ID Q8MQX9_DROME Unreviewed; 1174 AA. AC Q8MQX9; Q0KHR1; DT 01-OCT-2002, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 1. DT 10-OCT-2018, entry version 125. DE SubName: Full=Ankyrin repeat and LEM domain containing 2, isoform D {ECO:0000313|EMBL:AAF48735.2}; DE SubName: Full=Ankyrin repeat and LEM domain containing 2, isoform E {ECO:0000313|EMBL:AAF48736.2}; DE SubName: Full=SD02148p {ECO:0000313|EMBL:AAM52753.1}; GN Name=Ankle2 {ECO:0000313|EMBL:AAF48735.2, GN ECO:0000313|FlyBase:FBgn0028343}; GN Synonyms=anon-WO03040301.175 {ECO:0000313|EMBL:AAF48735.2}, GN anon-WO03040301.177 {ECO:0000313|EMBL:AAF48735.2}, anon-WO03040301.179 GN {ECO:0000313|EMBL:AAF48735.2}, dAnkle2 {ECO:0000313|EMBL:AAF48735.2}, GN Dmel\CG8465 {ECO:0000313|EMBL:AAF48735.2}, l(1)G0222 GN {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|FlyBase:FBgn0028343}, GN l(1)G0316 {ECO:0000313|EMBL:AAF48735.2}; GN ORFNames=CG8465 {ECO:0000313|EMBL:AAM52753.1, GN ECO:0000313|FlyBase:FBgn0028343}, Dmel_CG8465 GN {ECO:0000313|EMBL:AAF48735.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM52753.1}; RN [1] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAM52753.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF48735.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF48735.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF48735.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF48735.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAF48735.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAF48735.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AAF48735.2; -; Genomic_DNA. DR EMBL; AE014298; AAF48736.2; -; Genomic_DNA. DR EMBL; AY122241; AAM52753.1; -; mRNA. DR RefSeq; NP_573221.2; NM_132993.3. DR RefSeq; NP_728082.2; NM_167569.2. DR UniGene; Dm.11951; -. DR IntAct; Q8MQX9; 1. DR STRING; 7227.FBpp0290627; -. DR EnsemblMetazoa; FBtr0301413; FBpp0290627; FBgn0028343. DR EnsemblMetazoa; FBtr0301414; FBpp0290628; FBgn0028343. DR GeneID; 32732; -. DR UCSC; CG8465-RA; d. melanogaster. DR CTD; 23141; -. DR FlyBase; FBgn0028343; Ankle2. DR eggNOG; ENOG410IE4A; Eukaryota. DR eggNOG; ENOG410XRMS; LUCA. DR GeneTree; ENSGT00390000016767; -. DR OMA; LCSAAWE; -. DR OrthoDB; EOG091G05GX; -. DR Reactome; R-DME-2995383; Initiation of Nuclear Envelope Reformation. DR GenomeRNAi; 32732; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0028343; Expressed in 33 organ(s), highest expression level in egg cell. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0012505; C:endomembrane system; HDA:FlyBase. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:FlyBase. DR GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central. DR GO; GO:0000902; P:cell morphogenesis; IMP:FlyBase. DR GO; GO:0007084; P:mitotic nuclear envelope reassembly; IBA:GO_Central. DR GO; GO:0042326; P:negative regulation of phosphorylation; IBA:GO_Central. DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; IBA:GO_Central. DR CDD; cd00204; ANK; 1. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR035007; ANKLE2. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR PANTHER; PTHR12349:SF4; PTHR12349:SF4; 1. DR SMART; SM00248; ANK; 2. DR SUPFAM; SSF48403; SSF48403; 2. DR PROSITE; PS50297; ANK_REP_REGION; 1. DR PROSITE; PS50088; ANK_REPEAT; 1. PE 1: Evidence at protein level; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q8MQX9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 338 375 ANK_REP_REGION. {ECO:0000259|PROSITE: FT PS50297}. FT REPEAT 338 370 ANK. {ECO:0000256|PROSITE-ProRule: FT PRU00023}. SQ SEQUENCE 1174 AA; 129082 MW; DF2A7F18FF7BD44C CRC64; MSTYFGVYIP TSKAGCFEGS VSQCIGSIAA VNIKPSNPAS GSASVASGSP SGSAASVQTG NADDGSAATK YEDPDYPPDS PLWLIFTEKS KALDILRHYK EARLREFPNL EQAESYVQFG FESIEALKRF CKAKPESKPI PIISGSGYKS SPTSTDNSCS SSPTGNGSGF IIPLGSNSSM SNLLLSDSPT SSPSSSSNVI ANGRQQQMQQ QQQQQPQQPD VSGEGPPFRA PTKQELVEFR KQIEGGHIDR VKRIIWENPR FLISSGDTPT SLKEGCRYNA MHICAQVNKA RIAQLLLKTI SDREFTQLYV GKKGSGKMCA ALNISLLDYY LNMPDKGRGE TPLHFAAKNG HVAMVEVLVS YPECKSLRNH EGKEPKEIIC LRNANATHVT IKKLELLLYD PHFVPVLRSQ SNTLPPKVGQ PFSPKDPPNL QHKADDYEGL SVDLAISALA GPMSREKAMN FYRRWKTPPR VSNNVMSPLA GSPFSSPVKV TPSKSIFDRS AGNSSPVHSG RRVLFSPLAE ATSSPKPTKN VPNGTNECEH NNNNVKPVYP LEFPATPIRK MKPDLFMAYR NNNSFDSPSL ADDSQILDMS LSRSLNASLN DSFRERHIKN TDIEKGLEVV GRQLARQEQL EWREYWDFLD SFLDIGTTEG LARLEAYFLE KTEQQADKSE TVWNFAHLHQ YFDSMAGEQQ QQLRKDKNEA AGATSPSAGV MTPYTCVEKS LQVFAKRITK TLINKIGNMV SINDTLLCEL KRLKSLIVSF KDDARFISVD FSKVHSRIAH LVASYVTHSQ EVSVAMRLQL LQMLRSLRQL LADERGREQH LGCVCASLLL MLEQAPTSAV HLPDTLKTEE LCCAAWETEQ CCACLWDANL SRKTSRRKRT KSLRAAAVVQ SQGQLQDTSG STGSSALHAS LGVGSTSLGA SRVVASASKD AWRRQQSDDE DYDSDEQVIF FDCTNVTLPY GSSSEDEENF RTPPQSLSPG ISMDLEPRYE LFIFGNEPTK RDLDVLNALS NVDIDKETLP HVYAWKTAME SYSCAEMNLF PSPRNVKVQK PEPWYSGTSS SHNSQPLLHP KRLLATPKLN AVVSGRRGSG PLTAPVTPRL ARTPSAASIQ VASETNGESV GTAVTPASPI LSFAALTAAT QSFQTPLNKV RGLFSQYRDQ RSYNEGDTPL GNRN //