ID Q8MY87_HEMPU PRELIMINARY; PRT; 250 AA. AC Q8MY87; DT 01-OCT-2002 (TrEMBLrel. 22, Created) DT 01-OCT-2002 (TrEMBLrel. 22, Last sequence update) DT 01-OCT-2003 (TrEMBLrel. 25, Last annotation update) DE TATA binding protein. GN Name=TBP; OS Hemicentrotus pulcherrimus (Sea urchin). OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; OC Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; OC Hemicentrotus. OX NCBI_TaxID=7650; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22131754; PubMed=12136085; DOI=10.1093/nar/gkf439; RA Kobayashi A., Akasaka K., Kawaichi M., Kokubo T.; RT "Functional interaction between TATA and upstream CACGTG elements RT regulates the temporally specific expression of Otx mRNAs during early RT embryogenesis of the sea urchin, Hemicentrotus pulcherrimus."; RL Nucleic Acids Res. 30:3034-3044(2002). CC -!- FUNCTION: General transcription factor that functions at the core CC of the DNA-binding multiprotein factor TFIID. Binding of TFIID to CC the TATA box is the initial transcriptional step of the pre- CC initiation complex (PIC), playing a role in the activation of CC eukaryotic genes transcribed by RNA polymerase II (By similarity). CC -!- SUBUNIT: Belongs to the TFIID complex together with the TBP- CC associated factors (TAFs). Binds DNA as monomer (By similarity). CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity). CC -!- SIMILARITY: Belongs to the TBP family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB074420; BAB92075.1; -. DR HSSP; P20226; 1TGH. DR GO; GO:0005634; C:nucleus; IEA. DR GO; GO:0005669; C:transcription factor TFIID complex; IEA. DR GO; GO:0003677; F:DNA binding; IEA. DR GO; GO:0003702; F:RNA polymerase II transcription factor acti...; IEA. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA. DR GO; GO:0006367; P:transcription initiation from Pol II promoter; IEA. DR InterPro; IPR000814; TFIID. DR Pfam; PF00352; TBP; 2. DR PRINTS; PR00686; TIFACTORIID. DR PROSITE; PS00351; TFIID; 2. KW DNA-binding; Nuclear protein. SQ SEQUENCE 250 AA; 27375 MW; 3E5654EEE14D4F16 CRC64; MDNQDGGQQR SHYPQISSQQ SQSYLSVPSI GTPSFGSVGS VSSLAPGSSF IPPSPMAPLT PATPASSESS GIVPQLQNIV STVNLNCRLD LKKIALHARN AEYNPKRFAA VIMRIREPRT TALIFSSGKM VCTGAKSEDD SRLAARKYAR VVQKLGFAAK FLDFKIQNMV GSCDVKFPIR LEGLVLTHGQ FSSYEPELFP GLIYRMVKPR IVLLIFVSGK VVLTGAKVRQ EIYDAFNNIY PILKSFKKTS //