ID   DEPD4_HUMAN             Reviewed;         294 AA.
AC   Q8N2C3; Q496C8; Q96BW0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   08-NOV-2023, entry version 132.
DE   RecName: Full=DEP domain-containing protein 4;
GN   Name=DEPDC4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 34-294 (ISOFORM 1).
RC   TISSUE=Urinary bladder;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N2C3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N2C3-2; Sequence=VSP_024646, VSP_024647;
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DR   EMBL; AK090824; BAC03525.1; -; mRNA.
DR   EMBL; BC015117; AAH15117.1; -; mRNA.
DR   EMBL; BC100929; AAI00930.1; -; mRNA.
DR   CCDS; CCDS9075.1; -. [Q8N2C3-1]
DR   RefSeq; NP_001306239.1; NM_001319310.1.
DR   RefSeq; NP_689530.1; NM_152317.3. [Q8N2C3-1]
DR   AlphaFoldDB; Q8N2C3; -.
DR   STRING; 9606.ENSP00000396234; -.
DR   iPTMnet; Q8N2C3; -.
DR   PhosphoSitePlus; Q8N2C3; -.
DR   BioMuta; DEPDC4; -.
DR   DMDM; 74728709; -.
DR   PaxDb; 9606-ENSP00000396234; -.
DR   PeptideAtlas; Q8N2C3; -.
DR   Antibodypedia; 51125; 25 antibodies from 16 providers.
DR   DNASU; 120863; -.
DR   Ensembl; ENST00000299185.12; ENSP00000299185.8; ENSG00000166153.17. [Q8N2C3-2]
DR   Ensembl; ENST00000378244.6; ENSP00000367490.2; ENSG00000166153.17. [Q8N2C3-1]
DR   Ensembl; ENST00000416321.5; ENSP00000396234.1; ENSG00000166153.17. [Q8N2C3-1]
DR   Ensembl; ENST00000549341.1; ENSP00000447392.1; ENSG00000166153.17. [Q8N2C3-2]
DR   GeneID; 120863; -.
DR   KEGG; hsa:120863; -.
DR   UCSC; uc001thh.2; human. [Q8N2C3-1]
DR   AGR; HGNC:22952; -.
DR   CTD; 120863; -.
DR   DisGeNET; 120863; -.
DR   GeneCards; DEPDC4; -.
DR   HGNC; HGNC:22952; DEPDC4.
DR   HPA; ENSG00000166153; Tissue enhanced (testis).
DR   neXtProt; NX_Q8N2C3; -.
DR   OpenTargets; ENSG00000166153; -.
DR   PharmGKB; PA134981607; -.
DR   VEuPathDB; HostDB:ENSG00000166153; -.
DR   eggNOG; ENOG502QW4D; Eukaryota.
DR   GeneTree; ENSGT00950000182976; -.
DR   HOGENOM; CLU_3092752_0_0_1; -.
DR   InParanoid; Q8N2C3; -.
DR   OMA; LWEGIIH; -.
DR   OrthoDB; 3108805at2759; -.
DR   PhylomeDB; Q8N2C3; -.
DR   PathwayCommons; Q8N2C3; -.
DR   BioGRID-ORCS; 120863; 12 hits in 1150 CRISPR screens.
DR   ChiTaRS; DEPDC4; human.
DR   GenomeRNAi; 120863; -.
DR   Pharos; Q8N2C3; Tdark.
DR   PRO; PR:Q8N2C3; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8N2C3; Protein.
DR   Bgee; ENSG00000166153; Expressed in ventricular zone and 91 other tissues.
DR   ExpressionAtlas; Q8N2C3; baseline and differential.
DR   Genevisible; Q8N2C3; HS.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04446; DEP_DEPDC4; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR16206; DEP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR16206:SF10; DEP DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF00610; DEP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..294
FT                   /note="DEP domain-containing protein 4"
FT                   /id="PRO_0000284783"
FT   DOMAIN          71..162
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   VAR_SEQ         53..57
FT                   /note="GCSGP -> DQDMK (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024646"
FT   VAR_SEQ         58..294
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024647"
FT   VARIANT         122
FT                   /note="H -> R (in dbSNP:rs7307415)"
FT                   /id="VAR_031815"
FT   CONFLICT        34
FT                   /note="L -> G (in Ref. 2; AAH15117)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   294 AA;  33694 MW;  0073B8E83402EA43 CRC64;
     MVPGEEPARE LMAVLLTPRF RRLVSQNELP GPGLNGPSSR NRRDGFCRKR RTGCSGPFQA
     TQLWDGIIHS LQAQVEIKRR RHHLQTYKDC FTGSDAVDVV LSHLMQNTCL SSNDISCLKG
     VHLCQVLMNH KVFEPVGMKK LFKKEKELEF EDSNISLYRF LGNKSSYDCC KRQKDAENEF
     NETLRPGYEM ISNPLAQEIG EERIEELIHT INGNPALCPN ITVQKPFLRL SKEDVWKEQT
     LLCLLQLIHL PFLDNILEPP VKTQNLQLNK EEDLVITNTC LDRELIPSLC LPEK
//