ID   RN175_HUMAN             Reviewed;         328 AA.
AC   Q8N4F7; C9JL66; Q8NB61;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   27-NOV-2024, entry version 158.
DE   RecName: Full=RING finger protein 175;
GN   Name=RNF175;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-322.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8N4F7; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10265447, EBI-10172290;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N4F7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N4F7-2; Sequence=VSP_055433, VSP_055434, VSP_055435,
CC                                  VSP_055436;
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DR   EMBL; AK091509; BAC03680.1; -; mRNA.
DR   EMBL; AC020703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471056; EAX04951.1; -; Genomic_DNA.
DR   EMBL; BC034385; AAH34385.1; -; mRNA.
DR   CCDS; CCDS47149.1; -. [Q8N4F7-1]
DR   RefSeq; NP_775933.1; NM_173662.2. [Q8N4F7-1]
DR   AlphaFoldDB; Q8N4F7; -.
DR   BioGRID; 130136; 5.
DR   IntAct; Q8N4F7; 3.
DR   STRING; 9606.ENSP00000340979; -.
DR   GlyCosmos; Q8N4F7; 1 site, 1 glycan.
DR   GlyGen; Q8N4F7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N4F7; -.
DR   PhosphoSitePlus; Q8N4F7; -.
DR   BioMuta; RNF175; -.
DR   DMDM; 296452878; -.
DR   jPOST; Q8N4F7; -.
DR   MassIVE; Q8N4F7; -.
DR   PaxDb; 9606-ENSP00000340979; -.
DR   PeptideAtlas; Q8N4F7; -.
DR   Antibodypedia; 27903; 81 antibodies from 16 providers.
DR   DNASU; 285533; -.
DR   Ensembl; ENST00000347063.9; ENSP00000340979.4; ENSG00000145428.15. [Q8N4F7-1]
DR   GeneID; 285533; -.
DR   KEGG; hsa:285533; -.
DR   MANE-Select; ENST00000347063.9; ENSP00000340979.4; NM_173662.4; NP_775933.2.
DR   UCSC; uc003int.4; human. [Q8N4F7-1]
DR   AGR; HGNC:27735; -.
DR   CTD; 285533; -.
DR   DisGeNET; 285533; -.
DR   GeneCards; RNF175; -.
DR   HGNC; HGNC:27735; RNF175.
DR   HPA; ENSG00000145428; Tissue enhanced (brain).
DR   neXtProt; NX_Q8N4F7; -.
DR   OpenTargets; ENSG00000145428; -.
DR   PharmGKB; PA134909663; -.
DR   VEuPathDB; HostDB:ENSG00000145428; -.
DR   eggNOG; KOG1734; Eukaryota.
DR   GeneTree; ENSGT00390000013075; -.
DR   HOGENOM; CLU_055016_1_0_1; -.
DR   InParanoid; Q8N4F7; -.
DR   OMA; PYWERTH; -.
DR   OrthoDB; 10447at2759; -.
DR   PhylomeDB; Q8N4F7; -.
DR   TreeFam; TF314357; -.
DR   PathwayCommons; Q8N4F7; -.
DR   SignaLink; Q8N4F7; -.
DR   SIGNOR; Q8N4F7; -.
DR   BioGRID-ORCS; 285533; 10 hits in 1186 CRISPR screens.
DR   ChiTaRS; RNF175; human.
DR   GenomeRNAi; 285533; -.
DR   Pharos; Q8N4F7; Tdark.
DR   PRO; PR:Q8N4F7; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q8N4F7; protein.
DR   Bgee; ENSG00000145428; Expressed in middle temporal gyrus and 138 other cell types or tissues.
DR   ExpressionAtlas; Q8N4F7; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0036503; P:ERAD pathway; IBA:GO_Central.
DR   CDD; cd16475; RING-H2_RNF121-like; 1.
DR   FunFam; 3.30.40.10:FF:000074; Ring finger protein 121; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR040176; RNF121/RNF175.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13407:SF2; RING FINGER PROTEIN 175; 1.
DR   PANTHER; PTHR13407; RNF121 PROTEIN; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Metal-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..328
FT                   /note="RING finger protein 175"
FT                   /id="PRO_0000245599"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         227..277
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   VAR_SEQ         1..6
FT                   /note="MAAGTA -> MADPTI (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_055433"
FT   VAR_SEQ         7..134
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_055434"
FT   VAR_SEQ         256..309
FT                   /note="FHEFCIRGWCIVGKKQTCPYCKEKVDLKRMISNPWERTHFLYGQILDWLRYL
FT                   VA -> YPFQRKLFGLHQASFFPPSPPPPPVPISSILLTFHAQTPVLYPPAQSSLPVCP
FT                   C (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_055435"
FT   VAR_SEQ         310..328
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_055436"
FT   VARIANT         159
FT                   /note="M -> V (in dbSNP:rs10517577)"
FT                   /id="VAR_026998"
FT   VARIANT         307
FT                   /note="L -> F (in dbSNP:rs1337)"
FT                   /id="VAR_026999"
FT   VARIANT         315
FT                   /note="I -> M (in dbSNP:rs1339)"
FT                   /id="VAR_027000"
FT   VARIANT         322
FT                   /note="I -> N (in dbSNP:rs2405432)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_027001"
SQ   SEQUENCE   328 AA;  38266 MW;  A9EAAE7B4A75B524 CRC64;
     MAAGTAARKA APVLEAPPQQ EQLSHTKLSA EDTWNLQQER MYKMHRGHDS MHVEMILIFL
     CVLVIAQIVL VQWRQRHGRS YNLVTLLQMW VVPLYFTIKL YWWRFLSMWG MFSVITSYIL
     FRATRKPLSG RTPRLVYKWF LLIYKLSYAF GVVGYLAIMF TMCGFNLFFK IKARDSMDFG
     IVSLFYGLYY GVMGRDFAEI CSDYMASTIG FYSVSRLPTR SLSDNICAVC GQKIIVELDE
     EGLIENTYQL SCNHVFHEFC IRGWCIVGKK QTCPYCKEKV DLKRMISNPW ERTHFLYGQI
     LDWLRYLVAW QPVVIGIVQG IIYSLGLE
//