ID NUP93_HUMAN Reviewed; 819 AA. AC Q8N1F7; Q14705; DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot. DT 17-OCT-2006, sequence version 2. DT 13-OCT-2009, entry version 59. DE RecName: Full=Nuclear pore complex protein Nup93; DE AltName: Full=Nucleoporin Nup93; DE AltName: Full=93 kDa nucleoporin; GN Name=NUP93; Synonyms=KIAA0095; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Bone marrow; RX MEDLINE=95308325; PubMed=7788527; DOI=10.1093/dnares/2.1.37; RA Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., RA Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.; RT "Prediction of the coding sequences of unidentified human genes. III. RT The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by RT analysis of cDNA clones from human cell line KG-1."; RL DNA Res. 2:37-43(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-509. RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP CHARACTERIZATION. RX PubMed=9348540; RA Grandi P., Dang T., Pane N., Shevchenko A., Mann M., Forbes D., RA Hurt E.; RT "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a RT novel 205-kDa protein and is required for correct nuclear pore RT assembly."; RL Mol. Biol. Cell 8:2017-2038(1997). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-767, AND MASS RP SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=17924679; DOI=10.1021/pr070152u; RA Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; RT "Improved titanium dioxide enrichment of phosphopeptides from HeLa RT cells and high confident phosphopeptide identification by cross- RT validation of MS/MS and MS/MS/MS spectra."; RL J. Proteome Res. 6:4150-4162(2007). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, AND MASS RP SPECTROMETRY. RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of RT the kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-72, AND MASS RP SPECTROMETRY. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [7] RP IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY. RA Colinge J., Superti-Furga G., Bennett K.L.; RL Submitted (OCT-2008) to UniProtKB. CC -!- FUNCTION: Part of the nucleoporin complex; required for correct CC nuclear pore assembly. CC -!- SUBUNIT: Component of the p62 complex, a complex composed of CC NUP62, NUP54. Interacts also with NUP205. CC -!- INTERACTION: CC Q9HAW0:BRF2; NbExp=1; IntAct=EBI-1042703, EBI-1055224; CC P49662:CASP4; NbExp=1; IntAct=EBI-1042703, EBI-1057327; CC O14908:GIPC1; NbExp=1; IntAct=EBI-1042703, EBI-373132; CC Q9HC98:NEK6; NbExp=1; IntAct=EBI-1042703, EBI-740364; CC Q99623:PHB2; NbExp=1; IntAct=EBI-1042703, EBI-358348; CC Q9Y5J5:PHLDA3; NbExp=1; IntAct=EBI-1042703, EBI-1055859; CC Q96T60:PNKP; NbExp=1; IntAct=EBI-1042703, EBI-1045072; CC Q15714:TSC22D1; NbExp=1; IntAct=EBI-1042703, EBI-712609; CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. CC Note=Localizes at the nuclear basket and at or near the nuclear CC entry to the gated channel of the pore. CC -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D42085; BAA07680.2; ALT_INIT; mRNA. DR EMBL; BC034346; AAH34346.1; -; mRNA. DR IPI; IPI00397904; -. DR RefSeq; NP_055484.3; -. DR UniGene; Hs.276878; -. DR IntAct; Q8N1F7; 17. DR STRING; Q8N1F7; -. DR PhosphoSite; Q8N1F7; -. DR PRIDE; Q8N1F7; -. DR Ensembl; ENST00000308159; ENSP00000310668; ENSG00000102900; Homo sapiens. DR GeneID; 9688; -. DR KEGG; hsa:9688; -. DR UCSC; uc002eka.1; human. DR CTD; 9688; -. DR GeneCards; GC16P055322; -. DR H-InvDB; HIX0013063; -. DR HGNC; HGNC:28958; NUP93. DR HPA; HPA017937; -. DR PharmGKB; PA134912759; -. DR HOGENOM; Q8N1F7; -. DR HOVERGEN; Q8N1F7; -. DR OMA; Q8N1F7; LTAQFEA. DR Reactome; REACT_6185; HIV Infection. DR NextBio; 36387; -. DR ArrayExpress; Q8N1F7; -. DR Bgee; Q8N1F7; -. DR CleanEx; HS_NUP93; -. DR Genevestigator; Q8N1F7; -. DR GermOnline; ENSG00000102900; Homo sapiens. DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR GO; GO:0055085; P:transmembrane transport; IEA:UniProtKB-KW. DR InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96. DR PANTHER; PTHR11225; NIC; 1. DR Pfam; PF04097; Nic96; 1. PE 1: Evidence at protein level; KW Complete proteome; mRNA transport; Nuclear pore complex; Nucleus; KW Phosphoprotein; Polymorphism; Protein transport; Translocation; KW Transport. FT CHAIN 1 819 Nuclear pore complex protein Nup93. FT /FTId=PRO_0000124782. FT MOD_RES 52 52 Phosphoserine. FT MOD_RES 72 72 Phosphoserine. FT MOD_RES 430 430 Phosphoserine. FT MOD_RES 767 767 Phosphoserine. FT VARIANT 509 509 S -> R (in dbSNP:rs17853288). FT /FTId=VAR_028160. SQ SEQUENCE 819 AA; 93488 MW; 7A611FABE964FE98 CRC64; MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYISDV GPPGRSSLDN IEMAYARQIY IYNEKIVNGH LQPNLVDLCA SVAELDDKSI SDMWTMVKQM TDVLLTPATD ALKNRSSVEV RMEFVRQALA YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK LPAPLPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVNR AQHQLGEFKT WFQEYMNSKD RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDVT DNQSEVADKT EDYLWLKLNQ VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAVAFLF RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCLRRLNFVR LLMLYTRKFE STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIERLKLV PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS SSRPQRVIED RDSQLRSQAR TLITFAGMIP YRTSGDTNAR LVQMEVLMN //