ID CXB2_MACMU Reviewed; 226 AA. AC Q8MIT8; DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 31-OCT-2006, entry version 22. DE Gap junction beta-2 protein (Connexin-26) (Cx26). GN Name=GJB2; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Orten D.J., Bizzarri-Kriener C., Askew J.W., Li J.-L., Louis E., RA Kelley P.M., Kimberling W.J.; RT "Sequence comparison of primate connexin 26 (GJB2) genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: One gap junction consists of a cluster of closely packed CC pairs of transmembrane channels, the connexons, through which CC materials of low MW diffuse from one cell to a neighboring cell CC (By similarity). CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins (By CC similarity). CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein (By CC similarity). CC -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I) CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY046584; AAL03976.1; -; Genomic_DNA. DR InterPro; IPR000500; Connexin. DR InterPro; IPR002268; Connexin26. DR InterPro; IPR013092; Connexin_N. DR PANTHER; PTHR11984; Connexin; 1. DR Pfam; PF00029; Connexin; 1. DR PRINTS; PR00206; CONNEXIN. DR PRINTS; PR01139; CONNEXINB2. DR SMART; SM00037; CNX; 1. DR PROSITE; PS00407; CONNEXINS_1; 1. DR PROSITE; PS00408; CONNEXINS_2; 1. KW Gap junction; Membrane; Transmembrane. FT CHAIN 1 226 Gap junction beta-2 protein. FT /FTId=PRO_0000057857. FT TOPO_DOM 1 20 Cytoplasmic (Potential). FT TRANSMEM 21 40 Potential. FT TOPO_DOM 41 75 Extracellular (Potential). FT TRANSMEM 76 98 Potential. FT TOPO_DOM 99 131 Cytoplasmic (Potential). FT TRANSMEM 132 154 Potential. FT TOPO_DOM 155 192 Extracellular (Potential). FT TRANSMEM 193 215 Potential. FT TOPO_DOM 216 226 Cytoplasmic (Potential). SQ SEQUENCE 226 AA; 26224 MW; 1F4BAC3BB20D0528 CRC64; MDWGALQTIL GGVNKYSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRKFIKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTSSI FFRVVFEAAF MYVFYVMYDG FSMQRLVKCN AWPCPNTVDC FVSRPTEKTV FTVFMIAVSG ICILLNVTEL CYLLIRYCSG KSKKPV //