ID IDGF1_DROYA Reviewed; 439 AA. AC Q8MX40; DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 25-MAY-2022, entry version 92. DE RecName: Full=Chitinase-like protein Idgf1; DE AltName: Full=Imaginal disk growth factor protein 1; DE Flags: Precursor; GN Name=Idgf1; OS Drosophila yakuba (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7245; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=#14021-0261.0; RX PubMed=12242232; DOI=10.1093/genetics/162.1.177; RA Zurovcova M., Ayala F.J.; RT "Polymorphism patterns in two tightly linked developmental genes, Idgf1 and RT Idgf3, of Drosophila melanogaster."; RL Genetics 162:177-188(2002). CC -!- FUNCTION: Cooperates with insulin-like peptides to stimulate the CC proliferation, polarization and motility of imaginal disk cells. May CC act by stabilizing the binding of insulin-like peptides to its receptor CC through a simultaneous interaction with both molecules to form a CC multiprotein signaling complex (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted in CC hemolymph. It is probably transported to target tissues via hemolymph. CC {ECO:0000250}. CC -!- PTM: Glycosylated. {ECO:0000250}. CC -!- MISCELLANEOUS: Lacks the typical Glu active site in position 150 that CC is replaced by a Gln residue, preventing the hydrolase activity. Its CC precise function remains unclear. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. IDGF CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF394712; AAM69644.1; -; Genomic_DNA. DR AlphaFoldDB; Q8MX40; -. DR SMR; Q8MX40; -. DR STRING; 7245.FBpp0258117; -. DR CAZy; GH18; Glycoside Hydrolase Family 18. DR eggNOG; KOG2806; Eukaryota. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008061; F:chitin binding; IEA:InterPro. DR GO; GO:0008084; F:imaginal disc growth factor receptor binding; ISS:UniProtKB. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR GO; GO:0040003; P:chitin-based cuticle development; IEA:EnsemblMetazoa. DR GO; GO:0018990; P:ecdysis, chitin-based cuticle; IEA:EnsemblMetazoa. DR GO; GO:1990399; P:epithelium regeneration; IEA:EnsemblMetazoa. DR GO; GO:0007444; P:imaginal disc development; ISS:UniProtKB. DR GO; GO:2000035; P:regulation of stem cell division; IEA:EnsemblMetazoa. DR GO; GO:0042060; P:wound healing; IEA:EnsemblMetazoa. DR CDD; cd02873; GH18_IDGF; 1. DR Gene3D; 3.10.50.10; -; 1. DR InterPro; IPR011583; Chitinase_II. DR InterPro; IPR029070; Chitinase_insertion_sf. DR InterPro; IPR001223; Glyco_hydro18_cat. DR InterPro; IPR017853; Glycoside_hydrolase_SF. DR InterPro; IPR015520; IDGF. DR PANTHER; PTHR11177:SF235; PTHR11177:SF235; 1. DR Pfam; PF00704; Glyco_hydro_18; 1. DR SMART; SM00636; Glyco_18; 1. DR SUPFAM; SSF51445; SSF51445; 1. DR SUPFAM; SSF54556; SSF54556; 1. DR PROSITE; PS51910; GH18_2; 1. PE 3: Inferred from homology; KW Developmental protein; Disulfide bond; Glycoprotein; Secreted; Signal. FT SIGNAL 1..20 FT /evidence="ECO:0000250" FT CHAIN 21..439 FT /note="Chitinase-like protein Idgf1" FT /id="PRO_0000011982" FT DOMAIN 22..439 FT /note="GH18" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01258" FT CARBOHYD 122 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 218 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000250" FT CARBOHYD 346 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 26..53 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01258" FT DISULFID 340..423 FT /evidence="ECO:0000250" SQ SEQUENCE 439 AA; 49244 MW; EDE16BFD82A18B9E CRC64; MRFQLCYLLG LLSVTSLSHA ASNLICYYDS TSYLRQGLAK MHTHELDLAL QFCTHLVYGY AGLKAGTLEL FSLNVDLDMF YYKEITALRQ KFPQLKILLS VGGDRDVDEA HPNKYVELLE ANRTFQQNFI DSSMILVKRN GFDGLDLAFQ LPRNKPRKVH GSLGTYWKSF KKLFTGDFVV DPLAEQHKSQ FTDLVGNLKN AFRSANLMLS LTVLPNVNST WYFDVPKLHP QFEYINLAAF DFLTPVRNPE EADFTAPIFF QDEQNRLPHL NVEFQVNYWL QNNCPGQKLN LGIASYGRAW KLSKGSGLSG APIVQETCGA APGGIQIQSA DGLLSWPEIC SKLSQNASAQ YRGEMAPLRK VTDLTQKYGN YALRPADDNG DFGVWLSFDD PDFAGIKAAY AKGKGLGGVA IFDLSYDDFR GLCTGQKFPI VRSIKYFMG //