ID Q8MLW7_DROME Unreviewed; 498 AA. AC Q8MLW7; DT 01-OCT-2002, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 4. DT 13-FEB-2019, entry version 149. DE SubName: Full=X box binding protein-1, isoform E {ECO:0000313|EMBL:AAM70855.4}; GN Name=Xbp1 {ECO:0000313|EMBL:AAM70855.4, GN ECO:0000313|FlyBase:FBgn0021872}; GN Synonyms=138 {ECO:0000313|EMBL:AAM70855.4}, 3 GN {ECO:0000313|EMBL:AAM70855.4}, anon-EST:Liang-1.41 GN {ECO:0000313|EMBL:AAM70855.4}, CG 9415 {ECO:0000313|EMBL:AAM70855.4}, GN clone 1.41 {ECO:0000313|EMBL:AAM70855.4}, DM18 GN {ECO:0000313|EMBL:AAM70855.4}, Dmel\CG9415 GN {ECO:0000313|EMBL:AAM70855.4}, dmXBP1 {ECO:0000313|EMBL:AAM70855.4}, GN Dxbp-1 {ECO:0000313|EMBL:AAM70855.4}, dXbp-1 GN {ECO:0000313|EMBL:AAM70855.4}, l(2)k13803 GN {ECO:0000313|EMBL:AAM70855.4}, XBP-1 {ECO:0000313|EMBL:AAM70855.4}, GN Xbp-1 {ECO:0000313|EMBL:AAM70855.4}, xbp-1 GN {ECO:0000313|EMBL:AAM70855.4}, XBP1 {ECO:0000313|EMBL:AAM70855.4}, GN xbp1 {ECO:0000313|EMBL:AAM70855.4}, XbpI GN {ECO:0000313|EMBL:AAM70855.4}; GN ORFNames=CG9415 {ECO:0000313|EMBL:AAM70855.4, GN ECO:0000313|FlyBase:FBgn0021872}, Dmel_CG9415 GN {ECO:0000313|EMBL:AAM70855.4}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AAM70855.4, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AAM70855.4; -; Genomic_DNA. DR RefSeq; NP_726032.4; NM_166427.4. DR UniGene; Dm.1850; -. DR ProteinModelPortal; Q8MLW7; -. DR IntAct; Q8MLW7; 2. DR STRING; 7227.FBpp0301746; -. DR PaxDb; Q8MLW7; -. DR PRIDE; Q8MLW7; -. DR EnsemblMetazoa; FBtr0310045; FBpp0301746; FBgn0021872. DR GeneID; 44226; -. DR CTD; 7494; -. DR FlyBase; FBgn0021872; Xbp1. DR eggNOG; KOG4005; Eukaryota. DR eggNOG; ENOG410XSJI; LUCA. DR InParanoid; Q8MLW7; -. DR OMA; GAEGWYT; -. DR ChiTaRS; Xbp1; fly. DR GenomeRNAi; 44226; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0021872; Expressed in 57 organ(s), highest expression level in spermathecum. DR ExpressionAtlas; Q8MLW7; differential. DR Genevisible; Q8MLW7; DM. DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; ISS:FlyBase. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISS:FlyBase. DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:FlyBase. DR GO; GO:0036335; P:intestinal stem cell homeostasis; IMP:FlyBase. DR GO; GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IBA:GO_Central. DR GO; GO:0006990; P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; IDA:FlyBase. DR GO; GO:0036490; P:regulation of translation in response to endoplasmic reticulum stress; IMP:FlyBase. DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IDA:FlyBase. DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central. DR InterPro; IPR004827; bZIP. DR Pfam; PF07716; bZIP_2; 1. DR SMART; SM00338; BRLZ; 1. DR PROSITE; PS50217; BZIP; 1. DR PROSITE; PS00036; BZIP_BASIC; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 81 144 BZIP. {ECO:0000259|PROSITE:PS50217}. FT COILED 99 161 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 498 AA; 53106 MW; 3C8C92896C93CAD8 CRC64; MAPTANTVLI TVPRTAITSN NLPKLRPAPL TAALLKVSAT PSASPTPSSS GYASSSNMDD DNMAASQPKA KKRRLDHLTW EEKVQRKKLK NRVAAQTSRD RKKARMEEMD YEIKELTDRT EILQNKCDSL QAINESLLAK NHKLDSELEL LRQELAELKQ QQQHNTRCIS QSNASAGAEG CASTNLGSAA GYTTGGHTVV SASAGGAAEE QQEPGLTLES CGPLPTLQDM LGVDEEFDVK RLEELAESLL ADITADLETG AGASSPAAAQ DAGNAERLPG PMVGPAAERL ESDGHRANGL NVEQEQETEH KVSLNVQMLK INGNPQHTTA APASRTATIT ATAAASQLQA TPDTVYGTYD AKTNSITIVM DGDAVPVNEA VEEIYCDGVS AGDDSTDVIM KCPPPATSPS QVYLNVMNAV DNSDDEESFD PIDRFLRPRV KAISPLAKSP ALSLHSATSD HGYESILGSP TSVALTLPAD EDDFPWESNF DELFPSLI //