2. FT DOMAIN 394 651 Protein kinase. FT NP_BIND 400 408 ATP (By similarity). FT COMPBIAS 293 362 Ser-rich. FT COMPBIAS 713 753 Pro-rich. FT ACT_SITE 515 515 Proton acceptor (By similarity). FT BINDING 423 423 ATP (By similarity). FT VAR_SEQ 321 321 V -> VKRGGHYSSAYSTAKSPV (in isoform 3). FT /FTId=VSP_012793. FT VAR_SEQ 352 352 Missing (in isoform 2 and isoform 4). FT /FTId=VSP_012794. FT VAR_SEQ 692 696 NTVLD -> FDLTV (in isoform 4). FT /FTId=VSP_012795. FT VAR_SEQ 697 766 Missing (in isoform 4). FT /FTId=VSP_012796. SQ SEQUENCE 766 AA; 83640 MW; 10D6A6EB8EC1E83C CRC64; MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSSSGPK GNGLIPSPAH SAHCSFYRTR TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISSDRFRSFD ALLIELTRSL SDNVNLPQGV RTIYTIDGSR KVTSLDELLE GESYVCASNE PFRKVDYTKN INPNWSVNIK GGTSRALAAA SSVKSEVKES KDFIKPKLVT VIRSGVKPRK AVRILLNKKT AHSFEQVLTD ITEAIKLDSG VVKRLCTLDG KQVTCLQDFF GDDDVFIACG PEKFRYAQDD FVLDHSECRV LKSSYSRSSA VKYSGSKSPG PSRRSKSPAS VNGTPSSQLS TPKSTKSSSS SPTSPGSFRG LKQISAHGRS SSNVNGGPEL DRCISPEGVN GNRCSESSTL LEKYKIGKVI GDGNFAVVKE CIDRSTGKEF ALKIIDKAKC CGKEHLIENE VSILRRVKHP NIIMLVEEME TATELFLVME LVKGGDLFDA ITSSTKYTER DGSAMVYNLA NALRYLHGLS IVHRDIKPEN LLVCEYPDGT KSLKLGDFGL ATVVEGPLYT VCGTPTYVAP EIIAETGYGL KVDIWAAGVI TYILLCGFPP FRSENNLQED LFDQILAGKL EFPAPYWDNI TDSAKELISQ MLQVNVEARC TAGQILSHPW VSDDASQENN MQAEVTGKLK QHFNNALPKQ NSTTTGVSVI MNTVLDKEGQ IFCSKHCQDS GRPGMEPISP VPPSVEEIPV PGEAVPAPTP PESPTPHCPP AAPGGERAGT WRRHRD //