ID DCAK2_HUMAN STANDARD; PRT; 766 AA. AC Q8N568; Q8N399; DT 01-MAY-2005 (Rel. 47, Created) DT 01-MAY-2005 (Rel. 47, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE Serine/threonine-protein kinase DCAMKL2 (EC 2.7.1.37) (Doublecortin- DE like and CAM kinase-like 2). GN Name=DCAMKL2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Uterus; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-766 (ISOFORM 3). RC TISSUE=Amygdala; RG The German cDNA consortium; RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q8N568-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8N568-2; Sequence=VSP_012794; CC Name=3; CC IsoId=Q8N568-3; Sequence=VSP_012793; CC Name=4; CC IsoId=Q8N568-4; Sequence=VSP_012794, VSP_012795, VSP_012796; CC -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. CaMK CC subfamily. CC -!- SIMILARITY: Contains 2 doublecortin domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC032726; AAH32726.1; -. DR EMBL; AL834498; CAD39156.1; -. DR HSSP; O43602; 1MJD. DR Ensembl; ENSG00000170390; Homo sapiens. DR Genew; HGNC:19002; DCAMKL2. DR InterPro; IPR003533; DCX. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR InterPro; IPR002290; Ser_thr_pkinase. DR Pfam; PF03607; DCX; 2. DR Pfam; PF00069; Pkinase; 1. DR ProDom; PD000001; Prot_kinase; 1. DR SMART; SM00537; DCX; 2. DR SMART; SM00220; S_TKc; 1. DR PROSITE; PS50309; DC; 2. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. KW Alternative splicing; ATP-binding; Kinase; Repeat; KW Serine/threonine-protein kinase; Transferase. FT DOMAIN 72 158 Doublecortin 1. FT DOMAIN 197 280 Doublecortin 2. FT DOMAIN 293 362 Ser-rich. FT DOMAIN 394 651 Protein kinase. FT DOMAIN 713 753 Pro-rich. FT NP_BIND 400 408 ATP (By similarity). FT BINDING 423 423 ATP (By similarity). FT ACT_SITE 515 515 Proton acceptor (By similarity). FT VARSPLIC 321 321 V -> VKRGGHYSSAYSTAKSPV (in isoform 3). FT /FTId=VSP_012793. FT VARSPLIC 352 352 Missing (in isoform 2 and isoform 4). FT /FTId=VSP_012794. FT VARSPLIC 692 696 NTVLD -> FDLTV (in isoform 4). FT /FTId=VSP_012795. FT VARSPLIC 697 766 Missing (in isoform 4). FT /FTId=VSP_012796. SQ SEQUENCE 766 AA; 83640 MW; 10D6A6EB8EC1E83C CRC64; MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSSSGPK GNGLIPSPAH SAHCSFYRTR TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISSDRFRSFD ALLIELTRSL SDNVNLPQGV RTIYTIDGSR KVTSLDELLE GESYVCASNE PFRKVDYTKN INPNWSVNIK GGTSRALAAA SSVKSEVKES KDFIKPKLVT VIRSGVKPRK AVRILLNKKT AHSFEQVLTD ITEAIKLDSG VVKRLCTLDG KQVTCLQDFF GDDDVFIACG PEKFRYAQDD FVLDHSECRV LKSSYSRSSA VKYSGSKSPG PSRRSKSPAS VNGTPSSQLS TPKSTKSSSS SPTSPGSFRG LKQISAHGRS SSNVNGGPEL DRCISPEGVN GNRCSESSTL LEKYKIGKVI GDGNFAVVKE CIDRSTGKEF ALKIIDKAKC CGKEHLIENE VSILRRVKHP NIIMLVEEME TATELFLVME LVKGGDLFDA ITSSTKYTER DGSAMVYNLA NALRYLHGLS IVHRDIKPEN LLVCEYPDGT KSLKLGDFGL ATVVEGPLYT VCGTPTYVAP EIIAETGYGL KVDIWAAGVI TYILLCGFPP FRSENNLQED LFDQILAGKL EFPAPYWDNI TDSAKELISQ MLQVNVEARC TAGQILSHPW VSDDASQENN MQAEVTGKLK QHFNNALPKQ NSTTTGVSVI MNTVLDKEGQ IFCSKHCQDS GRPGMEPISP VPPSVEEIPV PGEAVPAPTP PESPTPHCPP AAPGGERAGT WRRHRD //