ID IDGF1_DROYA Reviewed; 439 AA. AC Q8MX40; DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 12-DEC-2006, entry version 24. DE Chitinase-like protein Idgf1 precursor (Imaginal disk growth factor DE protein 1). GN Name=Idgf1; OS Drosophila yakuba (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7245; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=#14021-0261.0; RX MEDLINE=22226651; PubMed=12242232; RA Zurovcova M., Ayala F.J.; RT "Polymorphism patterns in two tightly linked developmental genes, RT Idgf1 and Idgf3, of Drosophila melanogaster."; RL Genetics 162:177-188(2002). CC -!- FUNCTION: Cooperates with insulin-like peptides to stimulate the CC proliferation, polarization and motility of imaginal disk cells. CC May act by stabilizing the binding of insulin-like peptides to its CC receptor through a simultaneous interaction with both molecules to CC form a multiprotein signaling complex (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted protein (By similarity). CC Note=Secreted in hemolymph (By similarity). It is probably CC transported to target tissues via hemolymph (By similarity). CC -!- PTM: Glycosylated (By similarity). CC -!- MISCELLANEOUS: Lacks the typical Glu active site in position 150 CC that is replaced by a Gln residue, preventing the hydrolase CC activity. Its precise function remains unclear. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. IDGF CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF394712; AAM69644.1; -; Genomic_DNA. DR HSSP; O96665; 1JND. DR FlyBase; FBgn0044136; Dyak\Idgf1. DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB. DR GO; GO:0008084; F:imaginal disc growth factor activity; ISS:UniProtKB. DR GO; GO:0007444; P:imaginal disc development; ISS:UniProtKB. DR InterPro; IPR011583; Chitinase_II. DR InterPro; IPR001223; Glyco_hydro18cat. DR InterPro; IPR013781; Glyco_hydro_cat. DR Pfam; PF00704; Glyco_hydro_18; 1. DR ProDom; PD000471; Chitinase_II; 1. DR SMART; SM00636; Glyco_18; 1. KW Developmental protein; Glycoprotein; Signal. FT SIGNAL 1 20 By similarity. FT CHAIN 21 439 Chitinase-like protein Idgf1. FT /FTId=PRO_0000011982. FT CARBOHYD 122 122 N-linked (GlcNAc...) (Potential). FT CARBOHYD 218 218 N-linked (GlcNAc...) (By similarity). FT CARBOHYD 346 346 N-linked (GlcNAc...) (Potential). FT DISULFID 26 53 By similarity. FT DISULFID 340 423 By similarity. SQ SEQUENCE 439 AA; 49244 MW; EDE16BFD82A18B9E CRC64; MRFQLCYLLG LLSVTSLSHA ASNLICYYDS TSYLRQGLAK MHTHELDLAL QFCTHLVYGY AGLKAGTLEL FSLNVDLDMF YYKEITALRQ KFPQLKILLS VGGDRDVDEA HPNKYVELLE ANRTFQQNFI DSSMILVKRN GFDGLDLAFQ LPRNKPRKVH GSLGTYWKSF KKLFTGDFVV DPLAEQHKSQ FTDLVGNLKN AFRSANLMLS LTVLPNVNST WYFDVPKLHP QFEYINLAAF DFLTPVRNPE EADFTAPIFF QDEQNRLPHL NVEFQVNYWL QNNCPGQKLN LGIASYGRAW KLSKGSGLSG APIVQETCGA APGGIQIQSA DGLLSWPEIC SKLSQNASAQ YRGEMAPLRK VTDLTQKYGN YALRPADDNG DFGVWLSFDD PDFAGIKAAY AKGKGLGGVA IFDLSYDDFR GLCTGQKFPI VRSIKYFMG //