ID CXB2_MACMU STANDARD; PRT; 226 AA. AC Q8MIT8; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Gap junction beta-2 protein (Connexin 26) (Cx26). GN Name=GJB2; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Cercopithecidae; OC Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP NUCLEOTIDE SEQUENCE. RA Orten D.J., Bizzarri-Kriener C., Askew J.W., Li J.-L., Louis E., RA Kelley P.M., Kimberling W.J.; RT "Sequence comparison of primate connexin 26 (GJB2) genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: One gap junction consists of a cluster of closely packed CC pairs of transmembrane channels, the connexons, through which CC materials of low MW diffuse from one cell to a neighboring cell CC (By similarity). CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins (By CC similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I) CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY046584; AAL03976.1; -. DR InterPro; IPR000500; Connexin. DR InterPro; IPR002268; Connexin26. DR Pfam; PF00029; Connexin; 1. DR PRINTS; PR00206; CONNEXIN. DR SMART; SM00037; CNX; 1. DR PROSITE; PS00407; CONNEXINS_1; 1. DR PROSITE; PS00408; CONNEXINS_2; 1. KW Gap junction; Transmembrane. FT DOMAIN 1 20 Cytoplasmic (Potential). FT TRANSMEM 21 40 Potential. FT DOMAIN 41 75 Extracellular (Potential). FT TRANSMEM 76 98 Potential. FT DOMAIN 99 131 Cytoplasmic (Potential). FT TRANSMEM 132 154 Potential. FT DOMAIN 155 192 Extracellular (Potential). FT TRANSMEM 193 215 Potential. FT DOMAIN 216 226 Cytoplasmic (Potential). SQ SEQUENCE 226 AA; 26224 MW; 1F4BAC3BB20D0528 CRC64; MDWGALQTIL GGVNKYSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRKFIKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTSSI FFRVVFEAAF MYVFYVMYDG FSMQRLVKCN AWPCPNTVDC FVSRPTEKTV FTVFMIAVSG ICILLNVTEL CYLLIRYCSG KSKKPV //