ID   FUK_HUMAN      STANDARD;      PRT;  1084 AA.
AC   Q8N0W3; Q5PSM3; Q5XKL6; Q6ZRA0; Q96MT9;
DT   28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   03-OCT-2006, entry version 38.
DE   L-fucose kinase (EC 2.7.1.52) (Fucokinase).
GN   Name=FUK;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   MEDLINE=22052376; PubMed=12056818; DOI=10.1016/S0006-291X(02)00541-7;
RA   Hinderlich S., Berger M., Blume A., Chen H., Ghaderi D., Bauer C.;
RT   "Identification of human L-fucose kinase amino acid sequence.";
RL   Biochem. Biophys. Res. Commun. 294:650-654(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-146; THR-521;
RP   HIS-571; LEU-701; THR-858; MET-861; TRP-901; GLN-939 AND TRP-939.
RA   Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O.,
RA   Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.;
RT   "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-
RT   FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu).";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Neuron, and Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Takes part in the salvage pathway for reutilization of
CC       fucose from the degradation of oligosaccharides.
CC   -!- CATALYTIC ACTIVITY: ATP + L-fucose = ADP + beta-L-fucose 1-
CC       phosphate.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N0W3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N0W3-2; Sequence=VSP_015422, VSP_015423;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the GHMP kinase family.
CC   -!- CAUTION: Ref.1 and Ref.3 (BAB71190) sequences differ from that
CC       shown due to a frameshift in position 19.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ441184; CAD29647.1; ALT_FRAME; mRNA.
DR   EMBL; AY829643; AAV67949.1; -; Genomic_DNA.
DR   EMBL; AK056456; BAB71190.1; ALT_FRAME; mRNA.
DR   EMBL; AK128387; BAC87413.1; -; mRNA.
DR   EMBL; BC013735; AAH13735.1; -; mRNA.
DR   EMBL; BC032542; AAH32542.2; -; mRNA.
DR   UniGene; Hs.599138; -.
DR   UniGene; Hs.7907; -.
DR   Ensembl; ENSG00000157353; Homo sapiens.
DR   KEGG; hsa:197258; -.
DR   HGNC; HGNC:29500; FUK.
DR   MIM; 608675; gene.
DR   ArrayExpress; Q8N0W3; -.
DR   RZPD-ProtExp; T5214; -.
DR   GO; GO:0050201; F:fucokinase activity; NAS.
DR   InterPro; IPR012887; Fucokinase.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd.
DR   InterPro; IPR012370; L-fuc_kin.
DR   InterPro; IPR006206; Mev_galkinase.
DR   Pfam; PF07959; Fucokinase; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF036405; L-fuc_kin; 1.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; FALSE_NEG.
KW   Alternative splicing; ATP-binding; Kinase; Nucleotide-binding;
KW   Polymorphism; Transferase.
FT   CHAIN         1   1084       L-fucose kinase.
FT                                /FTId=PRO_0000156672.
FT   NP_BIND     834    845       ATP (Potential).
FT   VAR_SEQ      78     78       T -> TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ
FT                                (in isoform 2).
FT                                /FTId=VSP_015422.
FT   VAR_SEQ     816    841       Missing (in isoform 2).
FT                                /FTId=VSP_015423.
FT   VARIANT     146    146       V -> M.
FT                                /FTId=VAR_021327.
FT   VARIANT     521    521       A -> T.
FT                                /FTId=VAR_021328.
FT   VARIANT     571    571       R -> H.
FT                                /FTId=VAR_021329.
FT   VARIANT     701    701       P -> L.
FT                                /FTId=VAR_021330.
FT   VARIANT     858    858       A -> T.
FT                                /FTId=VAR_021331.
FT   VARIANT     861    861       V -> M.
FT                                /FTId=VAR_021332.
FT   VARIANT     901    901       R -> W.
FT                                /FTId=VAR_021333.
FT   VARIANT     939    939       R -> Q.
FT                                /FTId=VAR_021334.
FT   VARIANT     939    939       R -> W.
FT                                /FTId=VAR_021335.
FT   CONFLICT    400    400       L -> S (in Ref. 3; BAB71190).
FT   CONFLICT    609    609       C -> R (in Ref. 3; BAB71190).
SQ   SEQUENCE   1084 AA;  117623 MW;  153F91882F4B143C CRC64;
     MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT
     LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP FDDCGRAFTC LPVENPEAPV
     EALVCNLDCL LDIMTYRLGP GSPPGVWVCS TDMLLSVPAN PGISWDSFRG ARVIALPGSP
     AYAQNHGVYL TDPQGLVLDI YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH
     VSPPLDACTY LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL
     QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI VHSQVEEQQL
     LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL VTGLDTAHSK ALHGRELRDL
     VLQGHHTRLH GSPGHAFTLV GRLDSWERQG AGTYLNVPWS EFFKRTGVRA WDLWDPETLP
     AEYCLPSARL FPVLHPSREL GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA
     ATLASRRDLF FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP
     GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV EALAQERDKW
     LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL PGPGQWVVAE CPARVDFSGG
     WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA RARRIPEPEL WLAVGPRQDE MTVKIVCRCL
     ADLRDYCQPH APGALLKAAF ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL
     GTSSILAGTA LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS
     RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY ARLPAVVQNA
     HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC EPLTVRRMMD VLAPHVHGQS
     LAGAGGGGFL YLLTKEPQQK EALEAVLAKT EGLGNYSIHL VEVDTQGLSL KLLGTEASTC
     CPFP
//